刘璐

刘璐 博士

助理研究员，国科大杭州高等研究院                                  

浙江省杭州市西湖区象山支路1号 310012  

E-mail: liulusysp@ucas.ac.cn

教育背景：

2017.09–2022.09, 南京师范大学, 化学，博士

2013.09–2017.07, 安庆师范大学, 化学教育, 学士

工作经历：

2025.04 - 至今，国科大杭州高等研究院药物科学与技术学院，助理研究员；

2022.09–2025.03，国科大杭州高等研究院，药物科学与技术学院，博士后；

研究方向：

工作聚焦于靶向RNA去甲基化酶的化学生物学与抗肿瘤机制研究，致力于利用化学小分子工具揭示RNA修饰调控与肿瘤发生中的作用机制，推动相关治疗策略开发。

代表性研究成果：

(1) Lu Liu^#; Yuanlai Qiu^#; Yuying Suo^#; Siyao Tong; Yiqing Wang; Xi Zhang; Liang Chen; Yue Huang; Huchen Zhou; Hu Zhou; Ze Dong; Cai-Guang Yang ; Discovery of a potent PROTAC degrader for RNA demethylase FTO as antileukemic therapy, Acta. Pharm. Sin. B, 2024, 14(12): 5382- 5392

(2) Deyan Zhang^#; Lu Liu^#; Ming Li^#; Xinyi Hu; Xi Zhang; Wenyang Xia; Zhen Wang; Xiaomin Song; Yue Huang; Ze Dong; Cai-Guang Yang ; Development of 3-arylaminothiophenic-2-carboxylic acid derivatives as new FTO inhibitors showing potent antileukemia activities, Eur. J. Med. Chem, 2025, 289: 117444

(3) Lu Liu^#; Yaqiong Kong^#; Liang He; Xiuxiu Wang; Meng‐Meng Wang; Hongjiao Xu; Cai‐Guang Yang; Zhi Su; Jing Zhao; Zong‐Wan Mao; Yue Huang; Hong‐Ke Liu ; A Rhein‐Based Rh( III ) Arene Complex with Anti‐tumor Cell Proliferative Activity Inhibits RNA Demethylase FTO, Chin. J. Chem,2022, 40(10): 1156-1164

(4) Lu Liu; Jun Chen; Meng-Meng Wang; Yuanlei Huang; Yong Qian; Xuling Xue; Zhi Su; Hong-Ke Liu ; The cyclometalated iridium (III) complex based on 9-Anthracenecarboxylic acid as a

lysosomal-targeted anticancer agent, J. Inorg. Biochem, 2022, 235: 111913-111913（

(5) Chao Ge; Lu Liu; Yanqing Wang; Xiaojiao Di; Xiangjie Luo; Hongke Liu; Yong Qian ; Novel 1,8-Naphthalimide Derivatives As Antitumor Agents and Potent Demethylase Inhibitors, ACS Med. Chem. Lett, 2023, 14: 1551-1557

(6) Chao Ge; Ji Li; Lu Liu; Hong-Ke Liu; Yong Qian ; A self-immolated fluorogenic agent triggered by H2S exhibiting potential anti-glioblastoma activity, ANALYST, 2021, 146(11): 3510-3515

(7) Pan Xiao; Zongliang Duan; Zeyu Liu; Liang Chen; Deyan Zhang; Lu Liu; Chen Zhou; JianhuaGan; Ze Dong; Cai-Guang Yang ; Rational Design of RNA Demethylase FTO Inhibitors with Enhanced Antileukemia Drug-Like Properties, Journal of Medicinal Chemistry, 2023, 66(14): 97331- 9752