唐峰 博士
研究员，国科大杭州高等研究院
浙江省杭州市西湖区象山支路1号 310012
E-mail: tangfeng2013@simm.ac.cn
教育背景：
2013/09 –至今，中国科学院上海药物研究所，药物化学，博士。
2008/09 – 2012/06，山东大学，生物科学与生物技术，学士。
工作经历：
2023/10–至今，中国科学院上海药物研究所，研究员；
2020/10–2023/09，中国科学院上海药物研究所，副研究员；
2018/07–2020/09，中国科学院上海药物研究所，博士后，合作导师：蒋华良；
研究方向：
基于化学修饰的蛋白质药物研发
（1） 定点抗体-药物偶联物（ADC）研发；
（2） 蛋白质化学修饰与功能拓展；
（3） 蛋白质糖基化修饰与肿瘤干预
（4） 蛋白嵌合体的化学组装策略
代表性研究成果：
1. Lu M#, Zeng Y#, Hang J, Shi W*, Huang W*, Tang F*. Direct Preparation of Site-Specific ADCs with Unpurified Antibodies in Culture Medium. Chembiochem. 2025 Mar 28: e202401082. doi: 10.1002/cbic.202401082.
2. Luo C.#; Ren A.#; Jin Z.#; Zhang J.; Shi W.; Zeng Y.; Liu Z.; Lu M.; Hou Y.; Tang F.*; Huang W.* Design and synthesis of novel site-specific antibody-drug conjugates that target TROP2. Bioorg Med Chem. 2024 Jul 2;110:117828. doi: 10.1016/j.bmc.2024.117828.
3. Zeng Y.#; Shi W.#; Liu Z.; Xu H.; Liu L.; Hang J.; Wang Y.; Lu M.; Zhou W.; Huang W.; Tang F*. C-terminal Modification and Functionalization of Proteins via A Self-cleavage Tag Triggered by A Small Molecule. Nat Commun., 2023 Nov 7;14(1):7169. doi: 10.1038/s41467-023-42977-x.
4. Shi W.#; Zhang J.#; Liu L.#; Li W.#; Liu Z.; Ren A.; Wang J.; Tang C.; Yang Y.; Xu D.; Huang Q.; Wang Y.; Luo C.; Huang W.*; Tang F.* (2022) “Hiding Payload Inside the IgG Fc Cavity Significantly Enhances the Therapeutic Index of Antibody-Drug Conjugates.” J. Med. Chem., 2023, 66, 1, 1011–1026. doi: 10.1021/acs.jmedchem.2c01812.
5. Zeng, Y.; Shi, W.; Dong, Q.;Li, W.; Zhang, J.; Ren, X.; Tang, C.; Liu, B.; Song, Y.; Wu, Y.; Diao, X.; Zhou, H.; Huang, H.; Tang, F.*; Huang, W.* (2022) “A Traceless Site-specific Conjugation on Native Antibodies Enables Efficient One-step Payload Assembly.” Angew. Chem. Int. Ed., 2022, 61, e202117849. doi.org/10.1002/anie.202204132
6. Chen, Y.#; Tang, F.#; Qin, H.#,*; Yue, X.; Nie, Y.; Huang, W.*; Ye, M.* (2022) “Endo-M Mediated Chemoenzymatic Approach Enables Reversible Glycopeptide Labeling for O-GlcNAcylation Analysis.” Angew. Chem. Int. Ed. 2022, 61(23):e202117849. DOI: 10.1002/anie.202117849.
7. Zou, X.; Liu, Z.; Liu, L.; Shi, W.; Li, W.; Guo, Z.*; Tang, F.*; Huang, W.* (2022) “Enhanced transglycosylation activity of an Endo-F3 mutant by ligand-directed localization.” Org. Biomol. Chem. 20, 3086-3095.
8. Shi, W.; Li, W.; Zhang, J.; Li, T.; Song, Y.; Zeng, Y.; Dong, Q.; Lin, Z.; Gong, L.; Fan, S.; Tang, F.*; Huang, W.* (2022) “One-step synthesis of site-specific antibody‒drug conjugates by reprograming IgG glycoengineering with LacNAc-based substrates.” Acta Pharm. Sin. B 12(5), 2417-2428.
9. Long, Y.#; Sun, J.#; Song, T.-Z.#; Liu, T.#; Tang, F.#; Zhang, X.#; Ding, L.#; Miao, Y.; Zhu, W.; Pan, X.; An, Q.; Qin, M.; Tong, X.; Peng, X.; Yu, P.; Zhu, P.; Xu, J.; Zhang, X.; Zhang, Y.; Liu, D.; Chen, B.; Chen, H.; Zhang, L.; Xiao, G.; Zuo, J.; Tang, W.; Zhou, J.; Li, H.; Xu, Z.; Zheng, H.-Y.; Long, X.-Y.; Qin, Q.*; Gan, Y.*; Ren, J.*; Huang, W.*; Zheng, Y.-T.*; Jin, G.*; Gong, L.* (2022) “CoVac501, a self-adjuvanting peptide vaccine conjugated with TLR7 agonists, against SARS-CoV-2 induces protective immunity.” Cell Disc. 8, 9.
10. Shi, W.#; Tang, F.#; Ao, J.; Yu, Q.; Liu, J.; Tang, Y.; Jiang, B.; Ren, X.; Huang, H.; Yang, W.*; Huang, W.* (2020) “Manipulating the click reactivity of dibenzoazacyclooctynes: from azide click component to caged acylation reagent by silver catalysis.” Angew. Chem. Int. Ed. 59(45), 19940-19944. doi.org/10.1002/anie.202009408.
11. Tang, F.#; Zhou, M.#,*; Qin, K.; Shi, W.; Yashinov, A.; Yang, Y.; Yang, L.; Guan, D.; Zhao, L.; Tang, Y.; Chang, Y.; Zhao, L.; Yang, H.; Zhou, H.; Huang, R.; Huang, W.* (2020) “Selective N-glycan editing on living cell surfaces to probe glycoconjugate function.” Nat. Chem. Biol. 16, 766-775. doi.org/10.1038/s41589-020-0551-8.
国科大杭高院药学院