唐标
特聘副研究员
邮箱：tangbiao@ucas.ac.cn
教育背景
2011.9-2016.6，复旦大学，生命科学学院，微生物学，博士
2005.9-2009.6，南京农业大学，生命科学学院，国家生物学理科基地，本科
工作经历
2023.9---------，国科大杭州高等研究院，特聘副研究员
2016.7-2023.8，浙江省农业科学院，助理研究员、特聘副研究员
2017.5-2017.8，美国田纳西大学，访问学者
2009.7-2011.8，上海人类基因组南方研究中心，技术员
研究方向
从事细菌耐药性与基因组学研究。
科研项目
2018.01-2020.12，国家自然科学基金委员会，青年项目（31700007）
2023.01-2025.12，浙江省自然科学基金委员会，基础公益项目（LY23C180001
2018.01-2019.12，浙江省自然科学基金委员会，基础公益项目（2017C32021）
2023.01-2025.12，浙江省科学技术厅，“领雁”研发攻关计划 (2023C03045)，主持子课题
2020.01-2022.12，浙江省科学技术厅，省重点研发计划（2020C02031），主持子课题
2021.01-2023.12，浙江省农业农村厅，农业重大技术协同推广计划（2021XTTGXM03），主持子课题
2023.01-2024.12，浙江省农业农村厅，浙江省“三农九方”科技协作计划（2023SNJF058），主持子课题
2022.01-2023.12，杭州市科学技术局，杭州市农业和社会发展领域重点项目（202203A08），主持子课题
发表论文 (第一或通讯作者，含共同)
1. Li J#, Long X#, Lin H, Song C, Zhao GP, Tang B*. Co-existence of tmexCD2-toprJ2 and blaNDM-1 on a single plasmid carried by Raoultella ornithinolytica isolated from public garbage bins. Journal of Global Antimicrobial Resistance. 2024, 37:1-3.
2. Tang B#, Zhao H#, Li J, Liu N, Huang Y, Wang J, Yue M*. Detection of clinical Serratia marcescens isolates carrying blaKPC-2 in a hospital in China. Heliyon. 2024, 10(8):e29702.
3. Ni J#, Guan C#, Huang Y, Yang H, Pan D*, Tang B*. Emergence of plasmid harboring multidrug resistance gene cfr in porcine Salmonella. International Journal of Antimicrobial Agents. 2023, 61(3):106833.
首次在沙门菌中发现携带多重耐药基因cfr的质粒
4. Tang B#, Guan C#, Lin H, Liu C, Yang H, Zhao GP, Yue M*. The emergence of co-existence of mcr-1 and blaNDM-5 in Escherichia fergusonii. International Journal of Antimicrobial Agents. 2023, 61(3):106742.
首次发现同时携带黏菌素耐药基因mcr-1和碳青霉烯类耐药基因blaNDM-5的弗格森埃希菌
5. Tang B#, Zou C#, Stefan Schwarz, Xu C, Hao W, Yan X, Huang Y, Ni J, Yang H, Du X*, Shan X*. Linezolid-resistant Enterococcus faecalis of chicken origin harbored chromosome-borne optrA and plasmid-borne cfr, cfr(D) and poxtA2 genes. Microbiology Spectrum. 2023, 11(3): e0274122.
6. Tang B#, Siddique A#, Jia C, Ed-Dra A, Wu J, Lin H, Yue M*, Genome-based risk assessment for foodborne Salmonella enterica from food animals in China: A One Health perspective. International Journal of Food Microbiology. 2023, 390:110120.
“One Health”视角下基于基因组进行中国食品动物源沙门菌风险评估
7. Ma J#, Wang J#, Yang H, Su M, Li R, Bai L, Feng J, Huang Y, Yang Z*, Tang B*. IncHI1 plasmids mediated the tet(X4) gene spread in Enterobacteriaceae in porcine. Frontiers in Microbiology. 2023, 14:1128905.
8. Ni J#, Long X#, Wang M, Ma J, Sun Y, Wang W, Yue M, Yang H, Pan D*, Tang B*. Transmission of linezolid-resistant Enterococcus isolates carrying optrA and poxtA genes in slaughterhouses. Frontiers in Sustainable Food Systems. 2023, 7:1179078.
9. Wang C#, Tang B#, Wu J, Jin X, Ke S, Yang H*, Liu Y*. Detection of mcr-1-harbouring Escherichia coli by quantum dot labelling of synthetic small peptides mimicking lipopolysaccharide receptors. International Journal of Antimicrobial Agents. 2023, 62(3):106898.
