杨瑞瑞

个人信息：

杨瑞瑞 博士

副研究员，国科大杭州高等研究院

浙江省杭州市西湖区象山支路1号 310012

Phone: 19121702262

E-mail: yangruirui@ucas.ac.cn

教育背景：

2017.09-2022.06 上海科技大学 博士；

2013.09-2017.06 北京中医药大学 学士；

工作经历：

2025.03至今 国科大杭州高等研究院 药物科学与技术学院 副研究员；

2024.10-2025.02 中国科学院上海药物研究所 副研究员；

2022.07-2024.09 中国科学院上海药物研究所 博士后；

研究方向：

药物设计与药物化学生物学

（1）针对免疫、肿瘤领域的重要靶标发现先导化合物及作用机制研究；

（2）老药新靶标、新机制的发现

代表性研究成果：

1. Ruirui Yang^#, Bei Wang^#, Zhaomin Su, Ying Song, Yingying Zhang, Yadan Liu, Yinghui Zhang, Xi Yang, Changyu He, Feisheng Zhong, Zunyun Fu, Yiluan Ding, Naixia Zhang, Rui Li, Shuqing Chu, Chuanhai Xu, Jian Sun, Wei Geng*, Sulin Zhang* and Mingyue Zheng*, Methotrexate exerts antitumor immune activity and improves the clinical efficacy of immunotherapy in patients with solid tumors, Science Translational Medicine，Accepted (^#共同第一作者).

2. Siyu Pei^#, Xiuyu Deng^#, Ruirui Yang^#, Hui Wang^#, Jian-Hong Shi^#, Xueqing Wang, Jia Huang, Yu Tian, Rongjing Wang, Sulin Zhang, Hui Hou, Jing Xu, Qingcheng Zhu, Huan Huang, Jialing Ye, Cong-Yi Wang, Wei Lu, Qingquan Luo*, Zhi-Yu Ni*, Mingyue Zheng*, Yichuan Xiao*. Age-related decline in CD8+ tissue resident memory T cells compromises antitumor immunity. Nature Aging. 2024 Dec;4(12):1828-1844.

3. Shiping Zhan^#, Yingying Zhang^#, Tian Cao^#, Ruirui Yang^#, Qiang Wang, Lin Huang, Rongrong Cui, Jie Yu, Haifang Meng, Yitian Wang, Sulin Zhang*, Mingyue Zheng*, Xiaowei Wu*. Discovery of Imidazo[1,2-a]pyrazine Derivatives as Potent ENPP1 Inhibitors. Journal of Medicinal Chemistry. 2024 Oct 24;67(20):18317-18333.

4. Yinghui Zhang^#, Yadan Liu^#, Bing Jiang^#, Lifan Chen, Jie Hu, Buying Niu, Jie Chang, Zisheng Fan, Jingyi Zhou, Yajie Wang, Dan Teng, Ning Ma, Xiaofeng Wang, Ruirui Yang*, Mingyue Zheng*, Sulin Zhang*. Targeting STING oligomerization with licochalcone D ameliorates STING-driven inflammatory diseases. Science China. Life sciences. 2024 Dec;67(12):2664-2677.

5. Lifan Chen^#, Zisheng Fan^#, Jie Chang^#, Ruirui Yang^#, Hui Hou^#, Hao Guo, Yinghui Zhang, Tianbiao Yang, Chenmao Zhou, Qibang Sui, Zhengyang Chen, Chen Zheng, Xinyue Hao, Keke Zhang, Rongrong Cui, Zehong Zhang, Hudson C. Ma, Yiluan Ding, Naixia Zhang, Xiaojie Lu, Xiaomin Luo, Hualiang Jiang, Sulin Zhang^*, Mingyue Zheng^*, Sequence-based drug design as a concept in computational drug design, Nature Communications, 2023, 14, 4217.

6. Jia Song^#, Ruirui Yang^#, Jie Chang^#, Yadan Liu^#, Chenghao Lu, Lifan Chen, Hao Guo, Yinghui Zhang, Zisheng Fan, Jingyi Zhou, Guizhen Zhou, Keke Zhang, Xiaomin Luo, Kaixian Chen, Hualiang Jiang, Sulin Zhang, Mingyue Zheng, Discovery and characterization of a novel cGAS covalent inhibitor for the treatment of inflammatory bowel disease, Acta Pharmacologica Sinica, 2023, 44(4): 791-800.

7. Jing-yi Zhou^#, Ruirui Yang^#, Jie Chang, Jia Song, Zisheng Fan, Yinghui Zhang, Chenghao Lu, Hualiang Jiang*, Sulin Zhang*, Mingyue Zheng*. Discovery and identification of a novel small molecule BCL-2 inhibitor that binds to the BH4 domain, Acta Pharmacologica Sinica, 2023, 44(2): 475-485.

8. Feisheng Zhong^#, Xiaolong Wu^#, Ruirui Yang^#, Xutong Li, Dingyan Wang, Zunyun Fu, Xiaohong Liu, XiaoZhe Wan, Tianbiao Yang, Zisheng Fan, Yinghui Zhang, Xiaomin Luo, Kaixian Chen, Sulin Zhang*, Hualiang Jiang*, and Mingyue Zheng*, Drug target inference by mining transcriptional data using a novel graph convolutional network framework, Protein & Cell, 2022, 13(4):281-301.

9. Jie Chang^#, Ruirui Yang^#, Lifan Chen^#, Zisheng Fan, Jingyi Zhou, Hao Guo, Yinghui Zhang, Yadan Liu, Guizhen Zhou, Keke Zhang, Kaixian Chen, Hualiang Jiang*, Mingyue Zheng*, Sulin Zhang*. Discovery of ARF1-targeting inhibitor demethylzeylasteral as a potential agent against breast cancer, Acta Pharmaceutica Sinica B, 2022, 12(5): 2619-2622.

10. Xiaoqin Tan^#, Chunpu Li^#, Ruirui Yang^#, Sen Zhao, Fei Li, Xutong Li, Lifan Chen, Xiaozhe Wan, Xiaohong Liu, Tianbiao Yang, Xiaochu Tong, Tingyang Xu, Rongrong Cui, Hualiang Jiang, Sulin Zhang*, Hong Liu*, and Mingyue Zheng*, Discovery of Pyrazolo[3,4-d]pyridazinone Derivatives as Selective DDR1 Inhibitors via Deep Learning Based Design, Synthesis, and Biological Evaluation, Journal of Medicinal Chemistry, 2022, 65(1): 103-119.

11. Hui Hou^#, Ruirui Yang^#, Xiaohong Liu, Xiaolong Wu, Sulin Zhang*, Kaixian Chen*, Mingyue Zheng*. Discovery of triazoloquinoxaline as novel STING agonists via structure-based virtual screening. Bioorganic Chemistry, 2020;100:103958.

科研项目：

1. 国家自然科学基金青年项目，2024.01至2026.12，项目负责人，在研

2. 上海市“超级博士后”激励计划项目，2022.07至2024.07，项目负责人，结题