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何滨

发布者：环境学院  时间：2021-05-21  浏览：

姓名：何滨

http://et.rcees.ac.cn/rcdw/yjry/yjy/201906/W020190606584687045459.jpg

性别：女

职称：教授

邮箱：bhe@rcees.ac.cn

研究方向：金属与生物分子的作用机制研究

教育经历

1995/09-2000/07，中国科学院生态环境研究中心，环境化学与生态毒理学国家重点实验室，环境科学，博士 导师：江桂斌院士、徐晓白院士

1986/09-1990/07，北京化工大学，工业分析，学士

工作经历

2013/12-至今，中国科学院生态环境研究中心，环境化学与生态毒理学国家重点实验室，研究员，博士生导师

2001/01-2013/12，中国科学院生态环境研究中心，环境化学与生态毒理学国家重点实验室，副研究员，硕士生导师

2011/04-2011/08，香港大学，访问学者

2003/03-2004/03，加拿大埃德蒙顿大学，博士后

1990/07-2000/12，中国科学院生态环境研究中心，环境化学与生态毒理学国家重点实验室，助理研究员

承担科研项目：

  1. 国家自然科学基金面上项目，21777179，汞的微生物甲基化分子机制研究，2018/01-2021/12，直接经费64万元，在研，主持。

  2. 国家自然科学基金面上项目，21577153，柱状凝胶色谱与质谱联用技术研究及其在金属蛋白分析中的应用，2016.01-201-/12，直接经费72万元，在研，主持。

  3. 国家自然科学基金面上项目，21277151，二维色谱—质谱技术在金属化合物诱导蛋白表达差异研究中的应用，2013/01-2016/12，经费82万元，结题，主持。

  4. 国家自然科学基金面上项目，21075130，典型中药中汞、砷和硒的形态及其生物有效性研究，2011/01-2013/12，经费38万元，结题，主持。

  5. 国家自然科学基金面上项目，20677069，高效液相色谱与氢化物发生原子荧光在线联用用于多种硒化合物形态分析的方法研究，2007/01-2009/12，经费28万元，结题，主持。

  6. 国家自然科学基金面上项目，20577057，稀有鮈鲫鱼类组织和细胞中外源性有毒金属化合物的金属组学研究，2006/01-2008/12，经费26万元，结题，主持。

  7. 国家自然科学基金青年科学基金项目，20205008，液相色谱与原子荧光在线联用及在形态分析中的应用，2003/01-2005/12，经费22万元，结题，主持。

  8. 国家973项目， 2013CB430004-03，我国汞污染特征、环境过程及减排技术原理，课题四专题3环渤海区域汞的污染特征及迁移规律，2013/01-2017/08，92.25万，结题，专题负责人。

  9. 国家自然科学基金重点项目，20937002，我国环境汞污染的来源、化学特征及转化机制研究，课题3：环境中汞的光化学甲基化过程及机理研究，2010/1-2013/12，课题经费70万元，结题，课题3负责人。

  10. 国家科技攻关计划课题国家高技术研究发展计划项目，SQ2008AA06XK1475931，优控污染物监测技术研究，课题：优控污染物监测新技术与质控产品研制，子课题：有机金属化合物标准参考物质的研制，2008/09-2011/12，子课题经费：70万元，结题，子课题负责人。

  11. 国家科技支撑计划项目，2006BAK03A14，科学仪器设备研制与开发，课题2之任务二：监测检测专用仪器产业化示范—现场检测原子吸收光谱仪及色谱—原子荧光联用仪，2007/01-2010/03，任务经费：36万元，结题，任务二负责人。

  12. 中国科学院知识创新工程重要方向项目，KZCX3-SW-431，课题1：生活饮用水和再生水安全性评价方法和指标体系研究，2004/01-2006/12，课题经费：50万元，结题，课题1负责人。

  13. 国家科技攻关计划课题，2002BA906A28，，痕量污染物权威检测技术及计量基标准的研究，专题：重要技术标准研究，2002/10- 2005/06，专题经费：45万元，结题，专题负责人.

  14. 国家重点基础研究发展计划（973计划），2003CB415001，持久性有机污染物的环境安全、演变趋势与控制原理, 2003/11-2008/12，结题，参加.

