吴振芳
副研究员
邮箱：zhenfwu@ucas.ac.cn
科研与教育经历
（1）2023.11-至今，国科大杭州高等研究院生命与健康学院，副研究员
（2）2019.1-2023.9，上海交通大学，医学院附属第九人民医院，副研究员
（3）2014.7-2018.5, 中国科学院，生物化学与细胞生物学研究所，博士后
（4）2009.9-2014.6，中国科学院微生物研究所，遗传学，博士学位
（5）2006.9-2009.7，四川农业大学，生物物理学，硕士学位
（6）2002.9-2006.7, 重庆邮电大学，生物信息学院，学士学位
研究领域
1、核内小体的结构与功能研究：联合运用结构和功能生物学多种技术手段，研究核内小体调控基因组的三维结构和转录的功能及其分子机制；
2、端粒维持及其调控机制：聚焦端粒维持及其调控机制的研究，为揭示端粒维持缺陷综合征的致病机制提供重要线索，并为寻找抗衰老和肿瘤药物治疗靶点提供重要依据。
基金及荣誉
1、2023年国科大杭高院“青苗计划”（主持）
2、2023年国家自然科学基金面上项目（主持）
3、2016年国家自然科学基金青年项目（主持）
4、中国博士后科学基金第57批面上资助（主持）
5、中国博士后科学基金第九批特别资助（主持）
6、2020年赛诺菲-中国科学院上海生命科学研究院优秀博士后奖励基金
7、中国科学院大学微生物研究所所长奖学金
8、博士研究生国家奖学金
发表论文
通讯/第一作者（含共同）:
1. He Y#, Zhu W#, Wang X#, Wan F, Zha L, Wu Y, Lei M, Wu Z*(2026). Molecular insights into assembly of the yeast CST-Polα/primase complex for telomere maintenance. Commun Biol (article in press).
2. Chen J, Yang L, Zhu X, Wu J, Lei M, Wu Z*(2026). The Ess1 prolyl isomerase represses TERRA transcription and promotes telomere replication in Saccharomyces cerevisiae. Genetics 232(3): iyag017.
3. Gao X*, Wu Z* (2025). IRES-Mediated Translation: Expanding the toolkits of RNA therapy. Int J Mol Sci, 26: 10542.
4. Wu Z*, Gu X, Zha L, Yang Q, Zhou Y*, Zeng Z* (2024). Structural and functional insights into yeast Tbf1 as an atypical telomeric repeat-binding factor. Structure, 32(7): 889-898.e3.
5. Sun H#, Wu Z#*, Zhou Y#, Lu Y, Lu H, Chen H, Shi S, Zeng Z*, Wu J*, Lei M* (2022) Structural insights into Pot1-ssDNA, Pot1-Tpz1 and Tpz1-Ccq1 Interactions within fission yeast shelterin complex. PLoS Genet 18: e1010308.
6. Wan F#, Ding Y#, Zhang Y#, Wu Z#, Li S, Yang L, Yan X, Lan P, Li G*, Wu J*, Lei M* (2021). Zipper head mechanism of telomere synthesis by human telomerase. Cell Res 31, 1275-1290.
7. Shi S#, Zhou Y#, Lu Y, Sun H, Xue J, Wu Z*, Lei M* (2021). Ccq1–Raf2 interaction mediates CLRC recruitment to establish heterochromatin at telomeres. Life Sci Alliance 4(11): e202101106.
8. Chen C#, Tan M#, Wu Z#, Zhang Y, He F, Lu Y, Li S, Cao M, Li G*, Wu J*, Cheng H*, Lei M* (2021). Structural and functional insights into R-loop prevention and mRNA export by budding yeast THO-Sub2 complex. Sci Bull 66(23): 2347-2352.
9. Ge Y#, Wu Z#*, Chen H, Zhong Q, Li G, Wu J*, Lei M* (2020). Structural insights into telomere protection and homeostasis regulation by yeast CST complex, Nat Struct Mol Biol 27(8): 752-762.
10. Wu Z*, He MH, Zhang LL, Liu J, Zhang QD, Zhou JQ* (2018). Rad6-Bre1 mediated histone H2Bub1 protects uncapped telomeres from exonuclease Exo1 in Saccharomyces cerevisiae. DNA Repair (Amst) 72: 64~76.
11. Zhang LL, Wu Z*, Zhou JQ* (2018). Tel1 and Rif2 oppositely regulate telomere protection at uncapped telomeres in Saccharomyces cerevisiae. J Genet Genomics 45(9): 467~476.
