姓名:陈旸升 |
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性别:男 |
职称:助理研究员 |
邮箱:yschen413@ucas.ac.cn |
研究方向:环境污染物神经毒理机制与生物传感 |
教育经历:
2014.09 – 2018.06,中国科学院生态环境研究中心 博士学位 导师:赵斌研究员
2011.09 – 2014.06,辽宁师范大学 硕士学位 导师: 侯和胜教授
2007.09 – 2011.06,辽宁师范大学 学士学位
工作经历:
2024.09 – 至今,国科大杭州高等研究院环境学院 助理研究员
2024.01 – 2024.08,中国科学院生态环境研究中心 环境化学与生态毒理学国家重点实验室 助理研究员
2018.07 – 2023.12,中国科学院生态环境研究中心 博士后/特别研究助理 (合作导师:郑明辉研究员)
科研项目经历:
1. 国家自然科学基金青年基金,22206202,芳香烃受体活性污染物对星形胶质细胞的激活效应及机制研究,(2023/01-2024/12),20万元,主持。
2. 国家重点研发计划合成生物学专项项目,2018YFA0901100,高灵敏环境持久性有毒污染物感知与识别生物系统,(2019/01-2024/12),2404万元,参与,课题骨干。
3. 国家自然科学基金重点项目,21836004,二恶英类污染物系统性神经毒理过程与机制研究,(2019/01-2023/12),
300万元,已结题,参与。
获奖及荣誉:
1. 2022年,环境保护科学技术奖二等奖(4/8)
2. 2020年,中国科学院生态环境研究中心优秀博士后
代表论著:
1. Zheng LP, Li Q, Du JY, Lu XS, Fan TT, Xu L, Xie QH, Chen YS*, Zhao B, Insight into interaction among soil microbial community, soil metabolomics and enzyme activity after long-term PAHs stress. Journal of Environmental Sciences, 2024, accepted.
2. 彭颖蓓, 陈旸升*, 刘奕耘, 李云平, 徐丽, 谢群慧, 赵斌. TCDD对胶质母细胞瘤中环氧合酶2基因表达的影响和生物学作用.生态毒理学报,2023,18(4),241-252.
3. 陈旸升, 马永超, 彭颖蓓, 徐丽, 谢群慧*, 赵斌. 苯线磷和甲胺磷对TF-1细胞乙酰胆碱酯酶影响的差异. 生态毒理学报,2023,18(4),231-240.
4. Liu.YY#, Chen YS#, Sha R, Li YP, Xu T, Hu XX, Xu L, Xie QH*, Zhao B*. A new insight into the role of aryl hydrocarbon receptor (AhR) in the migration of glioblastoma by AhR-IL24 axis regulation. Environment International, 2021, 154, 106658.
5. Chen YS, Xie QH, Sha R, Xu T, Zhang SY, Fu HL, Xia YJ, Liu YY, Xu L*, Zhao B*. 2,3,7,8-Tetrachlorodibenzo-p-dioxin and up-regulation of neurofilament expression in neuronal cells: Evaluation of AhR and MAPK pathways. Environment International, 2020, 134, 105193.
6. Chen YS, Sha R, Xu L, Xia YJ, Liu YY, Li YJ, Xie QH*, Tang NJ, Zhao B*. 2,3,7,8-Tetrachlorodibenzo-p-dioxin promotes migration ability of primary cultured rat astrocytes via aryl hydrocarbon receptor. Journal of Environmental Sciences, 2019,76,368-376.
7. Wen ZL, Zhang YB, Zhang BR, Hang YM, Xu L, Chen YS, Xie QH, Zhao Q, Zhang LH, Li GH, Zhao B, Sun F*, Zhai YJ*, Zhu Y*. Cryo-EM structure of the cytosolic AhR complex. Structure, 2023,31(3),295-308.
8. Xu T, Luo YL, Xie HQ*, Xia YJ, Li YP, Chen YS, Guo ZL, Xu L, Zhao B*. Systematic identification of molecular mechanisms for aryl hydrocarbon receptor mediated neuroblastoma cell migration. Environment International, 2022,168,107461.
9. Zhang SY, Zhang H, Chen YS, Yang HY, Qu JL, Xu L, Zheng LP, Xie QH, Jiang YS, Zhang JQ, Bi WC, Zhang J*, Zhao B*. Application of a ready-to-use cell sensor for dioxins and dioxin-like compounds screening in foodstuffs. Science of the Total Environment, 2022,838(Pt 3), 156227.
10. Sha R, Chen YS, Wang YJ, Luo YL, Liu YY, Ma YC, Li YP, Xu L, Xie HQ*, Zhao B. Gestational and lactational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin in mice: Neurobehavioral effects on female offspring. Science of the Total Environment, 2021,752,141784.
11. Liu YY, Chen YS, Zhu RH, Xu L, Xie HQ, Zhao B. Rutaecarpine Inhibits U87 Glioblastoma Cell Migration by Activating the Aryl Hydrocarbon Receptor Signaling Pathway. Frontiers in molecular neuroscience, 2021,14,765712.
12. Sha R, Chen YS, Luo YL, Liu YY, Xu L, Xie HQ*, Zhao B*. Effects of astrocyte conditioned medium on neuronal AChE expression upon 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure. Chenico-biological interactions, 2019,309:108686.