雷赛飞

雷赛飞  博士

特聘副研究员，国科大杭州高等研究院

浙江省杭州市西湖区象山支路1号                                    

Email:leisaifei@ucas.ac.cn

教育背景：

2009.09－2013.07，中央民族大学，制药工程，工学学士

2016.01－2016.12，澳大利亚莫纳什大学，药物科学研究所，联合培养

2013.09－2019.04，中科院上海药物研究所，药理学，博士

工作经历：

2019.05－2020.07，美国匹兹堡大学，医学院，博士后

2020.08－2023.07，美国匹兹堡大学，药学院，博士后

2024.10－至今，国科大杭州高等研究院，特聘副研究员

研究方向：

代谢相关疾病的致病机理研究和药物开发，包括：

1. 肝脏疾病致病机理研究、靶点发现和药物开发；

2. 膜受体、核受体的结构、功能以及作用机制研究；

代表性研究成果：

1. 1.Yue Zhang, Jie Liang, Hao Gu, Ting Du, Pengfei Xu, Ting Yu, Qing He, Zhenyao Huang, Saifei Lei*, Jing Li*. Activation of LXRa attenuates 2-Ethylhexyl diphenyl phosphate (EHDPP) induced placental dysfunction. ECTOX ENVIRON SAFE. 2023;266.

2. 2.Saifei Lei,  Qian Qi, Alice Guo, Jie Lu, Aaron S. Devanathan, Junjie Zhu, Xiaochao Ma. Activation of PXR causes drug interactions with Paxlovid in transgenic mice. 2023. Acta Pharmaceutica Sinica B, 2023;13(11):4502-4510.

3. 3.Saifei Lei, Lachlan Clydesdale, Antao Dai, Xiaoqing Cai, Yang Feng, Dehua Yang,Yi-Lynn Liang, Cassandra Koole, Peishen Zhao, Thomas Coudrat, Arthur Christopoulos, Ming-Wei Wang, Denise Wootten, Patrick M Sexton. Two distinct domains of the  glucagon-like peptide-1 receptor control peptide-mediated biased agonism. J Biol Chem. 2018;293:9370-87.

4. 4.Saifei Lei, Dehua Yang, Ming-Wei Wang. A historic study that opened a new chapter in nutritional science. Acta Pharmacol Sin. 2016;37:1641-4.

5. 5.Saifei Lei, Jie Lu, Anqi Cheng, Zahir Hussain, Kevin Tidgewell, Junjie Zhu, Xiaochao Ma. Identification of PXR activators from Uncaria rhynchophylla (Gou Teng) and Uncaria tomentosa (Cat's Claw). Drug Metab Dispos. 2023;51(5):629-36.

6. 6.Saifei Lei, Qian Meng, Yanyun Liu, Qiaofeng Liu, Antao Dai, Xiaoqing Cai, Ming-Wei Wang, Qingtong Zhou, Hu Zhou, Dehua Yang. Distinct roles of the extracellular surface residues of glucagon-like peptide-1 receptor in β-arrestin 1/2 signaling. European Journal of Pharmacology.Epub 2024 Feb 13.

7. 7.Saifei Lei, Ruizhi Gu, Xiaochao Ma. Clinical perspectives of isoniazid-induced liver injury. Liver research. 2021;5:45-52.

8. 8.Alex D White, Karina A Peña, Lisa J. Clark, Christian Santa Maria, Shi Liu, Frederic G. Jean-Alphonse, Ji Young Lee, Saifei Lei, Zhiqiang Cheng, Chia-Ling Tu, Fei Fang, Nicholas Szeto, Thomas J Gardella, Kunhong Xiao, Samuel H Gellman, Ivet Bahar, Ieva Sutkeviciute, Wenhan Chang, Jean-Pierre Vilardaga. Spatial bias in cAMP generation determines biological responses to PTH type 1 receptor activation. Sci Signal. 2021;14:eabc5944.  

