Recently, the finals of the 7th China International College Students' "Internet Plus" Innovation and Entrepreneurship Competition came to an end at Nanchang University. The HIAS team's MicroIDx: A Smartphone-based Molecular Diagnostic IoT-POCT Device guided by Song Jinzhao, a teacher from the School of Molecular Medicine, Hangzhou Institute for Advanced Study(HIAS) won the bronze award.
The"micro-detection" system designed by the project is the first medical IoT device in the world to use POCT as the perception layer. The micro-detection system uses the RAMPisothermal amplification of nucleic acids and the PASEA POCT gene mutation detection method independently developed by the team, with strong sensitivity and specificity in nucleic acid detection and multiple detection capabilities.The system can realize a complete testing process from sampling, transferring samples to chips, inserting chips into the instrument, automatic reading of patient information by electronic equipment, and nucleic acid testing to resulting data synchronization within 30 minutes. It has greatly improved testing efficiency.
Over 9.56 million participants with more than 2.28 million projects from 4,347 institutions from 121 countries and regions signed up for the competition. The international item includes 1,263 schools, 5,531 projects, and 15,611 participants from 117 countries and regions abroad, basically including Harvard University, Massachusetts Institute of Technology, Oxford University, Cambridge University, and other top 100 universities in the world.
Song Jinzhao is a distinguished research fellow of the Institute of Basic Medicine and Cancer, the Chinese Academy of Sciences, and a double-employed professor from HIAS. Since 2013, he has been engaged in postdoctoral research at the UCLA Medical School and Penn Engineering. Before returning to China, he worked as a research assistant professor at the University of Pennsylvania. As an independent PI and co-PI, he successfully received funding from two scientific research projects, including NIH K01 and NIH R21, and an entrepreneurial incubation fund, with a total amount of USD 1.3 million. He also won the NIH Mentored Research Scientist Development Award and the "Young Scientist Award for Precision Medicine" by the American Association for Clinical Chemistry.
He has long been committed to the research of molecular diagnostic methods, reagents, and testing instruments, and has developed a series of new principles, methods, and devices for molecular diagnostics through interdisciplinary research in analytical chemistry, molecular biology, and engineering technology (mechanics, electronics, computer science, etc.). 1) For the first time, Argonaute proteins (pAgo) are introduced into molecular diagnosis as programmable endonucleases, and a highly sensitive enrichment and detection method for rarely mutated genes is set up. The method is successfully used in liquid biopsy of pancreatic cancer and enriched the "tool enzyme box" for molecular diagnosis.2) A number of instant molecular diagnosis systems are established, and the instant and rapid nucleic acid detection methods for Zika and COVID-19 are used for the detection of these two viruses, and their industrialization is being promoted.
Song Jinzhao's research group has long recruited excellent postdoctors and research assistants. If you are interested in it, please send your resume to songjinzhao@iccas.ac.cn, with the email subject of "postdoctor/research assistant + name + research direction/major", and indicate the estimated entry time in the email.
Source | Zhou Yan, Science and Technology Innovation Center
Typesetter | Yu Xuan
Editor | Yao Tingji
Executive Editor | Yan Hao
