李智海

李智海

工作经历

2021.09-至今         国科大杭州高等研究院 药物科学与技术学院 副研究员

2020.10-2021.08   中国科学院上海药物研究所 药物靶标结构与功能中心 副研究员

2018.01-2020.09   中国科学院上海药物研究所 冷冻电镜技术研究中心 博士后

2016.02-2017.02   美国加州大学洛杉矶分校 访问学者

研究方向

生物大分子复合物动态调控结构药理研究与新药发现，主要围绕与重大疾病相关的病毒感染与复制过程调控、蛋白质稳态调控等相关功能靶点复合物（体）展开结构与功能研究，并开展基于新机制、新靶点的药物研发。

 科研成果

以第一作者（含共同）在Cell Research（2篇）, Nature Structural & Molecular Biology, Nature Communication（3篇）, Protein & Cell, mBio等期刊发表SCI论文11篇，申请中国或国际发明专利10余项，其中获授权9项。
     1.Li Z.*, Pang J.*, Gao R., Wang Q., Zhang M. & Yu X.#. Cryo-electron microscopy structures of capsids and in situ portals of DNA-devoid capsids of human cytomegalovirus. Nature Communications 2023, 14: 2025. （亮点推荐）
     2.Li Z.*, Pang J.*, Dong L.* & Yu X.#. Structural basis for genome packaging, retention, and ejection in human cytomegalovirus. Nature Communications 2021, 12: 4538.（亮点推荐）
     3.Yin W.*, Luan X.*, Li Z.*, Zhou Z.*, Wang Q.*, Gao M., Wang X., Zhou F., Shi J., You E., Liu M., Wang Q., Jiang Y., Jiang H., Xiao G., Zhang L.#, Yu X.#, Zhang S.# & Xu H.E.#. Structural basis for inhibition of the SARS-CoV-2 RNA polymerase by suramin. Nature Structural & Molecular Biology 2021, 28: 319-325.
     4.Li Z.*, Zhang X.*, Dong L., Pang J., Xu M., Zhong Q., Zeng M.S.# & Yu X.#. CryoEM structure of the tegumented capsid of Epstein-Barr virus. Cell Research 2020, 30(10):873-884.（封面文章）
     5.Li Z. & Yu X.#. Progress towards revealing the mechanism of herpesvirus capsid maturation and genome packaging. Protein & Cell 2020, 11:316-317.
     6.Yin W*, Li Z.*, Jin M.*, Yin Y.L.*, Waal P.W., Pal K., Yin Y., Gao X., He Y., Gao J., Wang X., Zhang Y., Zhou H., Melcher K., Jiang Y., Cong Y.#, Zhou X.E.#, Yu X.# & Xu H.E.#. A complex structure of arrestin-2 bound to a G-protein-coupled receptor. Cell Research 2019, 29(12):971–983.
     7.Li Z.*, Song S.*, He M.*, Wang D., Shi J., Liu X., Li Y., Chi X., Wei S., Yang Y., Wang Z., Li J., Qian H., Yu H., Zheng Q., Yan X., Zhao Q., Zhang J., Gu Y.#, Li S.# & Xia N.#. Rational Design of a Triple-Type Human Papillomavirus Vaccine by Compromising Viral-Type Specificity. Nature Communications 2018, 9(1):5360.
     8.Wei M.*, Wang D.*, Li Z.*, Song S., Kong X., Mo X., Yang Y., He M., Li Z., Huang B., Lin Z., Pan H., Zheng Q., Yu H., Zhang J., Li S.# & Xia N.#. N-terminal Truncations on L1 Proteins of Human Papillomaviruses Promote their Soluble Expression in Escherichia coli and Self-assembly in Vitro. Emerging Microbes & Infections 2018, 7(1):160.
     9.Li Z.*, Wang D.*, Gu Y.*, Song S., He M., Shi J., Liu X., Wei S., Li J., Yu H., Zheng Q., Yan X., Baker T.S., Zhang J., McLellan J.S.#, Li S.# & Xia N.#. Crystal Structures of Two Immune Complexes Identify Determinants for Viral Infectivity and Type-specific Neutralization of Human Papillomavirus. mBio 2017, 8: e00787-17.
     10.Pan H.*, Li Z.*, Wang J., Song S., Wang D., Wei M., Gu Y., Zhang J., Li S.# & Xia N.#. Bacterially expressed human papillomavirus type 6 and 11 bivalent vaccine: Characterization, antigenicity and immunogenicity. Vaccine 2017, 35: 3221-3231.
     11.Li Z.*, Yan X.*, Yu H.*, Wang D., Song S., Li Y., He M., Hong Q., Zheng Q., Zhao Q., Gu Y., Zhang J., Janssen M.E.W, Cardone G., Olson N.H., Baker T.S.#, Li S.# & Xia N.#. The C-Terminal Arm of the Human Papillomavirus Major Capsid Protein Is Immunogenic and Involved in Virus-Host Interaction. Structure 2016, 24: 874-885.
     12.Dai X. Li Z., Lai M., Shu S., Du Y., Zhou H.# & Sun R.#. In situ structures of the genome and genome-delivery apparatus in an ssRNA virus. Nature 2017, 541: 112–116.