10. Wang J#, Huang Y#, Guan C, Li J, Yang H, Zhao GP, Liu C, Ma J*, Tang B*. Characterization of an Escherichia coli isolate coharboring the virulence gene astA and tigecycline resistance gene tet(X4) from a dead piglet. Pathogens. 2023, 12(7):903.
11. Tang B#, Zheng X#, Lin J, Wu J, Lin R, Jiang H, Ji X, Yang H, Shen Z*, Xia F*. Prevalence of the phenicol resistance gene fexA in Campylobacter isolated from the poultry supply chain. International Journal of Food Microbiology. 2022, 381:109912.
阐明禽产业链上弯曲菌中氟苯尼考耐药基因fexA的流行
12. Tang B#, Elbediwi M#, Nambiar B R, Yang H, Lin J, Yue M*. Genomic characterization of Antimicrobial-resistant Salmonella enterica in duck, chicken and pig farms and retail markets in Eastern China. Microbiology Spectrum. 2022, 10(5):e01257-22.
解析中国华东地区食品动物源沙门菌的基因组特征和耐药基因分布
13. Ma J, Zhou W, Wu J, Liu X, Lin J, Ji X, Lin H, Wang J, Jiang H, Zhou Q, Zhao GP, Yang H*, Tang B*. Large-Scale studies on antimicrobial resistance and molecular characterization of Escherichia coli from food animals in developed areas of Eastern China. Microbiology Spectrum. 2022, 11:e0201522.
通过大尺度分离浙江省11个地市的1,468株大肠杆菌进行药敏实验和基因组分析，摸底了浙江省畜禽源细菌耐药性的水平
14. Tang B#, Chang J#, Chen Y#, Lin J, Xiao X, Xia X, Lin J, Yang H*, Zhao GP*. Escherichia fergusonii, an underrated repository for antimicrobial resistance in food animals. Microbiology Spectrum. 2022, 10(1):e0161721.
发现了潜在的风险耐药基因宿主：弗格森埃希菌
15. Tang B#, Wang C, Sun D, Lin H, Ma J, Guo H*, Yang H*, Li X*. In Silico characterization of blaNDM-harboring conjugative plasmids in Acinetobacter species. Microbiology Spectrum. 2022, 10(6):e0210222.
16. Ma J#, Tang B#, Lin J#, Ed-Dra A, Lin H, Wu J, Dong Y, Yang H, Yue M. Genome assessment of Carbapenem- and Colistin-Resistant Escherichia coli from patients in a sentinel hospital in China. Cells. 2022, 11(21):3480.
17. Tang B#, Ni J#, Lin J, Sun Y, Lin H, Wu Y, Yang H*, Yue M*. Genomic characterization of multidrug-resistance gene cfr in Escherichia coli recovered from food animals in Eastern China. Frontiers in Microbiology. 2022, 13:999778.
18. Tang B#, Wang J#, Zheng X, Chang J, Ma J, Wang J, Ji X, Yang H, Ding B*. Antimicrobial resistance surveillance of Escherichia coli from chickens in the Qinghai Plateau of China. Frontiers in Microbiology. 2022, 13:885132.
19. Li X, Zhu L, Wang X, Li J*, Tang B*. Evaluation of IR Biotyper for Lactiplantibacillus plantarum typing and its application potential in probiotic preliminary screening. Frontiers in Microbiology. 2022, 13:823120.
20. Guan C, Tang B*, Yang H, Ma J, Huang Y, Liu C*. Emergence of plasmid-mediated tigecycline resistance gene, tet(X4), in Escherichia fergusonii from pigs. Journal of Global Antimicrobial Resistance. 2022, 30:249-251.
发现猪源弗格森埃希菌携带替加环素耐药基因tet(X4)
21. Wang J, Tang B*, Lin R, Zheng X, Ma J, Xiong X, Jiang H, Yang H, Ding B*. Emergence of mcr-1- and blaNDM-5-harbouring IncHI2 plasmids in Escherichia coli strains isolated from meat in Zhejiang, China. Journal of Global Antimicrobial Resistance. 2022, 30:103-106.
22. Zheng X, Ma J, Lu Y, Sun D, Yang H, Xia F*, Tang B*. Detection of tet(X6) variant-producing Proteus terrae subsp. cibarius from animal cecum in Zhejiang, China. Journal of Global Antimicrobial Resistance. 2022, 29:124-130.
