王小慧
职称：助理研究员
邮箱：wangxiaohui@ucas.ac.cn
教育背景：
2010.9-2014.6 兰州大学生命科学学院生物学基地班本科
2014.9-2019.11 中科院遗传与发育生物学研究所生物物理学博士
2020.1-2022.3 西湖大学生物物理学博士后
科研经历：
2014.9-2019.11:博士期间，利用X-ray晶体学解析了新型阳离子通道蛋白TRIC-A
(Trimeric intracellular cation)的高分辨率结构并利用人工脂双层分析了其单通道特性，该项目成果以第一作者的身份发表在PNAS杂 志上。
Topic: Structural basis for activity of TRIC counter-ion channels in calcium release
2020.1-2021.12:博士后期间，利用单颗粒冷冻电镜技术分别解析了钾离子通道蛋白和高亲和性钾离子转运蛋白的高分辨三维结构，并利用全细胞膜片钳和酵母生长实验验证其功能特性。
所获奖项：
曾荣获国家奖学金、益海嘉里优秀学生、中国科学院地奥奖学金等
代表性论文：
(1) Xiaohui Wang; Xiaoshuai Shen; Yannan Qu; Heng Zhang; Chu Wang; Fan Yang; Huaizong Shen ; Structural insights into ion selectivity and transport mechanisms of Oryza sativa HKT2;1 and HKT2;2/1 transporters, Nature Plants, 2024, 10: 633-644
(2) Xiaohui Wang; Min Su; Feng Gao; Wenjun Xie; Yang Zeng; De lin Li; Xue lei Liu; Hong Zhao;
Li Qin; Fei Li; Qun Liu; Oliver B. Clarke; Sin Man Lam; Guanghou Shui; Wayne A. Hendrickson; Yong Chen ; Structural basis for activity of TRIC counter-ion channels in calcium release, Proceedings of the National Academy of Sciences, 2019, 116(10): 4238-4243
(3) Xiaohui Wang; Xuelei Liu; Yonglin Su; Huaizong Shen ; Rice Responses to Abiotic Stress:
Key Proteins and Molecular Mechanisms, International Journal of Molecular Sciences, 2025, 26(3): 896
(4) Su, Min; Gao, Feng; Yuan, Qi; Mao, Yang; Li, De-lin; Guo, Youzhong; Yang, Cheng; Xiaohui Wang; Bruni, Renato; Kloss, Brian; Zhao, Hong; Zeng, Yang; Zhang, Fa-ben; Marks, Andrew R.;
Hendrickson, Wayne A.; Chen, Yu-hang ; Structural basis for conductance through TRIC cationchannels, Nature Communications, 2017, 8(8): 15103
(5) Qianhua Dong; Xue-lei Liu; Xiao-hui Wang; Yu Zhao; Yu-hang Chen; Fei Li ; Ccp1-Ndc80
switch at the N terminus of CENP-T regulates kinetochore assembly, Proceedings of the National Academy of Sciences, 2021, 118(48)