  15. 国家重点基础研究发展计划（973计划），2005CB422206，我国酸雨沉降机制、输送态势与调控原理，2005/10-2010/12，负责经费：30万元，结题, 参加。

  16. 国科学院国际合作重点项目（中挪合作项目），GJHZ05，大气污染物沉降对我国土壤酸化和重金属活化的影响研究，2007/05-2008/04，负责经费：20万元，结题，参加 

获奖及荣誉：

  1. 中国分析测试协会科学技术奖特等奖（2014年，排名第4）

  2. 中国分析测试学会科学技术一等奖（2005，排名第4）

  3. 中国分析测试学会科学技术一等奖（2001，排名第4）

  4. 中国科学院院长奖学金优秀学生奖（2000年）

  5. 宝钢教育基金优秀学生奖（2000年）

  6. 中国科学院刘永龄奖学金奖（1998）

  7. 中国科学院自然科学奖二等奖（1998，排名第6）

代表性论文：

  1. Lihong Liu, Yu Zhang, Zhaojun Yun, Bin He*, Qinghua Zhang, Ligang Hu, Guibin Jiang. Speciation and bioaccessibility of arsenic in traditional Chinese medicines and assessment of its potential health risk. Sci. Total Environ., 2018, 619-620, 1088-1097.

  2. Yiling Li, Bin He*, Ligang Hu*, Xiu Huang, Zhaojun Yun, Runzeng Liu, Qunfang Zhou, Guibin Jiang. Characterization of mercury-binding proteins in human neuroblastoma SK-N-SH cells with immobilized metal affinity chromatography. Talanta, 2018, 178, 811-817.

  3. Xueting Yan, Bin He*, Lihong Liu, Guangbo Qu, Jianbo Shi, Chunyang Liao, Ligang Hu*, Guibin Jiang. Prganotin exposure stimulates steroidogenesis in H295R Cell via cAMP pathway. Ecotox. Environ. Safe., 2018, 156, 148-153.

  4. Xueting Yan, Bin He*, Lihong Liu, Guangbo Qu, Jianbo Shi, Ligang Hu* and Guibin Jiang. Antibacterial mechanism of silver nanoparticles in Pseudomonas aeruginosa: proteomics approach. Metallomics, 2018, 10, 557-564.

  5. Xueting Yan, Bin He*, Ligang Hu*, Jiejun Gao, Shuai Chen, Guibin Jiang. Insight into the endocrine disrupting effect and cell response to butyltin compounds in H295R cell: Evaluated with proteomics and bioinformatics analysis. Sci. Total Environ., 2018, 628-629, 1489-1496.

  6. Xueting Yan, Bin He*, Dingyi Wang, Ligang Hu*, Lihong Liu, Chunyang Liao, Guibin Jiang. Two-dimensional (weak anion exchange chromatography-gel electrophoresie) separations coupling to inductively coupled plasma mass spectrometry strategy for analysis of metalloproteins. Talanta, 2018, 184, 404-410.

  7. Chenbin Zheng, Ligang Hu, Xiandeng Hou, Bin He*, and Guibin Jiang. Headspace Solid-Phase Microextraction Coupled to Miniaturized Microplasma Optical Emission Spectrometry for Detection of Mercury and Lead. Anal. Chem., 2018, 90, 3683-3691.

  8. Lihong Liu, Yu Zhang, Zhaojun Yun, Bin He*, Guibin Jiang. Estimation of bioaccessibility and potential human health risk of mercury in Chinese patent medicines. J. Environ. Sci. (China), 2016, 39, 37-44.

  9. Lihong Liu, Zhaojun Yun, Bin He*, and Guibin Jiang. Efficient interface for online coupling of capillary electrophoresis with inductively coupled plasma-mass spectrometry and its application in simultaneous speciation analysis of arsenic and selenium. Anal. Chem., 2014, 86, 8167-8175

  10. Liu, L; He, B.*, Yun, Z.; Sun, J.; Jiang, G.. Speciation analysis of arsenic compounds by capillary electrophoresis on-line coupled with inductively coupled plasma mass spectrometry using a novel interface. J. Chromatogr. A, 2013, 1304, 227-233.

