Recently, the International Carbohydrate Organization announced that research fellowYu Biao, Executive Dean of the School of Chemistry and Materials Science, won the 2022 Roy L Whistler International Award in Carbohydrate Chemistry,the highest international award in carbohydrate chemistry. Moreover, he becamethe first Chinese scholar to win the award.
(https://ico.chemistry.unimelb.edu.au/news-events/, if you want to learn more about it, please click "Read More" at the end of the article)
In 1984, the International Carbohydrate Organization established the $10,000 award to honor Professor Roy L Whistler and recognize scientists who have contributed greatly to the field of carbohydrate chemistry and biochemistry and are expected to continue to make significant contributions.
Research fellow Yu Biao has long focused on the chemical synthesis and biological activity of carbohydrates. The glycosidation method invented by his laboratory with PTFAI as the donor is a general method for the synthesis of complex glycans and glycoconjugates, which has been applied in 90 laboratories around the world and is known as one of the three milestones in catalyzing glycosidation. The Gold(I)-Catalyzed Glycosylation with Glycosyl o-Alkynylbenzoates as Donors has realized the construction of special glycoside bonds that cannot be achieved by other methods. It is called Yu Glycosidation. His laboratory has first completed the full synthesis of a complex range of natural carbohydrate conjugates, including 63 steps for landomycin A and 79 steps for periploside A with special orthoester glycoside bonds. Recently, his research group has also finished the chemical synthesis of glycans up to a 128-mer relevant to the O-antigen of Bacteroides vulgatus, the longest chemically synthesized glycans to date. His laboratory has also carried out extensive and in-depth cooperative research on the structure-activity relationship and mechanism of action of glycans and glycoside molecules, elucidating the mechanism of Hoodia saponins controlling appetite and treating diabetes by activating the GPR119 receptor, and developing glycosylated tripterygium wilfordii lactone as a leader compound of antineoplastic drugs.
Congratulations to fellow researcher Yu Biao!
Source | School of Chemistry and Materials Science
Scan the QR code and follow the official account of "HIAS-UCAS"!HIAS-UCAS
WeChat ID: UCAS-HIAS
Official website丨http://hias.ucas.ac.cn/
Email: hangzhou@ucas.ac.cn
Published in Zhejiang and revised on August 12, 2021.
Read More
Scan with WeChat
Follow us
