性别：男

职称：副研究员

邮箱：yinliu@ucas.ac.cn

研究方向：环境暴露与健康效应

工作经历

2021/01-至今         国科大杭州高等研究院环境学院    副研究员

2020/09-2021/01    山东大学，微生物技术研究院    副研究员

2018/02-2020/07    Texas A&M University, College Station，药学院，助理研究员，合作导师，朱林

2016/07-2018/02    中国科学院生态环境研究中心，环境化学与生态毒理学国家重点实验室，博士后，合作导师，赵斌

承担科研项目

1. 国家自然科学基金面上项目，22476034，基于线粒体靶向研究PFAS对肝脏糖代谢的影响及分子机制，2025.01-2028.12，在研，主持

2. 横向课题，植物性农产品中PFAS提取和高灵敏检测分析，2025，结题，主持

3. 横向课题，可体内示踪纳米粒子的合成工艺，2025.01—2027.12，在研，主持

4. 山东省地质勘查工程技术研究中心开放基金（重点课题），锂电池产业链园区土壤重金属污染评估，2025.02—2026.06，在研，主持

5. 国家自然科学基金青年基金，21707159，噻唑类化合物对二恶英类化合物毒性效应的调节作用及机制研究，2018.01-2020.12，结题，主持

6. 国家自然科学基金地区科学基金，22066015，示踪纳米塑料的可控设计及物化性质对其体内命运的影响，2021.01-2024.12，结题，参与

7. 国家自然科学基金委员会重点项目, 21836004, 二恶英类污染物系统性神经毒理过程与机制研究, 2019.01-2023.12，结题，参与

代表论著

1. Ya Liu, Yin Liu*, Combined Molecular Toxicity Mechanism of Microplastics Mixtures. Combined Molecular Toxicity Mechanism of Microplastics Mixtures. 2025, Chapter 14.

2. Haijun Zhang, Lihua Dai, Fei Wang, Yin Liu*, Shumei Zhai*, An Update Overview of Nanoparticle-Induced Cardiovascular Toxicity. Nanotechnology Reviews 2025, in press.

3. Yali Zhang, Xingpeng Dong, Cuijuan Jiang, Yanyan Yu, Haiyan Zhang, Jianjie Fu, Gaoxing Su*, Yin Liu*. A Competitive Aptamer Binding-Based CRISPR-Cas Biosensor for Sensitive Detection of Tetracycline Residues in Biological Samples. Talanta 2025, 286, 127491.

4. Zhou Xiaofei, Medina-Ramirez E. Iliana, Gaoxing Su, Yin Liu*, Bing Yan*, All Roads Lead to Rome: Comparing Nanoparticle- and Small Molecule-Driven Cell Autophagy. Small 2024, 20 (34), 2310966.

5. Jiali Wang, Yuhang Xu, Yun Zhou, Jian Zhang, Jianbo Jia, Peifu Jiao, Yin Liu*, Gaoxing Su*, Modulating the Toxicity of Engineered Nanoparticles by Controlling Protein Corona Formation: Recent Advances and Future Prospects. Science of The Total Environment 2024, 914, 169590.

6. Long Zhang*, Guozhou Li, Qi Xin, Haonan Liu, Xuezhi Yang, Yin Liu*, AIE-Labeled Fluorescent Polystyrene Nanoplastics for Quantitative Analysis in Macrophages Uptake. Sensors and Actuators: B. Chemical 2024, 413, 135878.

7. Mengying Qi, Xudong Wang, Jiahao Chen, Yin Liu*, Yun Liu, Jianbo Jia, Lingxiangyu Li, Tongtao Yue, Lirong Gao, Bing Yan, Bin Zhao, Ming Xu*, Transformation, Absorption and Toxicological Mechanisms of Silver Nanoparticles in the Gastrointestinal Tract Following Oral Exposure. ACS Nano 2023, 17, 8851-8865.

8. Long Zhang*, Haonan Liu, Qi Xin, Lijuan Tang, Jie Tang, Yin Liu*, Le Hu, A Quantitative Study of Nanoplastics within Cells Using Magnetic Resonance Imaging. Science of The Total Environment 2023, 886, 164033.

9. Peiming Zhang, Yin Liu*, Long Zhang, Ming Xu, Lirong Gao, Bin Zhao*, The Interaction of Micro/nano Plastics and the Environment: Effects of Ecological Corona on the Toxicity to Aquatic Organisms. Ecotoxicology and Environmental Safety 2022, 243, 113997.

10. Yin Liu, Jian Zhang, Ying Tu, Lin Zhu*, Potential-Independent Intracellular Drug Delivery and Mitochondrial Targeting. ACS Nano 2022, 16, (1), 1409-1420.

