副研究员
地址：国科大杭州高等研究院1号楼1A-126
邮箱：huangyp@ucas.ac.cn
2005年本科毕业于福建师范大学生物工程专业，2009年硕士毕业于福建师范大学生化与分子生物学专业，2015年博士毕业于清华大学生物学专业。2015年至2019年在清华大学从事博士后研究工作，2020年进入杭高院参加工作。主页：
https://people.ucas.ac.cn/~huangypHIAS
主要研究方向：
1.退行性、代谢性疾病分子机制研究
2.线粒体稳态调控分子机理研究
3.辅酶A（CoA）代谢通路分子调控机制
利用模式生物黑腹果蝇以及哺乳动物细胞等模型研究退行性、代谢性疾病(Cell reports, 2014;JAD, 2015;Commun Biol., 2019;NRR, 2022）及线粒体稳态调控的分子机理（Nat Commun., 2022），目前正致力于利用遗传筛选、分子细胞生物学及多组学方法挖掘线粒体稳态调控、退行性及代谢疾病通路的新调控机制。主持了国自然青年基金及博士后基金面上资助各1项，参与了科技部重点研发计划、中科院科技服务网络计划项目、国自然重大项目等项目。
代表性论文：
2024
◆CY Zhang, JL Wang, TZ Yao, JX Hu, FF Sun, CL Feng, ZD Sun, YZ Shao, Z Wang, JR Wu, YP Huang*. Proteomic analysis across aged tissues reveals distinct signatures and the crucial involvement of midgut barrier function in the regulation of aging. Aging Cell. 2024 Sep 25:e14344. doi: 10.1111/acel.14344. (*: 通讯)
◆ Mou W, Tang Y, Huang Y, Wu Z, Cui Y. Upregulation of neuronal ER-phagy improves organismal fitness and alleviates APP toxicity. Cell Rep. 2024 May 28;43(5):114255.
2023
◆Hu, J.; Sha, W.; Yuan, S.; Wu, J.*; Huang, Y*. Aggregation, Transmission, and Toxicity of the Microtubule-Associated Protein Tau: A Complex Comprehension. Int. J. Mol. Sci. 2023, 24, 15023. https://doi.org/10.3390/ijms241915023 (*: 通讯)
◆Sun, Z.; Shao, Y.; Yan, K.; Yao, T.; Liu, L.; Sun, F.; Wu, J.; Huang, Y*. The Link between Trace Metal Elements and Glucose Metabolism: Evidence from Zinc, Copper, Iron, and Manganese-Mediated Metabolic Regulation. Metabolites 2023, 13, 1048. https://doi.org/10.3390/metabo13101048 (*: 通讯)
2022
◆Zhendong Sun, Jiaxin Hu, Jiarui Wu*, Bing Zhou*,Yunpeng Huang*. Toxicities of amyloid-beta and tau protein are reciprocally enhanced in theDrosophilamodel.Neural Regen Res.2022 Oct;17(10):2286-2292. (*:通讯作者)
◆Yinglu Tang#, Yunpeng Huang#, Zhihui Wan, Bing Zhou, Zhihao Wu. Mitochondrial Quality Control Links Two Seemingly Unrelated Neurodegenerative Diseases. Autophagy. 2022 DOI: 10.1080/15548627.2022.2094605 (#: 共同一作)
◆Yunpeng Huang#, Zhihui Wan#, Yinglu Tang#, Junxuan Xu, Bretton Laboret, Sree Nallamothu, Chenyu Yang, Boxiang Liu, Rongze Olivia Lu, Bingwei Lu, Juan Feng, Jing Cao, Susan Hayflick, Zhihao Wu, Bing Zhou. Pantothenate kinase 2 interacts with PINK1 to regulate mitochondrial quality control via acetyl-CoA metabolism.Nat Commun.2022 May 3;13(1):2412. (#:共同一作)
2014-2021
◆Yunpeng Huang, Zhihui Wan, Zhiqing Wang, Bing Zhou. Insulin signaling inDrosophila melanogastermediates Aβ toxicity. Commun Biol.2019 Jan 8;2:13.
◆Yunpeng Huang, Zhihao Wu, Bing Zhou. Behind the curtain of tauopathy: a show of multiple players orchestrating tau toxicity. Cell Mol Life Sci. 2016 Jan;73(1):1-21.
◆Yunpeng Huang, Zhihao Wu, Bing Zhou. hSOD1 promotes tau phosphorylation and toxicity in the Drosophila model. J Alzheimers Dis.2015; 45(1):235-44.
◆Yunpeng Huang#, Zhihao Wu#, Yu Cao, Minglin Lang, Bingwei Lu, Bing Zhou. Zinc binding directly regulates tau toxicity independent of tau hyperphosphorylation. Cell Reports.2014 Aug 7;8(3):831-42. (#:共同一作)
◆Na Gao,Yunpeng Huang, Tingting Chu, Qianqian Li, Bing Zhou, Yongxiang Chen, Yufen Zhao, Yanmei Li. TDP-43 specific reduction induced by Di-hydrophobic tags conjugated peptides. Bioorg Chem.2019 Mar;84:254-259.