23. Tang B#, Chang J#, Luo Y, Jiang H, Liu C, Xiao X, Ji X, Yang H*. Prevalence and characteristics of the mcr-1 gene in retail meat samples in Zhejiang Province, China. Journal of Microbiology. 2022, 60(6):610-619.
24. Lin J, Tang B*, Zheng X, Chang J, Ma J, He Y, Yang H, Wu Y*. Emergence of Incl2 plasmid-mediated colistin resistance in avian Escherichia fergusonii. FEMS Microbiology Letters. 2022, 369(1):fnac016.
在禽源弗格森埃希菌中发现IncI2型质粒介导黏菌素耐药性
25. Zhou W#, Lin R#, Zhou Z, Ma J, Lin H, Zheng X, Wang J, Wu J, Dong Y, Jiang H, Yang H, Yang Z*, Tang B*, Yue M*. Antimicrobial resistance and genomic characterization of Escherichia coli from pigs and chickens in Zhejiang, China. Frontiers in Microbiology. 2022, 13:1018682.
26. Li Y#, Ed-Dra A#, Tang B#, Kang X#, Müller A, Kehrenberg C, Jia C, Pan H, Yang H, Yue M. Higher tolerance of predominant Salmonella serovars circulating in the antibiotic-free feed farms to environmental stresses. Journal of Hazardous Materials. 2022, 438:129476.
27. Wang J#, Zheng Z#, Yang H, Chen J, Xiao Y, Ji X, Zhang Z, He H, Ding B*, Tang B*. Effect of β-1,3/1,6-glucan on gut microbiota of yellow-feathered broilers. AMB Express. 2022, 12(1):115.
28. Tang B#, Wang Y, Luo Y, Zheng X, Qin X, Yang H*, Shen Z*. Coexistence of optrA and fexA in Campylobacter. Msphere. 2021, 6(3):10-128.
发现恶唑烷酮耐药基因optrA 和氟苯尼考耐药基因 fexA在弯曲杆菌中的共存
29. Tang B#, Ma Y, He X, Zhou Q, Chang J, Qian M, Xia X*, Yang H*. Similar antimicrobial resistance of Escherichia coli strains isolated from retail chickens and poultry farms. Foodborne Pathogens and Disease. 2021, 18(7):489-96.
30. Umar Z#, Chen Q#, Tang B#, Xu Y, Wang J, Zhang H, Ji K, Jia X, Feng Y. The poultry pathogen Riemerella anatipestifer appears as a reservoir for Tet(X) tigecycline resistance. Environmental Microbiology. 2021, 23(12):7465-82.
31. Tang B#, Yang H#, Jia X, Feng Y*. Coexistence and characterization of Tet(X5) and NDM-3 in the MDR-Acinetobacter indicus of duck origin. Microbial Pathogenesis. 2021, 150:104697.
32. Tang B#, Tang Y#, Zhang L, Liu X, Chang J, Xia X, Yang H*, Shen Z*. Emergence of fexA in mediating resistance to florfenicols in Campylobacter. Antimicrobial Agents and Chemotherapy. 2020, 64(7):10-128.
首次发现弯曲杆菌中出现携带氟苯尼考耐药基因fexA的质粒
33. Chang J#, Tang B#, Chen Y, Xia X, Qian M, Yang H*. Two IncHI2 plasmid-mediated colistin-resistant Escherichia coli strains from the broiler chicken supply chain in Zhejiang province, China. Journal of Food Protection. 2020, 83(8):1402-10.
34. Tang B, Chang J, Zhang L, Liu L, Xia X, Hassan BH, Jia X, Yang H*, Feng Y*. Carriage of distinct mcr-1-harboring plasmids by unusual serotypes of Salmonella. Advanced Biosystems. 2020, 4(3):1900219.
35. Tang B, Chen Y, Zhang L, Chang J, Xia X, Yang H*. Complete genome sequence of colistin-resistant Escherichia fergusonii strain EFCF056. Microbiology Resource Announcements. 2020, 9(6):e01571-19.
36. Tang B#, Yu Y*, Liang J, Zhang Y, Bian X, Zhi X*, Ding X*. Reclassification of 'Polyangium brachysporum' DSM 7029 as Schlegelella brevitalea sp. nov. International Journal of Systematic and Evolutionary Microbiology. 2019, 69(9): 2877-2883.
37. Tang B#, Chang J#, Cao L, Luo Q, Xu H, Lyu W, Qian M, Ji X, Zhang Q, Xia X*, Yang H*. Characterization of an NDM-5 carbapenemase-producing Escherichia coli ST156 isolate from a poultry farm in Zhejiang, China. BMC Microbiology. 2019, 19: 82.