11. Fang Liu, Zengjin Wang, Yongyi Wei, Rongrong Liu, Cuijuan Jiang, Chen Gong, Yin Liu*, Bing Yan*, The Leading Role of Adsorbed Lead in PM2.5-Induced Hippocampal Neuronal Apoptosis and Synaptic Damage. Journal of Hazardous Materials 2021, 416, 125867.

12. Yin Liu, Jiao Wang, Jian Zhang, Sandra Marbach, Wei Xu, Lin Zhu*, Targeting Tumor-Associated Macrophages by MMP2-Sensitive Apoptotic Body-Mimicking Nanoparticles. ACS Applied Materials & Interfaces 2020, 12, (47), 52402-52414.

13. Yin Liu, Yongyi Wei, Songyan Zhang, Xiliang Yan, Hao Zhu, Li Xu, Bin Zhao, Heidi Qunhui Xie*, Bing Yan*, Regulation of Aryl Hydrocarbon Receptor Signaling Pathway and Dioxin Toxicity by Novel Agonists and Antagonists. Chemical Research in Toxicology 2020, 33, (2), 614-624.

14. Yin Liu#, Zhi Dai#, Jiao Wang, Ying Tu, Lin Zhu*, Folate-Targeted pH-Sensitive Bortezomib Conjugates for Cancer Treatment. Chemical Communications 2019, 55, (29), 4254-4257.

15. Qing Yao#, Yin Liu#, Longfa Kou#, Ying Tu, Xing Tang, Lin Zhu*, Tumor-Targeted Drug Delivery and Sensitization by MMP2-Responsive Polymeric Micelles. Nanomedicine: Nanotechnology, Biology and Medicine 2019, 19, 71-80.

16. Yin Liu, Gaoxing Su, Fei Wang, Jianbo Jia, Shuhuan Li, Linlin Zhao, Yali Shi, Yaqi Cai, Hao Zhu, Bin Zhao, Guibin Jiang, Hongyu Zhou*, Bing Yan*, Elucidation of the Molecular Determinants for Optimal Perfluorooctanesulfonate Adsorption Using a Combinatorial Nanoparticle Library Approach. Environmental Science & Technology 2017, 51, (12), 7120-7127.

17. Yin Liu, Fei Li, Ling Wu, Wenyi Wang, Hao Zhu, Qiu Zhang, Hongyu Zhou, Bing Yan*, Improving Both Aqueous Solubility and Anti-Cancer Activity by Assessing Progressive Lead Optimization Libraries. Bioorganic & Medicinal Chemistry Letters 2015, 25, (9), 1971-1975.

18. Yin Liu, Bing Yan*, Characterizing the Surface Chemistry of Nanoparticles: an Analogy to Solid-Phase Synthesis Samples. ChemInform 2011, 42, (52).

专利

1. 噻唑烷酮衍生物及其在制备抗肿瘤药物中的应用。闫兵，刘寅，李淑焕，穆岩，田聪，张秋，翟淑梅，张斌。专利号：ZL 2012 1 0205143.7。

2. 一种噻唑烷酮化合物及其在制备治疗铁紊乱相关疾病药物中的应用。闫兵，刘思金，刘寅，刘静。专利号：ZL 2014 1 0698860.7。

3. 一种能清除全氟污染物的金纳米颗粒阵列。闫兵，郭聪聪，王飞，江翠娟，刘寅，李淑焕，翟淑梅，张秋，张斌。专利号：ZL 2014 1 0169811.4。

4. 一种利用全纳米探针来鉴别小分子化合物作用靶点的分析方法。闫兵，李丽文，刘寅，张秋，张斌。专利号：ZL 2011 1 0074869.7。

5. 5-(4-羟基-3-甲氧基苯亚甲基)-2-（2-硝基苯亚氨基）噻唑烷酮及应用。闫兵，董梦琦，赵斌，张嵩岩，周宏宇，刘寅，王深清。专利号：ZL 2017 1 0186484.7。

6. 2-（4-三氟甲基苯亚胺基）-5-（2-萘基亚甲基）噻唑烷-4-酮化合物及应用。闫兵，苗潇元，赵斌，张嵩岩，周宏钰，王深清，刘寅。专利号：ZL 2017 1 0184406.3。

会议

1. Yin Liu, Bin Zhao, “Discovery of Novel Aryl Hydrocarbon Receptor Agonists/antagonists by a Combinational Compounds Library Approach.” The 14th International Symposium on Persistent Toxic Substances, Nagoya, Japan, 24-28 September 2017.

2. Yin Liu, Qing Yao, Zhi Dai, Ying Tu, and Lin Zhu, “Design of stimulus-sensitive polymeric micelles for tumor targeting and drug sensitization.” Polymers for Advanced Technologies, College Station, Texas, U.S., 8-10 August 2019. Awarded as Outstanding Poster.

学术贡献

Topic Editors, Research topic “Nano-bio interactions: Ecotoxicology and Cytotoxicity of Nanomaterials.” Frontiers in Bioengineering and Biotechnology.