程曦

个人信息：

程曦 博士

研究员，国科大杭州高等研究院

浙江省杭州市西湖区象山支路1号 310012

Phone: 0571-86080393

E-mail: xicheng@ucas.ac.cn

教育背景：

2010-08 至 2015-05, 堪萨斯大学, 计算生物, 博士，导师Wonpil Im

2006-09 至 2010-06, 华中科技大学, 生物信息, 学士

工作经历：

2021-10 至 今,中国科学院上海药物研究所, 研究员

2017-10 至 2021-09,中国科学院上海药物研究所, 副研究员

2017-10 至 2021-09,中国科学院上海药物研究所, 博士后，导师蒋华良

研究方向：

主要从事理论计算驱动的药物科学基础研究和新药发现，利用模拟计算方法揭示多种重要膜蛋白的分子调控机制，应用计算机辅助药物设计方法获得多个全新先导化合物，发展了一系列分子动力学模拟计算方法和新工具，获得国际同行和工业界广泛应用。发表SCI论文50余篇，他引5000多次；在Nature、JACS和PNAS等期刊发表（共同）第一或通讯作者论文20余篇。

代表性研究成果：

1. 1.L Zhao; F Wei; X He; A Dai; D Yang; H Jiang; L Wen*; X Cheng*; Identification of a carbohydrate recognition motif of purinergic receptors, eLife, 2023, 12: e85449

2. 2.B Xia^#, *; J Fang^#; S Ma^#; M Ma^#; G Yao; T Li; X Cheng*; L Wen*; Z Gao*; Mapping the acetylamino and carboxyl groups on glycans by engineered α-hemolysin nanopores, JACS, 2023, 145:18812

3. 3.R Li; L Chen; X He; D Cao; Z Zhang; H Jiang*; K Chen*; X Cheng*; Loops mediate agonist-induced activation of the stimulator of interferon genes protein, J Chem Inf Model, 2023, 65(23):7373

4. 4.X He; C You; H Jiang; Y Jiang*; HE Xu*; X Cheng*; AlphaFold2 versus experimental structures: evaluation on G protein-coupled receptors, Acta Pharm Sin, 2022, 44(1): 1

5. 5.X He; J Duan; Y Ji; L Zhao; H Jiang; Y Jiang*; HE Xu*; X Cheng*; Hinge region mediates signal transmission of luteinizing hormone and chorionic gonadotropin receptor, Comput Struct Biotechnol J, 2022, 20: 6503

6. 6.Z Cong^#; F Zhou^#; C Zhang^#; X Zou^#; H Zhang; Y Wang; Q Zhou; X Cai; Q Liu; J Li; L Shao; C Mao; X Wang; J Wu; T Xia; L Zhao; H Jiang; Y Zhang; HE Xu; X Cheng*; D Yang*; M Wang*; Constitutive signal bias mediated by the human GHRHR splice variant 1, PNAS, 2021, 118(40): e2106606118

7. 7.P Xu^#; S Huang^#; C Mao^#; B Krumm^#; X Zhou; Y Tan; X Huang; Y Liu; D Shen; Y Jiang; X Yu; H Jiang; K Melcher; B Roth*; X Cheng*; Y Zhang*; HE Xu*; Structures of the human dopamine D3 receptor-Gi complexes, Mol Cell, 2021, 81(6): 1147

8. 8.J Duan^#; P Xu^#; X Cheng^#; C Mao^#; T Croll; X He; J Shi; X Luan; W Yin; E You; Q Liu; S Zhang; H Jiang; Y Zhang; Y Jiang; HE Xu; Structures of full-length glycoprotein hormone receptor signalling complexes, Nature, 2021, 598(7882): 688

9. 9.P Xu^#; S Huang^#; H Zhang^#; C Mao^#; X Zhou^#; X Cheng^#; Í Simon; D Shen; H Yen; C Robinson; K Harpsøe; B Svensson; J Guo; H Jiang; D Gloriam; K Melcher; Y Jiang*; Y Zhang*; H Xu*; Structural insights into the lipid and ligand regulation of serotonin receptors, Nature, 2021, 592(7854): 469-473

10. 10.X Wang^#; X Cheng^#; L Zhao^#; Y Wang; C Ye; X Zou; A Dai; Z Cong; J Chen; Q Zhou; T Xia; H Jiang; EH Xu*; D Yang*; M Wang*; Molecular insights into differentiated ligand recognition of the human parathyroid hormone receptor 2, PNAS, 2021, 118(32): e2101279118