性别：男

职称：副研究员

邮箱：yinliu@ucas.ac.cn

研究方向：环境暴露与健康效应

工作经历

2021/01-至今，国科大杭州高等研究院，环境学院，副研究员

2020/09-2021/01，山东大学，微生物技术研究院，副研究员。

2018/02-2020/07，Texas A&M University, College Station，药学院，助理研究员，合作导师，朱林。

2016/07-2018/02，中国科学院生态环境研究中心，环境化学与生态毒理学国家重点实验室，博士后，合作导师，赵斌。

承担科研项目

1. 国家自然科学基金青年基金，21707159，噻唑类化合物对二恶英类化合物毒性效应的调节作用及机制研究，2018.01-2020.12，已结题，主持。

2. 国家自然科学基金地区科学基金，22066015，示踪纳米塑料的可控设计及物化性质对其体内命运的影响，2021.01-2024.12，在研，参与。

3. 国家自然科学基金委员会重点项目, 21836004, 二恶英类污染物系统性神经毒理过程与机制研究, 2019.01-2023.12，在研，参与。

代表论著

1. Zhou Xiaofei, Medina-Ramirez E. Iliana, Su Gaoxing, Liu Yin*, Yan Bing*, All Roads Lead to Rome: Comparing Nanoparticle- and Small Molecule-Driven Cell Autophagy. Small 2024, In press.

2. Wang Jiali, Xu Yuhang, Zhou Yun, Zhang Jian, Jia Jianbo, Jiao Peifu, Liu Yin*, Su Gaoxing*, Modulating the toxicity of engineered nanoparticles by controlling protein corona formation: Recent advances and future prospects. Science of The Total Environment 2024, 914, 169590.

3. Zhang Long*, Li Guozhou, Xin Qi, Liu Haonan, Yang Xuezhi, Liu Yin*, AIE-labeled fluorescent polystyrene nanoplastics for quantitative analysis in macrophages uptake. Sensors and Actuators: B. Chemical 2024, 413, 135878.

4. Qi Mengying, Wang Xudong, Chen Jiahao, Liu Yin*, Liu Yun, Jia Jianbo, Li Lingxiangyu, Yue Tongtao, Gao Lirong, Yan Bing, Zhao Bin, Xu Ming*, Transformation, Absorption and Toxicological Mechanisms of Silver Nanoparticles in the Gastrointestinal Tract Following Oral Exposure. ACS Nano 2023, 17, 8851-8865.

5. Zhang Long*, Liu Haonan, Xin Qi, Tang Lijuan, Tang Jie, Liu Yin*, Hu Le, A quantitative study of nanoplastics within cells using magnetic resonance imaging. Science of The Total Environment 2023, 886, 164033.

6. Zhang Peiming, Liu Yin*, Zhang Long, Xu Ming, Gao Lirong, Zhao Bin*, The interaction of micro/nano plastics and the environment: Effects of ecological corona on the toxicity to aquatic organisms. Ecotoxicology and Environmental Safety 2022, 243, 113997.

7. Liu Yin, Zhang Jian, Tu Ying, Zhu Lin*, Potential-Independent Intracellular Drug Delivery and Mitochondrial Targeting. ACS Nano 2022, 16, (1), 1409-1420.

8. Liu Fang, Wang Zengjin, Wei Yongyi, Liu Rongrong, Jiang Cuijuan, Gong Chen, Liu Yin*, Yan Bing*, The leading role of adsorbed lead in PM2.5-induced hippocampal neuronal apoptosis and synaptic damage. Journal of Hazardous Materials 2021, 416, 125867.

9. Liu Yin, Wang Jiao, Zhang Jian, Marbach Sandra, Xu Wei, Zhu Lin*, Targeting Tumor-Associated Macrophages by MMP2-Sensitive Apoptotic Body-Mimicking Nanoparticles. ACS Applied Materials & Interfaces 2020, 12, (47), 52402-52414.

10. Liu Yin, Wei Yongyi, Zhang Songyan, Yan Xiliang, Zhu Hao, Xu Li, Zhao Bin, Xie Heidi Qunhui*, Yan Bing*, Regulation of Aryl Hydrocarbon Receptor Signaling Pathway and Dioxin Toxicity by Novel Agonists and Antagonists. Chemical Research in Toxicology 2020, 33, (2), 614-624.

