教授(正高)

张爱茜

发布者:环境学院  时间:2021-05-21  浏览:

姓名:张爱茜

性别:

职称:教授

邮箱:aqzhang@rcees.ac.cn

研究方向:理论环境化学

简历:

1998年南京大学环境科学与工程系获环境化学方向博士学位,1998-2009南京大学环境学院工作,现为中国科学院生态环境研究中心研究员,博士生导师。研究方向为理论环境化学与污染物构效关系,主要从事有机污染物环境化学过程的理论模拟、构效关系及其在生态风险评价中的应用研究。利用生物信息学、计算化学和定量结构-活性相关技术,确定污染物环境形态,筛选生态毒性并建立其与生物靶点相互作用模型,分析毒性作用的分子机制,发展定量预测模型。近几年,在体内靶点选择及分子毒理、非单调剂量-效应关系形成机制等方面开展研究。

社会任职:

2008年 中国化学会环境化学专业委员会第二届委员

2008年 中国环境科学学会环境化学分会委员

2016年 中国毒理学会计算毒理专业委员会副主任委员

承担科研项目:

  1. 国家自然科学基金重大研究计划项目,效应导向的典型共存污染对大气细颗粒物环境持久性自由基毒性影响的化学机制研究,2018.01-2021.12,在研,主持

  2. 中国科学院先导专项B课题,面向风险筛查的高通量毒性评价与应用模型,2014.7-2019.6,在研,主持

  3. 国家自然科学基金项目,典型羟基多溴联苯醚拟/抗激素效应的H12定位选择机制及构效关系研究,2011.1-2013.12,结题,主持

  4. 国家自然科学基金项目,典型五聚体门控离子通道介导的PCBsPBDEs神经毒性机制的理论研究,2012.1-2015.12,结题,主持

  5. 国家自然科学基金项目,全氟化合物通过组蛋白乙酰化酶抑制干扰雌激素受体介导信号通路的理论研究,2013.1-2016.12,结题,主持

获奖及荣誉:

  1. 2013年,中国科学院杰出科技成就奖(主要完成人)。

  2. 2014年,第11届国际PTS研讨会青年科学家奖。

  3. 2011年,中国毒理学会全国优秀青年科技奖。

代表性论文:

  1. Gao, K.; Zhuang, T.; Liu, X.; Fu, J.; Zhang, J.; Fu, J.; Wang, L.; Zhang, A.; Liang, Y.; Song, M.; Jiang, G., Prenatal Exposure to Per- and Polyfluoroalkyl Substances (PFASs) and Association between the Placental Transfer Efficiencies and Dissociation Constant of Serum Proteins-PFAS Complexes. Environ Sci Technol 2019. https://doi.org/10.1021/acs.est.9b00715.

  2. Li, X.; Gao, K.; Dong, S.; Liu, X.; Fu, K.; Wang, P.; Zhang, A.; Su, X.; Fu, J., Length-specific occurrence and profile of perfluoroalkyl acids (PFAAs) in animal protein feeds. J Hazard Mater 2019, 373, 224-231.

  3. Cao, H.; Wang, L.; Liang, Y.; Li, Z.; Feng, H.; Sun, Y.; Zhang, A.; Fu, J., Protonation state effects of estrogen receptor alpha on the recognition mechanisms by perfluorooctanoic acid and perfluorooctane sulfonate: A computational study. Ecotoxicol Environ Saf 2019, 171, 647-656.

  4. Gao, K.; Fu, J.; Xue, Q.; Fu, J.; Fu, K.; Zhang, A.; Jiang, G., Direct determination of free state low molecular weight compounds in serum by online TurboFlow SPE HPLC-MS/MS and its application. Talanta 2019, 194, 960-968.

  5. Pan, W.; Chang, J.; Liu, X.; Xue, Q.; Fu, J.; Zhang, A., Interfacial formation of environmentally persistent free radicals-A theoretical investigation on pentachlorophenol activation on montmorillonite in PM2.5. Ecotoxicol Environ Saf 2019, 169, 623-630.

  6. Liu, X.; Zhang, H.; Pan, W.; Xue, Q.; Fu, J.; Liu, G.; Zheng, M.; Zhang, A., A novel computational solution to the health risk assessment of air pollution via joint toxicity prediction: A case study on selected PAH binary mixtures in particulate matters. Ecotoxicol Environ Saf 2019, 170, 427-435.

  7. Xue, Q.; Liu, X.; Liu, X. C.; Pan, W. X.; Fu, J. J.; Zhang, A. Q., The Effect of Structural Diversity on Ligand Specificity and Resulting Signaling Differences of Estrogen Receptor alpha. Chem Res Toxicol 2019. DOI: 10.1021/acs.chemrestox.8b00338

  8. Feng, H.; Zhang, H.; Cao, H.; Sun, Y.; Zhang, A.; Fu, J., Application of a Novel Coarse-Grained Soil Organic Matter Model in the Environment. Environ Sci Technol 2018, 52 (24), 14228-14234.

  9. Fu, J.; Zhang, H.; Zhang, A.; Jiang, G., E-waste Recycling in China: A Challenging Field. Environ Sci Technol 2018, 52 (12), 6727-6728.

  10. Li, Y.; Gao, K.; Duo, B.; Zhang, G.; Cong, Z.; Gao, Y.; Fu, J.; Zhang, A.; Jiang, G., Analysis of a broad range of perfluoroalkyl acids in accipiter feathers: method optimization and their occurrence in Nam Co Basin, Tibetan Plateau. Environ Geochem Health 2018, 40 (5), 1877-1886.