38. Yu Y#, Tang B#, Dai R, Zhang B, Chen L, Yang H, Zhao GP*, Ding X*. Identification of the streptothricin and tunicamycin biosynthetic gene clusters by genome mining in Streptomyces sp. strain fd1-xmd. Applied Microbiology and Biotechnology. 2018, 102(6): 2621-2633.
39. Bian X#, Tang B#, Yu Y, Tu Q, Gross F, Wang H, Li A, Fu J, Shen Y, Li YZ, Stewart AF, Zhao GP, Ding X*, Müller R*, Zhang Y*. Heterologous production and yield improvement of epothilones in Burkholderiales strain DSM 7029. ACS Chemical Biology. 2017, 12(7): 1805-1812.
40. Wang X#, Tang B#, Ye Y, Mao Y, Lei X, Zhao GP*, Ding X*. Bxb1 integrase serves as a highly efficient DNA recombinase in rapid metabolite pathway assembly. Acta Biochimica et Biophysica Sinica. 2017, 49(1):44-50.
41. Tang B#, Xie F, Zhao W, Wang J, Dai S, Zheng H, Ding X, Cen X, Liu H, Yu Y, Zhou H, Zhou Y, Zhang L*, Goodfellow M*, Zhao GP*. A systematic study of the whole genome sequence of Amycolatopsis methanolica strain 239T provides an insight into its physiological and taxonomic properties which correlate with its position in the genus. Synthetic and Systems Biotechnology. 2016, 1(3): 169-186.
42. Tang B#, Yu Y#, Zhi X, Yang L, Cen X, Zhao GP*, Ding X*. Streptomyces yangpuensis sp nov.. isolated from soil. International Journal of Systematic and Evolutionary Microbiology. 2016, 66(3): 1224-1229.
43. Tang B#, Yu Y#, Cen X, Zhu Y, Dai R, Wang X, Zhao GP*, Ding X*. Draft genome sequence of the streptothricin-producing strain Streptomyces sp. fd2-tb. Genome announcements. 2015, 3(5):e01277-15.
44. Tang B#, Yu Y#, Zhang Y*, Zhao GP*, Ding X*. Complete genome sequence of the glidobactin producing strain [Polyangium] brachysporum DSM 7029. Journal of Biotechnology. 2015, 210: 83-84.
45. Tang B#, Wang Q#, Yang M, Xie F, Zhu Y, Zhuo Y, Wang S, Gao H, Ding X, Zhang L*, Zhao GP*, Zheng H*. ContigScape: a Cytoscape plugin facilitating microbial genome gap closing. BMC Genomics. 2013, 14: 289-289.
46. Tang B#, Zhao W#, Zheng H, Zhuo Y, Zhang L, Zhao GP*. Complete Genome Sequence of Amycolatopsis mediterranei S699 Based on De Novo Assembly via a Combinatorial Sequencing Strategy. Journal of Bacteriology. 2012, 194(20): 5699-5700.
授权发明专利
1. 一种鉴定拟无枝酸菌的检测方法，专利号ZL202110164167.1，排名第一
2. 一种异源表达埃博霉素的方法，专利号ZL201710090318.7，排名第三
3. 基于傅里叶变换红外光谱的微生物分型系统在乳酸菌分型或乳酸菌类益生菌筛选中的用途，专利号ZL202111390919.2，排名第四
4. 一种菌群耐药性强度评估方法，专利号ZL 202011298198.8，排名十三
5. 一种畜禽养殖过程中抗菌药使用减量化测算方法ZL 202010191094.0，排名十三
其他业绩
主持制定学会团体标准4项，软件著作权11件；联合培养研究生10余名。
学术兼职
委员（2023-），浙江省药学会微生物耐药与控制专业委员会
委员（2023-），浙江省青年微生物学会
学术期刊
编委（2024-），BMC Microbiology; Editorial Board Member
编委（2024-），Scientific Reports; Editorial Board Member
编委（2022-），Frontiers in Microbiology; Associate Editor
青年编委（2024-），Engineering Microbiology
青年编委（2024-），Decoding Infection and Transmission
青年编委（2024-），Advanced Biotechnology
个人学术网页
https://orcid.org/0000-0002-3605-4022
https://loop.frontiersin.org/people/1402996/publications
https://scholar.google.com/citations?user=CF-aoqIAAAAJ&hl=en