11. Liu Yin^#, Dai Zhi^#, Wang Jiao, Tu Ying, Zhu Lin*, Folate-targeted pH-sensitive bortezomib conjugates for cancer treatment. Chemical Communications 2019, 55, (29), 4254-4257.

12. Yao Qing^#, Liu Yin^#, Kou Longfa^#, Tu Ying, Tang Xing, Zhu Lin*, Tumor-targeted drug delivery and sensitization by MMP2-responsive polymeric micelles. Nanomedicine: Nanotechnology, Biology and Medicine 2019, 19, 71-80.

13. Liu Yin, Su Gaoxing, Wang Fei, Jia Jianbo, Li Shuhuan, Zhao Linlin, Shi Yali, Cai Yaqi, Zhu Hao, Zhao Bin, Jiang Guibin, Zhou Hongyu*, Yan Bing*, Elucidation of the Molecular Determinants for Optimal Perfluorooctanesulfonate Adsorption Using a Combinatorial Nanoparticle Library Approach. Environmental Science & Technology 2017, 51, (12), 7120-7127.

14. Liu Yin, Li Fei, Wu Ling, Wang Wenyi, Zhu Hao, Zhang Qiu, Zhou Hongyu, Yan Bing*, Improving both aqueous solubility and anti-cancer activity by assessing progressive lead optimization libraries. Bioorganic & Medicinal Chemistry Letters 2015, 25, (9), 1971-1975.

15. Liu Yin, Yan Bing*, Characterizing the Surface Chemistry of Nanoparticles: an Analogy to Solid-Phase Synthesis Samples. ChemInform 2011, 42, (52).

专利

1. 噻唑烷酮衍生物及其在制备抗肿瘤药物中的应用。闫兵，刘寅，李淑焕，穆岩，田聪，张秋，翟淑梅，张斌。专利号：ZL 2012 1 0205143.7。

2. 一种噻唑烷酮化合物及其在制备治疗铁紊乱相关疾病药物中的应用。闫兵，刘思金，刘寅，刘静。专利号：ZL 2014 1 0698860.7。

3. 一种能清除全氟污染物的金纳米颗粒阵列。闫兵，郭聪聪，王飞，江翠娟，刘寅，李淑焕，翟淑梅，张秋，张斌。专利号：ZL 2014 1 0169811.4。

4. 一种利用全纳米探针来鉴别小分子化合物作用靶点的分析方法。闫兵，李丽文，刘寅，张秋，张斌。专利号：ZL 2011 1 0074869.7。

5. 5-(4-羟基-3-甲氧基苯亚甲基)-2-（2-硝基苯亚氨基）噻唑烷酮及应用。闫兵，董梦琦，赵斌，张嵩岩，周宏宇，刘寅，王深清。专利号：ZL 2017 1 0186484.7。

6. 2-（4-三氟甲基苯亚胺基）-5-（2-萘基亚甲基）噻唑烷-4-酮化合物及应用。闫兵，苗潇元，赵斌，张嵩岩，周宏钰，王深清，刘寅。专利号：ZL 2017 1 0184406.3。

7. Zhu L, Liu Y, Tu Y “Intracellular delivery and mitochondrial targeting by fluorination” PCT WO2020/19846 A1

会议

1. Yin Liu, Bin Zhao, “Discovery of Novel Aryl Hydrocarbon Receptor Agonists/antagonists by a Combinational Compounds Library Approach.” The 14th International Symposium on Persistent Toxic Substances, Nagoya, Japan, 24-28 September 2017.

2. Yin Liu, Qing Yao, Zhi Dai, Ying Tu, and Lin Zhu, “Design of stimulus-sensitive polymeric micelles for tumor targeting and drug sensitization.” Polymers for Advanced Technologies, College Station, Texas, U.S., 8-10 August 2019. Awarded as Outstanding Poster.

学术贡献

Topic Editors, Research topic “Nano-bio interactions: Ecotoxicology and Cytotoxicity of Nanomaterials.” Frontiers in Bioengineering and Biotechnology.