许叶春

个人信息：

许叶春 博士

研究员，国科大杭州高等研究院

浙江省杭州市西湖区象山支路1号 310012

Phone: 021-68077986    

E-mail: ycxu@simm.ac.cn

教育背景：

1995-1999 华东师范大学化学系（理学学士）

1999-2001 华东师范大学化学系（理学硕士）

2001-2004 中国科学院上海药物研究所（理学博士）

工作经历：

2004-2005 中国科学院上海药物研究所（助理研究员）

2005-2009 以色列魏兹曼科学研究所（博士后）

2009-至今 中国科学院上海药物研究所（研究员/课题组长/百人计划）

研究方向：

基于结构的理性药物设计、抗炎和抗病毒候选新药发现研究。

针对病毒感染和免疫炎症相关的重要靶标，采用计算机辅助药物设计与结构药理学等各种技术方法建立分子水平的药物筛选方法，发现新配体并通过基于结构的理性设计高效优化获得先导及候选化合物

代表性研究成果：

1.Xiangrui Jiang^#, Haixia Su^#, Weijuan Shang^#, Feng Zhou^#, Yan Zhang^#, Wenfeng Zhao^#, Qiumeng Zhang, Hang Xie, Lei Jiang, Tianqing Nie, Feipu Yang, Muya Xiong, Xiaoxing Huang, Minjun Li, Ping Chen, Shaoping Peng, Gengfu Xiao, Hualiang Jiang, Renhong Tang*, Leike Zhang*, Jingshan Shen*, Yechun Xu*. Discovery of oral simnotrelvir, an approved SARS-CoV-2 3C-like protease inhibitor for the treatment of COVID-19. Nat. Commun. 2023, 14(1), 6463.

2.Hangchen Hu, Qian Wang, Haixia Su, Qiang Shao, Wenfeng Zhao, Guofeng Chen, Minjun Li*, Yechun Xu*. Identification of cysteine 270 as a novel site for allosteric modulators of SARS-CoV-2 papain-like protease. Angew. Chem. Int. Ed. 2022, 61(52), e202212378.

3.Haixia Su^#, Sheng Yao^#, Wenfeng Zhao^#, Yumin Zhang^#, Jia Liu^#, Qiang Shao^#, Qingxing Wang, Minjun Li, Hang Xie, Weijuan Shang, Changqiang Ke, Lu Feng, Xiangrui Jiang, Jingshan Shen, Gengfu Xiao, Hualiang Jiang, Leike Zhang*, Yang Ye*, Yechun Xu*. Identification of pyrogallol as a warhead in design of covalent inhibitors for the SARS-CoV-2 3CL protease. Nat. Commun. 2021, 12(1), 3623.

4.Wenhao Dai^#, Bing Zhang^#, Xia-Ming Jiang^#, Haixia Su^#, Jian Li, Yao Zhao, Xiong Xie, Zhenming Jin, Jingjing Peng, Fengjiang Liu, Chunpu Li, You Li, Fang Bai, Haofeng Wang, Xi Cheng, Xiaobo Cen, Shulei Hu, Xiuna Yang, Jiang Wang, Xiang Liu, Gengfu Xiao, Hualiang Jiang, Zihe Rao, Lei-Ke Zhang*, Yechun Xu*, Haitao Yang*, Hong Liu*. Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main protease. Science 2020, 368, 1331.

5.Wanchao Yin^#, Chunyou Mao^#, Xiaodong Luan^#, Dan-Dan Shen^#, Qingya Shen^#, Haixia Su^#, Xiaoxi Wang, Fulai Zhou, Wenfeng Zhao, Minqi Gao, Shenghai Chang, Yuan-Chao Xie, Guanghui Tian, He-Wei Jiang, Sheng-Ce Tao, Jingshan Shen, Yi Jiang, Hualiang Jiang, Yechun Xu*, Shuyang Zhang*, Yan Zhang*, H. Eric Xu*. Structural basis for inhibition of the RNA-dependent RNA polymerase from SARS-CoV-2 by remdesivir. Science 2020, 368, 1499.

6.Xianglei Zhang^#, Guangyu Dong^#, Heng Li^#, Wuyan Chen, Jian Li, Chunlan Feng, Zhanni Gu, Fenghua Zhu, Rui Zhang, Minjun Li, Wei Tang*, Hong Liu*, Yechun Xu*. Structure-aided identification and optimization of tetrahydro-isoquinolines as novel PDE4 inhibitors leading to discovery of an effective antipsoriasis agent. J. Med. Chem. 2019, 62(11), 5579.