  11. Yun, Z.; Li, L.; Liu, L.; He, B.*; Zhao, X.; Jiang, G.. Characterization of mercury-containing protein in human plasma. Metallomics, 2013, 5, 821-827.

  12. Yun, Z.; He, B.*; Wang, Z.; Wang, T.; Jiang, G.. Evaluation of different extraction procedures for determination of organic mercury species in petroleum by high performance liquid chromatography coupled with cold vapor atomic fluorescence spectrometry. Talanta, 2013, 106, 60-65.

  13. Zhang, K.; He, B.*; Cui, Z.; Cao, D.; Jiang, G.. A candidate reference material 'Mya arenaria' for the monitoring of butyltin compounds in mollusks in the marine environment. Anal. Methods, 2013, 5, 4487-4493.

  14. He, B.; Yun, Z.; Shi, J.; Jiang, G*.. Research progress of heavy metal pollution in China: Sources, analytical methods, status, and toxicity. Chin. Sci. Bull., 2013, 58, 134-140.

  15. Sun, J.; He, B.*; Liu, Q.; Ruan, T.; Jiang, G.. Characterization of interactions between organotin compounds and human serum albumin by capillary electrophoresis coupled with inductively coupled plasma mass spectrometry. Talanta, 2012, 93, 239-244.

  16. Chen, B.; Wang, T.; Yin, Y.; He, B.*; Jiang, G.. Identification of photochemical methylation products of tin(II) in aqueous solutions using seadspace SPME coupled with GC-FPD or GC-MS. Anal. Methods, 2012, 4, 2109-2114.

  17. Gao J, Li R, Wang F, Liu X, Zhang J, Hu L, Shi J, He B, Zhou Q, Song M, Zhang B, Qu G, Liu S, Jiang G. Determining the Cytotoxicity of Rare Earth Element Nanoparticles in Macrophages and the Involvement of Membrane Damage. Environ. Sci. Technol., 2017, 51, 13938-13948.

  18. Liu L, Liu A, Zhang Q, Shi J, He B, Yun Z, Jiang G. Determination of tetrabromobisphenol-A/S and their main derivatives in water samples by high performance liquid chromatography coupled with inductively coupled plasma tandem mass spectrometry. J. Chromatogr A., 2017, 1497, 81-86.

  19. Yiling Li, Bin He, Qiying Nong, Guangbo Qu, Lihong Liu, Jianbo Shi, Ligang Hu*, and Guibin Jiang. Characterization of mercury-binding proteins in rat blood plasma. Chem. Commun., 2018, 54, 7439-7442.

  20. Yiling Li, Bin He, Jiejun Gao, Qian S. Liu, Runzeng Liu, Guangbo Qu, Jianbo Shi, Ligang Hu*, Guibin Jiang. Methylmercury exposure alters RNA splicing in human neuroblastoma SK-N-SH: Implications from proteomic and post-transcriptional responses. Environ. Pollut., 2018, 238, 213-221.

  21. Dingyi Wang, Xiu Huang, Jie Li, Bin He, Qian Liu*, Ligang Hu* and Guibin Jiang. 3D printing of graphene-doped target for “matrix-free” laser desorption/ionization mass spectrometry. Chem. Commun., 2018, 54, 2723-2726.

  22. E Hudgens, Z Drobna, B He, X C Le, M Styblo, J Rogers and D J Thomas. Biological and behavioral factors modify urinary arsenic metabolic profiles in a U.S. population. Environ. Health, 2016, 15, 62-75.

  23. Mei Meng, Jianbo Shi*, Chengbin Liu, Nali Zhu, Junjuan Shao, Bin He, Yong Cai and Guibin Jiang. Biomagnification of mercury in mollusks from coastal areas of the Chinese Bohai Sea. RSC Adv., 2015, 5, 40036-40045.

  24. Lihong Liu, Bin He, Qian Liu*, Zhaojun Yun, Xueting Yan, Yanmin Long and Guibin Jiang. Identification and Accurate Size Characterization of Nanoparticles in Complex Media. Angew. Chem. Int. Ed., 2014, 53, 14476-14479.

