李淳朴

2022年04月08日 11:23    吴睿    点击:[]


34B2

个人信息:

李淳朴 博士

研究员,国科大杭州高等研究院

浙江省杭州市西湖区象山支路1号 310012

E-mail: lichunpu@simm.ac.cn


教育背景

2010-09 至 2015-07, 中国药科大学, 药物化学, 博士

2006-09 至 2010-07, 中国药科大学, 药学, 学

 

工作经历:

2022-11 至 今,中国科学院上海药物研究所,研究员

2017-11 至 2022-10,中国科学院上海药物研究所,副研究员

2017-08 至 2017-10,中国科学院上海药物研究所,助理研究员

2015-08 至 2017-07,中因科学院上海药物研究所,博士后


研究方向:

1. 针对肿瘤的创新药物研究

2. 开发高效合成技术构建类药性杂环、含氟化合物库


代表性研究成果

  1. 1.Zichao Xu#, Xia Peng#, Renjie Zhang, Yinchun Ji, Mengke You, Danyi Wang, Yanyan Shen, Mingyue Zheng, Chunpu Li*, Jing Ai*, Hong Liu*. Discovery, Optimization, and Evaluation of Novel Pyridin-2(1H)-one Analogues as Potent TRK Inhibitors for Cancer Treatment. Journal of Medicinal Chemistry, 2024, 67, 1168-1183.

  2. 2.Chunpu li#, Yang Dai#, Xiangtai Kong#, Bao Wang#, Xia Peng, Hengbo Wu, Yanyan Shen, Yanchen Yang, Yinchun Ji, Danyi Wang, Shuangjie Li, Xutong Li, Yuqiang Shi, Meiyu Geng, Mingyue Zheng*, Jing Ai*, Hong Liu*. Structural Optimization of Fibroblast Growth Factor Receptor Inhibitors for Treating Solid Tumors. Journal of Medicinal Chemistry, 2023, 66, 3226-3249.

    3.Yue Zhao, Yangpeng Shen, Jian He, Jing Li, Shengbin Zhou, Yunbo Wang, Chunpu li*, Hong Liu*. Late-Stage functionalization for the divergent synthesis of novel podophyllotoxin derivatives by rhodium catalysis. Chemistry-A European Journal, 2023, e202300960.

  3. 4.Chunpu li#, Mingbo Su#, Wei Zhu#, Weijuan Kan, Tianpeng Ge, Gaoya Xu, Shuni Wang, Li Sheng, Feng Gao, Yunfei Ye, Jiang Wang, Yubo Zhou*, Jia Li* and Hong Liu*. Structure−Activity Relationship Study of Indolin-5-yl-cyclopropanamine Derivatives as Selective Lysine Specific Demethylase 1 (LSD1) Inhibitors. Journal of Medicinal Chemistry, 2022, 65, 4335-4349.

  4. 5.Xiaoqin Tan#, Chunpu li#, Ruirui Yang#, Sen Zhao, Fei Li, Xutong Li, Lifan Chen, Xiaozhe Wan, Xiaohong Liu, Tianbiao Yang, Xiaochu Tong, Tingyang Xu, Rongrong Cui, Hualiang Jiang, Sulin Zhang*, Hong Liu*, Mingyue Zheng*. Discovery of Pyrazolo[3,4‑d]pyridazinone Derivatives as Selective DDR1 Inhibitors via Deep Learning Based Design, Synthesis, and Biological Evaluation. Journal of Medicinal Chemistry, 2022, 65, 103-119.

  5. 6.Chunpu li#, Sha-Sha Hu#, Lisheng Yang#, Min Wang, Jian-Dong Long, Bing Wang, Haozhen Han, Haoran Zhu, Sen Zhao, Jing-Gen Liu*, Dongxiang Liu* and Hong Liu*. Discovery of 5‑Benzylidene-2-phenyl-1,3-dioxane-4,6-diones as Highly Potent and Selective SIRT1 Inhibitors. ACS Medicinal Chemistry Letters, 2021, 12, 397-403.

  6. 7.Xuewu Liang#, Chenxia Sun#, Chunpu li#, Haolan Yu#, Xiaohui Wei, Xuyi Liu, Wei Bao, Yuqiang Shi, Xiaochen Sun, Mirzadavlat Khamrakulov, Chenghua Yang* and Hong Liu*. Identification of Novel Fused Heteroaromatics-Based MALT1 Inhibitors by High-Throughput Screening to Treat B Cell Lymphoma. Journal of Medicinal Chemistry, 2021, 64, 9217-9237.

  7. 8.Chengfei Liu#, Chunpu li#, Cui Pang, Muqiong Li, Huixin Li, Pengxiang Li, Li Fan*, Hong Liu* and Wei Tian*. Supramolecular Drug-Drug Complex Vesicles Enable Sequential Drug Release for Enhanced Combination Therapy. ACS Applied Materials & Interfaces, 2020, 12, 27940-27950.

  8. 9.Lisheng Yang#, Chunpu li#, Dechuan Wang* and Hong Liu*. Cp*Rh(III)-Catalyzed C-H Bond Difluorovinylation of Indoles with α,α-Difluorovinyl Tosylate. Journal of Organic Chemistry, 2019, 84, 7320-7330.

  9. 10.Yang Gao, Chunpu li*, Bin Xu and Hong Liu*. Rapid Access to Difluoroalkylated Pyrrolobenzodiazepines via a Pd-catalyzed C-H Difluoroalkylation/Cyclization Cascade Reaction. Organic Chemistry Frontiers, 2019, 6, 410-414.

  10. 11.Xiao Fei#, Chunpu li#, Xinhong Yu* and Hong Liu*. Rh(III)-Catalyzed Hydroarylation of Alkyne MIDA Boronates via C−H Activation of Indole Derivatives. Journal of Organic Chemistry, 2019, 84, 6840-6850.

  11. 12.Bao Wang#, Chunpu li#, Hong Liu*. Cp*Rh(III)-Catalyzed Directed C-H Methylation and Arylation of Quinoline N-Oxides at the C-8 Position. Advanced Synthesis & Catalysis, 2017, 359, 3029-3034.

  12. 13.Chunpu li#, Dengyou Zhang#, Wei Zhu, Penghui Wan, and Hong Liu*. Pd(II)-catalyzed direct functionalization of C-H bonds of benzamides for synthesis of 1,1-difluoro-l-alkenes. Organic Chemistry Frontiers, 2016, 3, 1080-1083.

  13. 14.Chunpu li#, Jing Ai#, Dengyou Zhang#, Xia Peng, Xi Chen, Zhiwei Gao, Yi Su, Wei Zhu, Yinchun Ji, Xiaoyan Chen, Meiyu Geng* and Hong Liu* Design, Synthesis and Biological Evaluation of Novel Imidazo[1,2-a]pyridine Derivatives as Potent c-Met Inhibitors. ACS Medicinal Chemistry Letters, 2015, 6, 507-512.

     

 

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国科大杭州高等研究院药物科学与技术学院 

电话:0571-86080393 

邮箱:yxy@ucas.ac.cn

国科大杭高院药学院