段彦辉

职称：助理研究员

学历：博士

邮箱：duanyanhui@ucas.ac.cn

通讯地址： 浙江省杭州市西湖区象山支弄1号

教育背景

2012．09--2017．05 同济大学，生物学，博士，导师：谢欣 研究员

2008．09--2012．07 同济大学，生物技术，理学学士

工作经历

2022．05 至今 国科大杭州高等研究院，药物科学与技术学院，助理研究员

2020．11--2022．04 赣南医学院，基础医学院，特聘副教授

2017．11--2020．11 美国韦恩州立大学，生物化学与免疫系，博后

研究方向

1. 髓鞘发生相关药物靶点发现与药物筛选；

2. G蛋白偶联受体（GPCR）信号通路与自身免疫病相关性研究及相关药物研发；

3. 炎症小体相关药物发现及其在疾病中作用研究。

    

代表性论著

1. Yanhui Duan; Jihong Wang; Juan Cai; Nathan Kelley; Yuan He ; The leucine-rich repeat (LRR) domain of NLRP3 is required for NLRP3 inflammasome activation in macrophages, Journal of Biological Chemistry, 2022, 298(12): 102717.

2. Yanhui Duan; Lingzhi Zhang; Diego Angosto-Bazarra; Pelegrin, Pablo; Nunez, Gabriel; Yuan He ; RACK1 Mediates NLRP3 Inflammasome Activation by Promoting NLRP3 Active Conformation and Inflammasome Assembly, Cell Reports, 2020, 33(7): 108405.

3. Yanhui Duan; Nathan Kelley; Yuan He ; Role of the NLRP3 inflammasome in neurodegenerative diseases and therapeutic implications, Neural Regeneration Research, 2020, 15(7): 1249-1250.

4. Ying Shi#; Yan-Hui Duan#(共同一作); Yue-Yang Ji; Zhi-Long Wang; Yan-Ran Wu; Hendra Gunosewoyo; Xiao-Yu Xie; Jian-Zhong Chen,; Fan Yang; Jing Li; Jie Tang; Xin Xie; Li-Fang Yu ; Amidoalkylindoles as Potent and Selective Cannabinoid Type 2 Receptor Agonists with in Vivo Efficacy in a Mouse Model of Multiple Sclerosis, Journal of Medicinal Chemistry, 2017, 60(16): 7067-7083.

5. Changsheng Du#; Yanhui Duan#(共同一作); Wei Wei; Yingying Cai; Hui Chai; Jie Lv; Xiling Du; Jian Zhu; Xin Xie ; Kappa opioid receptor activation alleviates experimental autoimmune encephalomyelitis and promotes oligodendrocyte-mediated remyelination, Nature Communications, 2016, 7(1):11120.

6. Chao Zheng; Dongdong Zhou; Weisong Li; Yanhui Duan; Minwen Xu; Jie Liu; Jingpei Cheng; Youban Xiao; Han Xiao; Tao Gan; Jianmin Liang; Dexian Zheng; Liefeng Wang; Shuyong Zhang; Therapeutic efficacy of a MMAE-based anti-DR5 drug conjugate Oba01 in preclinical models of pancreatic cancer, Cell Death & Disease, 2023, 14(4):295.

7. Nathan Kelley; Devon Jeltema; Yanhui Duan; Yuan He; The NLRP3 Inflammasome: An Overview of Mechanisms of Activation and Regulation, International Journal of Molecular Sciences, 2019, 20(13). pii: ijms20133328.

8. Dongru Su; Min Wang; Chenli Ye; Jiahui Fang; Yanhui Duan; Zhenghong Zhang; Qiuhong Hua; Changjie Shi; Lihong Zhang; Ru Zhang; Xin Xie; One-step generation of mice carrying a conditional allele together with an HA-tag insertion for the delta opioid receptor, Scientific Reports, 2017, 7:44476.