李淳朴

个人信息：

李淳朴 博士

研究员，国科大杭州高等研究院

浙江省杭州市西湖区象山支路1号 310012

E-mail: lichunpu@simm.ac.cn

教育背景：

2010-09 至 2015-07, 中国药科大学, 药物化学, 博士

2006-09 至 2010-07, 中国药科大学, 药学, 学士

工作经历：

2022-11 至 今，中国科学院上海药物研究所，研究员

2017-11 至 2022-10，中国科学院上海药物研究所，副研究员

2017-08 至 2017-10，中国科学院上海药物研究所，助理研究员

2015-08 至 2017-07，中因科学院上海药物研究所，博士后

研究方向：

1. 针对肿瘤的创新药物研究

2. 开发高效合成技术构建类药性杂环、含氟化合物库

代表性研究成果：

1. 1.Zichao Xu^#, Xia Peng^#, Renjie Zhang, Yinchun Ji, Mengke You, Danyi Wang, Yanyan Shen, Mingyue Zheng, Chunpu Li^*, Jing Ai^*, Hong Liu^*. Discovery, Optimization, and Evaluation of Novel Pyridin-2(1H)-one Analogues as Potent TRK Inhibitors for Cancer Treatment. Journal of Medicinal Chemistry, 2024, 67, 1168-1183.

2. 2.Chunpu li^#, Yang Dai^#, Xiangtai Kong^#, Bao Wang^#, Xia Peng, Hengbo Wu, Yanyan Shen, Yanchen Yang, Yinchun Ji, Danyi Wang, Shuangjie Li, Xutong Li, Yuqiang Shi, Meiyu Geng, Mingyue Zheng^*, Jing Ai^*, Hong Liu^*. Structural Optimization of Fibroblast Growth Factor Receptor Inhibitors for Treating Solid Tumors. Journal of Medicinal Chemistry, 2023, 66, 3226-3249.

   3.Yue Zhao, Yangpeng Shen, Jian He, Jing Li, Shengbin Zhou, Yunbo Wang, Chunpu li^*, Hong Liu^*. Late-Stage functionalization for the divergent synthesis of novel podophyllotoxin derivatives by rhodium catalysis. Chemistry-A European Journal, 2023, e202300960.

3. 4.Chunpu li^#, Mingbo Su^#, Wei Zhu^#, Weijuan Kan, Tianpeng Ge, Gaoya Xu, Shuni Wang, Li Sheng, Feng Gao, Yunfei Ye, Jiang Wang, Yubo Zhou^*, Jia Li^* and Hong Liu^*. Structure−Activity Relationship Study of Indolin-5-yl-cyclopropanamine Derivatives as Selective Lysine Specific Demethylase 1 (LSD1) Inhibitors. Journal of Medicinal Chemistry, 2022, 65, 4335-4349.

4. 5.Xiaoqin Tan^#, Chunpu li^#, Ruirui Yang^#, Sen Zhao, Fei Li, Xutong Li, Lifan Chen, Xiaozhe Wan, Xiaohong Liu, Tianbiao Yang, Xiaochu Tong, Tingyang Xu, Rongrong Cui, Hualiang Jiang, Sulin Zhang^*, Hong Liu^*, Mingyue Zheng^*. Discovery of Pyrazolo[3,4‑d]pyridazinone Derivatives as Selective DDR1 Inhibitors via Deep Learning Based Design, Synthesis, and Biological Evaluation. Journal of Medicinal Chemistry, 2022, 65, 103-119.

5. 6.Chunpu li^#, Sha-Sha Hu^#, Lisheng Yang^#, Min Wang, Jian-Dong Long, Bing Wang, Haozhen Han, Haoran Zhu, Sen Zhao, Jing-Gen Liu^*, Dongxiang Liu^* and Hong Liu^*. Discovery of 5‑Benzylidene-2-phenyl-1,3-dioxane-4,6-diones as Highly Potent and Selective SIRT1 Inhibitors. ACS Medicinal Chemistry Letters, 2021, 12, 397-403.

6. 7.Xuewu Liang^#, Chenxia Sun^#, Chunpu li^#, Haolan Yu^#, Xiaohui Wei, Xuyi Liu, Wei Bao, Yuqiang Shi, Xiaochen Sun, Mirzadavlat Khamrakulov, Chenghua Yang^* and Hong Liu^*. Identification of Novel Fused Heteroaromatics-Based MALT1 Inhibitors by High-Throughput Screening to Treat B Cell Lymphoma. Journal of Medicinal Chemistry, 2021, 64, 9217-9237.

7. 8.Chengfei Liu^#, Chunpu li^#, Cui Pang, Muqiong Li, Huixin Li, Pengxiang Li, Li Fan^*, Hong Liu^* and Wei Tian^*. Supramolecular Drug-Drug Complex Vesicles Enable Sequential Drug Release for Enhanced Combination Therapy. ACS Applied Materials & Interfaces, 2020, 12, 27940-27950.

8. 9.Lisheng Yang^#, Chunpu li^#, Dechuan Wang^* and Hong Liu^*. Cp*Rh(III)-Catalyzed C-H Bond Difluorovinylation of Indoles with α,α-Difluorovinyl Tosylate. Journal of Organic Chemistry, 2019, 84, 7320-7330.

9. 10.Yang Gao, Chunpu li^*, Bin Xu and Hong Liu^*. Rapid Access to Difluoroalkylated Pyrrolobenzodiazepines via a Pd-catalyzed C-H Difluoroalkylation/Cyclization Cascade Reaction. Organic Chemistry Frontiers, 2019, 6, 410-414.

10. 11.Xiao Fei^#, Chunpu li^#, Xinhong Yu^* and Hong Liu^*. Rh(III)-Catalyzed Hydroarylation of Alkyne MIDA Boronates via C−H Activation of Indole Derivatives. Journal of Organic Chemistry, 2019, 84, 6840-6850.

11. 12.Bao Wang^#, Chunpu li^#, Hong Liu^*. Cp^*Rh(III)-Catalyzed Directed C-H Methylation and Arylation of Quinoline N-Oxides at the C-8 Position. Advanced Synthesis & Catalysis, 2017, 359, 3029-3034.

12. 13.Chunpu li^#, Dengyou Zhang^#, Wei Zhu, Penghui Wan, and Hong Liu^*. Pd(II)-catalyzed direct functionalization of C-H bonds of benzamides for synthesis of 1,1-difluoro-l-alkenes. Organic Chemistry Frontiers, 2016, 3, 1080-1083.

13. 14.Chunpu li^#, Jing Ai^#, Dengyou Zhang^#, Xia Peng, Xi Chen, Zhiwei Gao, Yi Su, Wei Zhu, Yinchun Ji, Xiaoyan Chen, Meiyu Geng^* and Hong Liu^* Design, Synthesis and Biological Evaluation of Novel Imidazo[1,2-a]pyridine Derivatives as Potent c-Met Inhibitors. ACS Medicinal Chemistry Letters, 2015, 6, 507-512.