  25. Suzhen Cao，Xiaoli Duan*，Xiuge Zhao, Jin Ma, Ting Dong, Nan Huang, Chengye Sun, Bin He, Fusheng Wei*. Health risks from the exposure of children to As, Se, Pb and other heavy metals near the largest coking plant in China. Sci. Total Environ., 2014, 472: 1001-1009.

  26. Suzhen Cao，Xiaoli Duan*，Xiuge Zhao, Beibei Wang, Jin Ma, Delong Fan, Chengye Sun, Bin He, Fusheng Wei*, Guibing Jiang. Isotopic ratio based source apportionment of children’s blood lead around coking plant area. Environment International, 2014, 73: 158-166.

  27. Suzhen Cao , Xiaoli Duan,*, Xiuge Zhao, JinMa, Ting Dong, Nan Huang, Chengye Sun, Bin He, FushengWei**. Health risks from the exposure of children to As, Se, Pb and other heavy metals near the largest coking plant in China. Sci. Total Envrion., 2014, 472, 1001-1009

  28. Meng, M.; Li, B.; Shao, J.; Wang, T.; He, B.; Shi, J.*; Ye, Z.; Jiang, G.. Accumulation of total mercury and methylmercury in rice plants collected from different mining areas in China. Environ. Pollut., 2014, 184, 179-186. (IF=3.73)

  29. Rebecca L. Calderon, Edward E. Hudgens, Cara Carty, Bin He, X.Chris Le. Biological and behavioral factors modify biomarkers of arsenic exposure in a U.S. population. Environmental Research, 2013, 126, 134-144

  30. Hu, L.; Cheng, T.; He, B.; Li, L.; Wang, Y.; Lai, Y.; Jiang, G.; Sun, H.*. Identification of metal-associated proteins in cells by using continuous-flow gel electrophoresis and inductively coupled plasma mass spectrometry. Angew. Chem. Int. Ed. 2013, 52, 4916-4920.

  31. Yin, N.; Liu, Q.; Liu J.; He, B.; Cui, L.; Li, Z.; Yun, Z.; Qu, G.; Liu, S.; Zhou, Q.*; Jiang, G.. Silver nanoparticle exposure attenuates the viability of rat cerebellum granule cells through apoptosis coupled to oxidative stress. Small, 2013, 9, 1831-1841.

  32. Li, B.; Shi, J.*; Wang, X.; Meng, M.; Huang, L.; Qi, X.; He, B.; Ye, Z.*. Variations and constancy of mercury and methylmercury accumulation in rice grown at contaminated paddy field sites in three Provinces of China. Environ. Pollut., 2013, 181, 91-97.

  33. Wang, Z.; Yin, Y.; He, B.; Shi, J.; Liu, J.; Jiang, G.*. L-cysteine-induced degradation of organic mercury as a novel interface in the HPLC-CV-AFS hyphenated system for speciation of mercury. J. Anal. At. Spectrom., 2010, 25, 810-814.

  34. Shi, G.; Chen, D.; Zhai, G.; Chen, M.; Cui, Q..; Zhou, Q.; He, B.; Dou, Q.; Jiang, G.*. The Proteasome Is a Molecular Target of Environmental Toxic Organotins. Environ. Health Perspective, 2009, 117, 379-386.

  35. Yin, Y.; Wang, Z.; Peng, J.; Liu, J.; He, B.; Jiang, G.*. Direct chemical vapour generation-flame atomization as interface of high performance liquid chromatography-atomic fluorescence spectrometry for speciation of mercury without using post-column digestion. J. Anal. At. Spectrom., 2009, 24, 1575-1578.

  36. Zhai, G.; Liu, J.; Li, L.; Cui, L.; He, B.; Zhou, Q.; Jiang, G.*. Rapid and direct speciation of methyltins in seawater by an on-line coupled high performance liquid chromatography-hydride generation-ICP/MS system. Talanta, 2009, 77, 1273-1278.

  37. Yin, Y.; Liu, J.; He, B. Shi, J.; Jiang, G.*. Mercury speciation by a high performance liquid chromatography-atomic fluorescence spectrometry hyphenated system with photo-induced chemical vapour generation reagent in the mobile phase. Microchimica Acta, 2009, 167, 289-295

 

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