蔡车国
教授
邮箱：cheguo_cai@ucas.ac.cn
研究领域：乳腺发育，乳腺癌
招生专业：发育生物学，细胞生物学
教育背景
（1）1998/09 - 2005/07：厦门大学， 本科/硕士
（2）2007/09 - 2010/07：中科院上海巴斯德研究所，博士
工作经历
（1）2005/08 - 2007/08：中科院上海巴斯德研究所，科研助理
（2）2010/10 - 2011/09：美国杜兰大学，博士后
（3）2011/10 - 2015/03：中科院上海生物化学与细胞生物学研究所，博士后
（4）2015/04 - 2017/01：中科院上海生物化学与细胞生物学研究所，副教授
（5）2017/02 - 2022/11：武汉大学医学研究院/教育部免疫与代谢前沿科学中心/武汉大学中南医院，教授/博士生导师
（6）2022/12 - 至今 ：国科大杭州高等研究院，教授/博士生导师
代表性文章
1.Yu Zhou*, Zi Ye, Liya Yu, Cheguo Cai#; Macrophages maintain mammary stem cell activity and mammary homeostasis via TNF-α-Cdk1/Cyclin B1 axis. npj Regenerative Medicine, 2022, (revision)
2.Mengna Zhang*, Lingxian Zhang*, Ajun Geng*, Xiao Li, Yu Zhou, Liming Xu, Yi Arial Zeng#, Jinpeng Li#, Cheguo Cai#; CDK14 inhibition reduces mammary stem cell activity and suppresses triple negative breast cancer progression. Cell Reports, 2022, 40(11).
3.Xiao Li*, Jinpeng Li*, Liming Xu, Wei Wei, Anyi Cheng, Lingxian Zhang, Mengna Zhang, Gaosong Wu#, Cheguo Cai#; CDK16 promotes the progression and metastasis of triple-negative breast cancer by phosphorylating PRC1. J Exp Clin Cancer Res, 2022, 41(1).
4.Ruirui Wang, Fujing Huang, Cheguo Cai#; Programmed Cell Death Ligand 1 is enriched in mammary stem cells and promotes mammary development and regeneration, Front Cell Dev Biol, 2021.
5.Weizhen Chen, Wei Wei, Cheguo Cai#; Mammary Development and Breast Cancer: a Notch Perspective, J Mammary Gland Biol Neoplasia, 2021.
6.Weizhen Chen, Cheguo Cai#; Baicalin Promotes Mammary Gland Development via Steroid-Like Activities, Front Cell Dev Biol, 2021.
7.Mengna Zhang, Cheguo Cai#; CDK inhibitors in cancer therapy, an overview of recent development, Am J Cancer Res, 2021.
8.Ajun Geng*; Ting Wu*, Cheguo Cai*; Yi Arial Zeng#; A Novel Function of Rspondin1 in Regulating Estrogen Receptor Expression Independent of Wnt/β-Catenin Signaling, eLife, 2020. (Co-First).
9.Cheguo Cai; Yi Arial Zeng#; Amphiregulin mediates the hormonal regulation on Rspondin-1 expression in the mammary gland, Dev Biol, 2019.
10.Liyong Zeng*; Cheguo Cai*; Shan Li; Wenjuan Wang; Yaping Li; Jiangye Chen; Xueliang Zhu#; Yi Arial Zeng#; Essential Roles of Cyclin Y-Like 1 andCyclin Y in Dividing Wnt-Responsive Mammary Stem/Progenitor Cells, PLoS Genetics, 2016. (Co-First).
11.Daisong Wang*; Cheguo Cai*; Xiaobing Dong; Yi Arial Zeng#; Identification of multipotent mammary stem cells by protein C receptor expression, Nature, 2015. (Co-First).
12.Cheguo Cai; Qing Cissy Yu; Yi Arial Zeng#; R-spondin1 is a novel hormone mediator for mammary stem cell self-renewal, Genes & Development, 2014.
研究方向
蔡车国，国科大杭高院生命与健康科学学院教授，主要研究领域是乳腺上皮与微环境之间的相互作用及其对乳腺发育的分子调控，乳腺癌发生的分子机理及乳腺癌治疗的新策略等。在Nature、Genes & Development、Cell Reports、J Exp Clin Cancer Res、eLife等杂志发表SCI论文20余篇。现为国际干细胞学会会员（ISSCR），中国细胞生物学学会会员（CSCB），中国抗癌协会会员等。
