副研究员
地址：国科大杭州高等研究院1号楼1A-126
邮箱：huangyp@ucas.ac.cn
教育与科研经历：
2005年本科毕业于福建师范大学生物工程专业，2009年硕士毕业于福建师范大学生化与分子生物学专业，2015年博士毕业于清华大学生物学专业。2015年至2019年在清华大学从事博士后研究工作，2020年进入杭高院参加工作。主页：https://people.ucas.ac.cn/~huangypHIAS
主要研究方向：
1.退行性、代谢性疾病分子机制研究
2.线粒体稳态调控分子机理研究
3.辅酶A（CoA）代谢通路分子调控机制
利用模式生物黑腹果蝇以及哺乳动物细胞等模型研究退行性、代谢性疾病(Cell reports, 2014;JAD, 2015;Commun Biol., 2019;NRR, 2022）及线粒体稳态调控的分子机理（Nat Commun., 2022），目前正致力于利用遗传筛选、分子细胞生物学及多组学方法挖掘线粒体稳态调控、退行性及代谢疾病通路的新调控机制。主持了国自然青年基金及博士后基金面上资助各1项，参与了科技部重点研发计划、中科院科技服务网络计划项目、国自然重大项目等项目。
代表性论文：
https://people.ucas.ac.cn/~huangypHIAS#%20799329
2025
◆Y Shao, J Hu, K Yan, K Zheng, W Sha, J Wang, J Wu, Y Huang*. Impaired mitochondrial integrity and compromised energy production underscore the mechanism underlying CoASY protein-associated neurodegeneration. Cell Mol Life Sci. 2025, Accepted (*: 通讯作者)
◆Chen Y, Hu J, Zhao P, Fang J, Kuang Y, Liu Z, Dong S, Yao W, Ding Y, Wang X, Pan Y, Wu J, Zhao J, Yang J, Xu Z, Liu X, Zhang Y, Wu C, Zhang L, Fan M, Feng S, Hong Z, Yan Z, Xia H, Tang K, Yang B, Liu W, Sun Q, Mei K*, Zou W*, Huang Y*, Feng D*, Yi C*. Rpl12 is a conserved ribophagy receptor. Nat Cell Biol. 2025 Feb 11. doi: 10.1038/s41556-024-01598-2. (*: 共同通讯)
2024
◆ CY Zhang, JL Wang, TZ Yao, JX Hu, FF Sun, CL Feng, ZD Sun, YZ Shao, Z Wang, JR Wu, YP Huang*. Proteomic analysis across aged tissues reveals distinct signatures and the crucial involvement of midgut barrier function in the regulation of aging. Aging Cell. 2024 Sep 25:e14344. doi: 10.1111/acel.14344. (*: 通讯作者)
◆ Mou W, Tang Y, Huang Y, Wu Z, Cui Y. Upregulation of neuronal ER-phagy improves organismal fitness and alleviates APP toxicity. Cell Rep. 2024 May 28;43(5):114255.
2023
◆ Hu, J.; Sha, W.; Yuan, S.; Wu, J.*; Huang, Y*. Aggregation, Transmission, and Toxicity of the Microtubule-Associated Protein Tau: A Complex Comprehension. Int. J. Mol. Sci. 2023, 24, 15023. https://doi.org/10.3390/ijms241915023 (*: 通讯作者)
◆ Sun, Z.; Shao, Y.; Yan, K.; Yao, T.; Liu, L.; Sun, F.; Wu, J.; Huang, Y*. The Link between Trace Metal Elements and Glucose Metabolism: Evidence from Zinc, Copper, Iron, and Manganese-Mediated Metabolic Regulation. Metabolites 2023, 13, 1048. https://doi.org/10.3390/metabo13101048 (*: 通讯作者)
2022
◆ Huang Y#, Wan Z#, Tang Y#, Xu J, Laboret B, Nallamothu S, Yang C, Liu B, Lu RO, Lu B, Feng J, Cao J, Hayflick S, Wu Z, Zhou B. Pantothenate kinase 2 interacts with PINK1 to regulate mitochondrial quality control via acetyl-CoA metabolism. Nat Commun. 2022 May 3;13(1):2412. doi: 10.1038/s41467-022-30178-x. （#：共同作者）
◆ Yinglu Tang#, Yunpeng Huang#, Zhihui Wan, Bing Zhou, Zhihao Wu. Mitochondrial Quality Control Links Two Seemingly Unrelated Neurodegenerative Diseases. Autophagy. 2022 DOI: 10.1080/15548627.2022.2094605 (#: 共同一作)
◆ Sun ZD, Hu JX, Wu JR*, Zhou B*, Huang YP*. Toxicities of amyloid-beta and tau protein are reciprocally enhanced in the Drosophila model. Neural Regen Res. 2022 Oct;17(10):2286-2292. doi: 10.4103/1673-5374.336872. (*: 通讯作者)
2014-2019
1）. Huang Y, Wan Z, Wang Z, Zhou B. Insulin signaling in Drosophila melanogaster mediates Aβ toxicity. Commun Biol. 2019 Jan 8;2:13. doi: 10.1038/s42003-018-0253-x.
2）. Gao N, Huang YP, Chu TT, Li QQ, Zhou B, Chen YX, Zhao YF, Li YM. TDP-43 specific reduction induced by Di-hydrophobic tags conjugated peptides. Bioorg Chem. 2019 Mar;84:254-259. doi: 10.1016/j.bioorg.2018.11.042. Epub 2018 Nov 27.
3）. Qiang W, Huang Y, Wan Z, Zhou B. Metal-metal interaction mediates the iron induction of Drosophila MtnB. Biochem Biophys Res Commun. 2017 Jun 3;487(3):646-652. doi: 10.1016/j.bbrc.2017.04.109. Epub 2017 Apr 21.
4）. Huang Y, Wu Z, Zhou B. Behind the curtain of tauopathy: a show of multiple players orchestrating tau toxicity. Cell Mol Life Sci. 2016 Jan;73(1):1-21. doi: 10.1007/s00018-015-2042-8. Epub 2015 Sep 24.
5）. Huang Y, Wu Z, Zhou B. hSOD1 promotes tau phosphorylation and toxicity in the Drosophila model. J Alzheimers Dis. 2015;45(1):235-44. doi: 10.3233/JAD-141608.
6）. Huang Y#, Wu Z#, Cao Y, Lang M, Lu B, Zhou B. Zinc binding directly regulates tau toxicity independent of tau hyperphosphorylation. Cell Rep. 2014 Aug 7;8(3):831-42. doi: 10.1016/j.celrep.2014.06.047. Epub 2014 Jul 24. （#：共同作者）