  11. Yu, X.; Chang, J.; Liu, X.; Pan, W.; Zhang, A., Theoretical study on the formation mechanism of polychlorinated dibenzothiophenes/thianthrenes from 2-chlorothiophenol molecules. J Environ Sci (China) 2018, 66, 318-327.

  12. Liu, Y.; Fu, J.; Pan, W.; Xue, Q.; Liu, X.; Zhang, A., Inhibition of thrombin by functionalized C60 nanoparticles revealed via in vitro assays and in silico studies. J Environ Sci (China) 2018, 63, 285-295.

  13. Liu, Y.; Yan, B.; Winkler, D. A.; Fu, J.; Zhang, A., Competitive Inhibition Mechanism of Acetylcholinesterase without Catalytic Active Site Interaction: Study on Functionalized C60 Nanoparticles via in Vitro and in Silico Assays. ACS Appl Mater Interfaces 2017, 9 (22), 18626-18638.

  14. Pan, W.; Fu, J.; Zhang, A., Theoretical study on the formation mechanism of pre-intermediates for PXDD/Fs from 2-Bromophenol and 2-Chlorophenol precursors via radical/molecule reactions. Environ Pollut 2017, 225, 439-449.

  15. Li, H.; Fu, J.; Pan, W.; Wang, P.; Li, Y.; Zhang, Q.; Wang, Y.; Zhang, A.; Liang, Y.; Jiang, G., Environmental behaviour of short-chain chlorinated paraffins in aquatic and terrestrial ecosystems of Ny-Alesund and London Island, Svalbard, in the Arctic. Sci Total Environ 2017, 590-591, 163-170.

  16. Li, H.; Fu, J.; Zhang, A.; Zhang, Q.; Wang, Y., Occurrence, bioaccumulation and long-range transport of short-chain chlorinated paraffins on the Fildes Peninsula at King George Island, Antarctica. Environ Int 2016, 94, 408-414.

  17. Gao, K.; Gao, Y.; Li, Y.; Fu, J.; Zhang, A., A rapid and fully automatic method for the accurate determination of a wide carbon-chain range of per- and polyfluoroalkyl substances (C4-C18) in human serum. J Chromatogr A 2016, 1471, 1-10.

  18. Gao, Y.; Fu, J.; Cao, H.; Wang, Y.; Zhang, A.; Liang, Y.; Wang, T.; Zhao, C.; Jiang, G., Differential accumulation and elimination behavior of perfluoroalkyl Acid isomers in occupational workers in a manufactory in China. Environ Sci Technol 2015, 49 (11), 6953-62.

  19. Li, J.; Ma, D.; Lin, Y.; Fu, J.; Zhang, A., An exploration of the estrogen receptor transcription activity of capsaicin analogues via an integrated approach based on in silico prediction and in vitro assays. Toxicol Lett 2014, 227 (3), 179-88.

  20. Fu, J.; Zhang, A.; Wang, T.; Qu, G.; Shao, J.; Yuan, B.; Wang, Y.; Jiang, G., Influence of e-waste dismantling and its regulations: temporal trend, spatial distribution of heavy metals in rice grains, and its potential health risk. Environ Sci Technol 2013, 47 (13), 7437-45.

  21. Fu, J.; Wang, T.; Wang, P.; Qu, G.; Wang, Y.; Zhang, Q.; Zhang, A.; Jiang, G., Temporal trends (2005-2009) of PCDD/Fs, PCBs, PBDEs in rice hulls from an e-waste dismantling area after stricter environmental regulations. Chemosphere 2012, 88 (3), 330-5.

  22. Mu, Y.; Peng, S.; Zhang, A.; Wang, L., Role of pocket flexibility in the modulation of estrogen receptor alpha by key residue arginine 394. Environ Toxicol Chem 2011, 30 (2), 330-6.

  23. Fu, J. J.; Wang, Y. W.; Zhou, L. J.; Zhang, A. Q.; Jiang, G. B., Pollution Status and Perspectives of Persistent Toxic Substances in E-Waste Dismantling Area in China. Prog Chem 2011, 23 (8), 1755-1768.

  24. Qiu, S.; Tan, X.; Wu, K.; Zhang, A.; Han, S.; Wang, L., Experimental and theoretical study on molecular structure and FT-IR, Raman, NMR spectra of 4,4'-dibromodiphenyl ether. Spectrochim Acta A Mol Biomol Spectrosc 2010, 76 (5), 429-34.

  25. Qiu, S.; Liu, L.; Jin, X.; Zhang, A.; Wu, K.; Wang, L., Vibrational spectroscopic investigation and DFT studies on 2,2',4,4'-tetrabromodiphenyl ether. Spectrochim Acta A Mol Biomol Spectrosc 2010, 77 (3), 572-8.

  26. Mu, Y. S.; Liu, L.; Zhang, A. Q.; Lin, Y.; Wang, L. S., QSAR Study on Chiral Chemicals and Further Application in Environmental Science. Prog Chem 2009, 21 (10), 2235-2241.

  27. Gao, C. A.; Zhang, A. Q.; Lin, Y.; Yin, D. Q.; Wang, L. S., Quantitative structure-activity relationships of selected phenols with non-monotonic dose-response curves. Chinese Sci Bull 2009, 54 (10), 1786-1796.

 

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