9. 9.Yi-Lynn Liang, Maryam Khoshouei, Alisa Glukhova, Sebastian G.B. Furness, Peishen Zhao, Lachlan Clydesdale, Cassandra Koole, Tin T. Truong, David M. Thal, Saifei Lei, Mazdak Radjainia, Radostin Danev, Wolfgang Baumeister, Ming-Wei Wang, Laurence J Miller, Authur Christopoulos, Patrick M. Sexton, Denise Wootten. Phase-plate cryo-EM structure of a biased agonist-bound human GLP-1 receptor-Gs complex. Nature. 2018; 555:121-125.

10. 10.Lisa J. Clark, James Krieger, Alex D. White, Vasyl Bondarenko, Saifei Lei, Fei Fang, Ji Young Lee, Pemra Doruker, Thore Böttke, Frederic G. Jean-Alphonse, Pei Tang, Thomas J. Gardella, Kunhong Xiao, Ieva Sutkeviciute, Irene Coin, Ivet Bahar, Jean-Pierre Vilardaga.  Allosteric interactions in the parathyroid hormone GPCR-arrestin complex formation. Nat Chem Biol, 2020;16:1096-1104.

11. 11.Ieva Sutkeviciute, Ji Young Lee, Alex D. White, Christian Santa Maria, Karina A. Peña, Sofya Savransky, Pemra Doruker, Hongchun Li, Saifei Lei, Burak Kaynak, Chialing Tu, Lisa J Clark, Subramaniam Sanker, Thomas J Gardella, Wenhan Chang, Ivet Bahar, Jean-Pierre Vilardaga. Precise druggability of the PTH type 1 receptor. Nat Chem Biol. 2022;18:272-280.

12. 12.Jing Li, Xiaojie Quan, Saifei Lei, Gang Chen, Jiawei Hong, Zhenyao Huang, Qi Wang, Weiyi Song, Xinxin Yang. LncRNA MEG3 alleviates PFOS induced placental cell growth inhibition through its derived miR-770 targeting PTX3. Environ Pollut, 2022; 293: p. 118542.

13. 13.Jing Li , Xiaojie Quan , Yue Zhang, Ting Yu , Saifei Lei, Zhenyao Huang, Qi Wang, Weiyi Song, Xinxin Yang, Pengfei Xu. PPARgamma Regulates Triclosan Induced Placental Dysfunction. Cells. 2021; 11(1):86.

14. 14.Junjie Zhu, Saifei Lei, Jie Lu, Yixuan Hao, Qi Qian, Aaron S. Devanathan, Zhiwei Feng, Xiang-Qun Xie, Peter Wipf, Xiaochao Ma. Metabolism-guided development of Ko143 analogs as ABCG2 inhibitors. European Journal of Medicinal Chemistry. 2023;115666.

15. 15.Zhengyu Hu, Yan Li, Bingwei Ma, Saifei Lei, Xingchun Wang. Iron metabolism mediates the relationship between Vitamin C and hepatic steatosis and fibrosis in NAFLD. Front Nutr, 2022; 9: p. 952056.

16. 16.Yue Zhu, Ting Xiao, Saifei Lei, Fulai Zhou, Ming-Wei Wang. Application of chemical biology in target identification and drug discovery. Arch Pharm Res. 2015;38:1642-50.

17. 17.Jing Li, Xiaojie Quan, Saifei Lei, Zhenyao Huang, Qi Wang, Pengfei Xu. PFOS Inhibited Normal Functional Development of Placenta Cells via PPARgamma Signaling. Biomedicines. 2021; 9(6):677.

18. 18.Caihong Zhou, Xinchuan Dai, Yi Chen, Yanyan Shen, Saifei Lei, Ting Xiao, Tamas Bartfai, Jian Ding, Ming-Wei Wang. G protein-coupled receptor GPR160 is associated with apoptosis and cell cycle arrest of prostate cancer cells. Oncotarget. 2016; 7:12823-39.

19. 19.Jianhua Li, Zahir Hussain, Junjie Zhu, Saifei Lei, Jie Lu, Xiaochao Ma. Role of CYP2A6 in Methimazole Bioactivation and Hepatotoxicity. Chem Res Toxicol. 2021;34:2534-9.

20. 20.Anqi Cheng, Saifei Lei, Junjie Zhu, Jie Lu, Mary F. Paine, Wen Xie, Xiaochao Ma. Chemical basis of pregnane X receptor activators in the herbal supplement Gancao (licorice). Liver Research, 2022; 6(4),251-7.