万漪 特聘研究员
邮箱：yiwan@ucas.ac.cn
导师简介
万漪，国家海外高层次青年人才计划入选者，特聘研究员，博士生导师。2018年博士毕业于浙江大学，随后在哈佛大学陈曾熙公共卫生学院营养系从事博士后研究（师从Walter C. Willett和Frank B. Hu），25年初加入国科大杭高院生命与健康科学学院。主要通过开展人群干预试验和整合前瞻性队列研究，结合多组学分析，探究营养与人类健康的关系，并从营养-肠道健康-人类遗传的互作角度，研究人体对膳食模式/食物/食品的差异化应答，构建基于个体化应答的营养干预策略。至今在BMJ、Gut、Diabetes Care、Gut Microbes、EbioMedicine和Clinical Nutrition等权威期刊上发表了多篇论文。
研究方向：精准营养、营养流行病学、食品营养
课题组以营养与人类健康为研究中心，在人群水平开展以下研究：
1）通过开展营养干预试验，结合新型可穿戴设备，探究营养（营养素、膳食模式、植物活性成分、营养补充剂等）对人类健康的影响及相关分子机制，提供人群研究的直接证据，并从营养-肠道健康-人类遗传的互作角度，研究人体对食物的差异化应答，构建基于个体化应答的精准营养指导方案。
2）通过对特定人群开展靶向临床干预，评估开发基于个体化应答的精准营养指导方案或辅助疗法。
3）整合随机对照试验和前瞻性队列研究，结合多组学大数据（基因组、肠道微生物、代谢组和蛋白组等），发现慢性疾病发生发展的新型生物标记物和干预靶点，探究营养影响健康的中介分子机制。
课题组长期招收副研究员/助理研究员/博士后，详见http://hias.ucas.ac.cn/life/info/1440/2123.htm
教育背景和工作经历
2008年9月- 2012年6月 福建农林大学食品质量与安全专业
2012年9月- 2014年6月 福建农林大学食品工程专业
2014年9月- 2018年3月 浙江大学食品科学专业
2018年4月- 2019年8月 浙江大学生物系统工程与食品科学学院
2019年9月- 2025年1月 哈佛大学陈曾熙公共卫生学院营养系
2025年3月-至今 国科大杭州高等研究院生命和健康科学学院
代表性论著
1.Wan Y, Tobias DK, Dennis KK, et al., Association between changes in carbohydrate intake and long term weight change: prospective cohort study. The BMJ 2023;382:e073939
2.Wan Y, Tabung FK, Lee DH, et al., Dietary insulinemic potential and risk of total and cause-specific mortality in the Nurses' Health Study and the Health Professionals Follow-up Study. Diabetes Care 2022;45(2):451-459
3.Wan Y, Wu K, Wang L, et al., Dietary fat and fatty acids in relation to risk of colorectal cancer. European Journal of Nutrition 2022;61(4):1863-1873
4.Wan Y, Jiang J, Lu M, et al., Human milk microbiota development during lactation and its relation to maternal geographic location and gestational hypertensive status. Gut Microbes 2020;11(5):1438-1449
5.Wan Y, Tang J, Li J, et al., Contribution of diet to gut microbiota and related host cardiometabolic health: The diet-gut axis in human health. Gut Microbes 2020;11(3):603-609
6.Wan Y, Li H, Li J, et al., Overweight and underweight status are linked to specific gut microbiota and intestinal tricarboxylic acid cycle intermediates. Clinical Nutrition 2020;39(10):3189-3198
7.Wan Y, Yuan J, Li J, et al., Unconjugated and secondary bile acid profiles in response to higher-fat, lower-carbohydrate diet and associated with related gut microbiota: a 6-month randomized controlled-feeding trial. Clinical Nutrition 2020;39(2):395-404
8.Wan Y, Tong W, Zhou R, et al., Habitual animal fat consumption in shaping gut microbiota and microbial metabolites. Food & Function 2019;10(12):7973-7982
9.Wang F*, Wan Y*, Yin K, et al., Lower circulating branched-chain amino acid concentrations among vegetarians are associated with changes in gut microbial composition and function. Molecular Nutrition & Food Research 2019;63(24):e1900612 (* contributed equally)
10.Wan Y*, Wang F*, Yuan J, et al., Effects of dietary fat on gut microbiota and faecal metabolites, and their relationship with cardiometabolic risk factors: a 6-month randomised controlled-feeding trial. Gut 2019;68:1417-1429 (* contributed equally)
11.Wan Y, Fu Y, Wang F, et al., Protective Effects of a Lipid Extract from Hard-Shelled Mussel (Mytilus coruscus) on Intestinal Integrity after Lipopolysaccharide Challenge in Mice. Nutrients 2018;10(7):860
12.Lu M*, Wan Y*, Yang B, et al., Effects of low-fat compared with high-fat diet on cardiometabolic indicators in people with overweight and obesity without overt metabolic disturbance: a systematic review and meta-analysis of randomised controlled trials. British Journal of Nutrition 2018;119(1):96-108 (* contributed equally)
13.Wan Y*, Wang F*, Yuan J, et al., Effects of macronutrient distribution on weight and related cardiometabolic profile in healthy non-obese Chinese: a 6-month, randomized controlled-feeding trial. EBioMedicine 2017;22:200-207 (* contributed equally)
14.Wan Y, Wang F, Yuan J, et al., Optimal dietary macronutrient distribution in China (ODMDC): A randomised controlled-feeding trial protocol. Asia Pacific Journal of Clinical Nutrition 2017;26(5):972-980
15.Wan Y, Zheng J, Wang F, et al., Fish, long chain omega-3 polyunsaturated fatty acids consumption, and risk of all-cause mortality: a systematic review and dose-response meta-analysis from 23 independent prospective cohort studies. Asia Pacific Journal of Clinical Nutrition 2017;26(5):939-956
