杨财广

个人信息：

杨财广 博士

研究员，国科大杭州高等研究院

上海市浦东新区祖冲之路555号  

Phone: 021-68077945

E-mail: yangcg@simm.ac.cn

教育背景：

1997.09-2002.07 中科院上海有机化学研究所，有机化学博士；

1993.09-1997.07 华中理工大学化学系，学士.

工作经历：

2008.05-至今 中国科学院上海药物研究所，课题组长、中心主任；

2020.01-至今  国科大杭州高等研究院，课题组长、研究员；

2002.12-2008.04 芝加哥大学化学系，博士后

研究方向：

基于化学遗传学的原创新药发现研究；

靶向RNA表观遗传的化学探针与靶标成药性研究；

小分子靶向性干预线粒体蛋白质稳态抗肿瘤；

新类型抗生素以及运用“非抗生素效应”抗耐药菌感染；

代表性研究成果：

1.Lin-Lin Zhou^#, Tao Zhang^#, Yun Xue^#, Chuan Yue, Yihui Pan, Pengyu Wang, Teng Yang, Meixia Li, Hu Zhou, Kan Ding, Jianhua Gan, Hongbin Ji*, Cai-Guang Yang*, “Selective activator of human ClpP triggers cell cycle arrest to inhibit lung squamous cell carcinoma”, Nat. Commun., 2023, 14:7069.

2.Yue Huang^#, Wenyang Xia^#, Ze Dong, Cai-Guang Yang*. “Chemical Inhibitors Targeting the Oncogenic m⁶A Modifying Proteins”, Acc. Chem. Res., 2023, 56, 3010-3022.

3.Pan Xiao^#, Zongliang Duan^#, Zeyu Liu^#, Liang Chen, Deyan Zhang, Lu Liu, Chen Zhou, Jianhua Gan, Ze Dong*, Cai-Guang Yang*, “Rational Design of RNA Demethylase FTO Inhibitors with Enhanced Antileukemia Drug-like Properties”, J. Med. Chem., 2023, 66, 9731-9752.

4.Bingyan Wei^#, Tao Zhang^#, Pengyu Wang^#, Yihui Pan, Jiahui Li, Weizhong Chen, Min Zhang, Quanjiang Ji, Wenjuan Wu, Lefu Lan, Jianhua Gan, Cai-Guang Yang*. “Anti-infective therapy using a species-specific activator of Staphylococcus aureus ClpP”, Nat. Commun., 2022, 13:6909.

5.Pengyu Wang^#, Tao Zhang^#, Xinjing Wang^#, Hongying Xiao, Huiti Li, Lin-Lin Zhou, Teng Yang, Bingyan Wei, Zeyun Zhu, Lu Zhou, Song Yang, Xiongxiong Lu, Yonghui Zhang, Yue Huang, Jianhua Gan, Cai-Guang Yang*. “Aberrant human ClpP activation disturbs mitochondrial proteome homeostasis to suppress pancreatic ductal adenocarcinoma”, Cell Chem. Biol., 2022, 29, 1396-1408.

6.Zeyu Liu^#, Zongliang Duan^#, Deyan Zhang^#, Pan Xiao, Tao Zhang, Hongjiao Xu, Chuan-Hui Wang, Guo-Wu Rao, Jianhua Gan, Yue Huang*, Cai-Guang Yang*, Ze Dong*, “Structure-activity relationship and antileukemia effects of tricycle benzoic acid FTO inhibitors”. J. Med. Chem., 2022, 65, 10638-10654.

7.Yi Liu^#, Guanghao Liang^#, Hongjiao Xu^#, Wenxin Dong^#, Ze Dong^#, Zhiwei Qiu, Zhihao Zhang, Fangle Li, Yue Huang, Yilin Li, Jun Wu, Shenyi Yin, Yawei Zhang, Peijin Guo, Jun Liu, Jianzhong Jeff Xi, Peng Jiang, Dali Han*, Cai-Guang Yang*, Meng Michelle Xu*. “Tumors exploit FTO-mediated regulation of glycolytic metabolism to evade immune surveillance”. Cell Metabolism, 2021, 33, 1221-1233.

8.Teng Yang^#, Tao Zhang^#, Xiangna Guan, Ze Dong, Lefu Lan, Song Yang*, Cai-Guang Yang*. “Tideglusib and analogs as inhibitors of Staphylococcus aureus SrtA”, J. Med. Chem., 2020, 63, 8442-8457.

9.Ze Dong^#, Zhen Wang^#, Zhong-Qiang Guo, Shouzhe Gong, Cheng Luo, Jiang Liu, Hualiang Jiang, Cai-Guang Yang*, “Structure-activity relationship of SPOP inhibitors against kidney cancer”, J. Med. Chem. 2020, 63, 4849-4866.

10.Yue Huang^#, Rui Su^#, Yue Sheng^#, Lei Dong^#, Ze Dong^#, Hongjiao Xu, Tengfeng Ni, Zijie Scott Zhang, Tao Zhang, Chenying Li, Li Han, Zhenyun Zhu, Fulin Lian, Jiangbo Wei, Qiangqiang Deng, Yungui Wang, Mark Wunderlich, Zhiwei Gao, Guoyu Pan, Dafang Zhong, Hu Zhou, Naixia Zhang, Jianhua Gan, Hualiang Jiang, James C. Mulloy, Zhijian Qian*, Jianjun Chen*, Cai-Guang Yang*. “Small-molecule Targeting of Oncogenic FTO Demethylase in Acute Myeloid Leukemia”, Cancer Cell, 2019, 35, 677-691.

科研项目：

1.国家杰出青年科学基金、重点项目、国际合作项目、重大研究计划项目；

2.国家科技重大专项；国家级创新领军人才；科技部国家重点研发计划；

3.中国科学院“百人”计划、A类先导专项；

4.上海市“优秀学术带头人”计划、“浦江人才”计划。