12. Wu Z, Liu J, Zhang QD, Lv DK, Wu NF, Zhou JQ* (2017) Rad6-Bre1-mediated H2B ubiquitination regulates telomere replication by promoting telomere-end resection. Nucleic Acids Res 45: 3308-3322.
13. Wu Z, Yang H, Liu J, Wang L, Xiang H* (2014) Association between dynamics of multiple replication origins and evolution of multireplicon genome architecture in haloarchaea. Genome Biol Evol 6: 2799-2810.
14. Wu Z, Liu J, Yang H, Liu H, Xiang H* (2014) Multiple replication origins with diverse controlling mechanisms in Haloarcula hispanica. Nucleic Acids Res 42, 2282-2294.
15. Wu Z, Liu J, Yang H, Xiang H* (2014) DNA replication origins in archaea. Front Microbiol 5: 179.
16. Wu Z, Liu H, Liu J, Liu X, Xiang H* (2012) Diversity and evolution of multiple orc/cdc6-adjacent replication origins in haloarchaea. BMC Genomics 13: 478.
参与作者：
17. Shao Y, Lu N, Wu Z, Cai C, Wang S, Zhang LL, Zhou F, Xiao S, Liu L, Zeng X, Zheng H, Yang C, Zhao Z, Zhao G*, Zhou JQ*, Xue X*, Qin Z* (2018). Creating a functional single-chromosome yeast. Nature 560(7718): 331-335.
18. Yang H, Wu Z, Liu J, Liu X, Wang L, Cai S, Xiang H* (2015) Activation of a dormant replication origin is essential for Haloferax mediterranei lacking the primary origins. Nat Commun 6:8321.
19. Wang Q#, Li S#, Wan F#, Xu Y#, Wu Z, Cao M, Lan P*, Lei M*, Wu J* (2021). Structural insights into transcriptional regulation of human RNA polymerase III. Nat Struct Mol Biol 28 (2): 220-227.
20. Zhang C#, Shuai J#, Ran Z#, Zhao J, Wu Z, Liao R, Wu J*, Ma W*, and Lei M* (2020). Structural insights into NDH-1 mediated cyclic electron transfer. Nat Commun 11(1): 888.
21. He MH, Liu JC, Lu YS, Wu ZJ, Liu YY, Wu Z, Peng J, Zhou JQ* (2019). KEOPS complex promotes homologous recombination via DNA resection. Nucleic Acids Res 47(11):5684-5697.
22. Liu J, He MH, Peng J, Duan YM, Lu YS, Wu Z, Gong T, Li HT, Zhou JQ* (2016). Tethering telomerase to telomeres increases genome instability and promotes chronological aging in yeast. Aging (Albany NY) 8(11):2827-2847.
23. Liu H, Luo Y, Han J, Wu J, Wu Z, Feng D, Cai S, Li M, Liu J, Zhou J, Xiang H* (2013). Proteome reference map of Haloarcula hispanica and comparative proteomic and transcriptomic analysis of polyhydroxyalkanoate biosynthesis under genetic and environmental perturbations. J Proteome Res 12(3):1300-15.
24. Liu X, Miao D, Zhang F, Wu Z, Liu J, Xiang H* (2013). Characterization of the minimal replicon of pHM300 and independent copy number control of major and minor chromosomes of Haloferax mediterranei. FEMS Microbiol Lett 339(1):66-74.
25. Liu J, Li J, Wu Z, Pei H, Zhou J, Xiang H* (2012). Identification and characterization of the cognate anti-sigma factor and specific promoter elements of a T. tengcongensis ECF sigma factor. PLoS One 7(7): e40885.
26. Liao Y, Zeng M, Wu Z, Chen H, Wang HN, Wu Q, Shan Z, Han XY. Improving phytase enzyme activity in a recombinant phyA mutant phytase from Aspergillus niger N25 by error-prone PCR. Appl Biochem Biotechnol 166(3): 549-62.
27. Liu H, Wu Z, Li M, Zhang F, Zheng H, Han J, Liu J, Zhou J, Wang S, Xiang H. Complete genome sequence of Haloarcula hispanica, a model Haloarchaeon for studying genetics, metabolism, and virus-host interaction. J Bacteriol 193(21): 6086-7.
28. Wu Z, Tang Z, Chen H, Han X, Lai X, Wu Q. Construction of a Pichia pastoris recombinant strain capable of over-expressing phytase and endoglucanase. Chin J Biotech 26(5): 616–622.
29. 吴振芳，陈惠，曾民，吴琦. 内切葡聚糖酶基因在毕赤酵母中高效表达研究 (2009). 农业生物技术学报17(3):529-535.
30. 吴振芳，陈惠，曾民，吴琦. 蛋白质新功能定向进化研究策略 (2009). 生物技术通报3: 5.
