徐田锋

个人信息：

徐田锋 博士

青年研究员，国科大杭州高等研究院

浙江省杭州市西湖区象山支路1号 310012

Phone: 021-68077826

E-mail: tfxu@simm.ac.cn

教育背景：

2009/09 ~ 2014/07 博士 中国科学院广州生物医药与健康研究院 药物化学

2005/09 ~ 2009/06 学士 山东师范大学 应用化学

工作经历：

2021/01至今 青年研究员 国科大杭州高等研究院

2019/03至今 研究员 中国科学院上海药物研究所

2014/11 ~ 2019/02 博士后 密歇根大学-安娜堡校区

研究方向：

1.可诱导蛋白质降解小分子药物的设计与开发

2.激酶、蛋白-蛋白相互作用抑制剂的设计、合成及成药性修饰

代表性研究成果：

1.Chuan Zhou, Zisheng Fan, Yuejiao Gu, Zhiming Ge, Zhaofan Tao, Rongrong Cui, Yupeng Li, Guizhen Zhou, Ruifeng Huo, Mingshan Gao, Dan Wang, Wei He, Mingyue Zheng, Sulin Zhang, Tianfeng Xu, Design, Synthesis, and Biological Evaluation of Potent and Selective PROTAC degraders of Oncogenic KRAS^G12D, J Med Chem. 2024, 67 (2), 1147-1167.

2.Zehui Zhou, Guizhen Zhou, Chuan Zhou, Zisheng Fan, Rongrong Cui, Yupeng Li, Rui Li, Yuejiao Gu, Huajie Li, Zhiming Ge, Xiaojia Cai, Bing Jiang, Dan Wang, Mingyue Zheng, Tianfeng Xu, Sulin Zhang, Discovery of a Potent, Cooperative, and Selective SOS1 PROTAC ZZ151 with In Vivo Antitumor Efficacy in KRAS-Mutant Cancers, J Med Chem. 2023, 66 (6), 4197-4214.

3.Meiying Liu, Guizhen Zhou, Wenhong Su, Yuejiao Gu, Mingshan Gao, Kun Wang, Ruifeng Huo, Yupeng Li, Zehui Zhou, Kaixian Chen, Mingyue Zheng, Sulin Zhang, Tianfeng Xu, Design, Synthesis and Bioevaluation of Pyrido[2,3-d]pyrimidin-7-ones as Potent SOS1 Inhibitors, Acs Med Chem Lett 2023, 14 (2), 183-190.

4.Chuan Zhou, Zisheng Fan, Zehui Zhou, Yupeng Li, Rongrong Cui, Chaoyi Liu, Guizhen Zhou, Xingxing Diao, Hualiang Jiang, Mingyue Zheng, Sulin Zhang, and Tianfeng Xu, Discovery of the First-in-Class Agonist-Based SOS1 PROTACs Effective in Human Cancer Cells Harboring Various KRAS Mutations, J Med Chem. 2022, 65 (5), 3923-3942.

5.Hualin Zhang, Ruliang Xie, Hawaa AI-furas, Yupeng Li, Qingxia Wu, Jian Li, Fang Xu, and Tianfeng Xu, Design, Synthesis, and Biological Evaluation of Novel EGFR PROTACs Targeting Del19/T790M/C797S Mutation, Acs Med Chem Lett 2022, 13 (2), 278-283.