教育经历：

2016.09 – 2019.06，中国科学院生态环境研究中心（环境化学与生态毒理学国家重点实验室），博士，导师：郭良宏 研究员

2013.09 – 2016.06，南京农业大学，硕士，导师：曹慧 教授

2009.09 – 2013.06，鲁东大学，学士

工作经历：

2024.10 – 至今，国科大杭州高等研究院环境学院，特聘副教授（硕导）

2019.08 – 2024.09，青岛大学公共卫生学院，讲师（硕导）

承担科研项目：

1. 山东省自然科学基金面上项目，ZR2024MH144，六氟环氧丙烷三聚羧酸拮抗法尼醇X受体通路致胆汁淤积型肝损伤的机制研究，（2025/01-2027/12），10万元，主持。

2. 国家自然科学基金青年基金项目，82103875，PPARγ介导的miR378c在F-53B诱导肝脂脂代谢紊乱中的调控机制研究，（2022/01–2024/12），30万元，已结题，主持。

3. 山东省自然科学基金青年基金项目，ZR2020QH295，hsa-miR-532调控PFOA新型替代品六氟环氧丙烷低聚物致肝脂代谢紊乱机制的研究，（2021/01-2023/12），14万元，已结题，主持。

4. 国家自然科学基金面上项目，82273670，基于单细胞转录组研究肝窦内皮细胞JAM2高表达致酒精肝相关免疫细胞跨内皮迁移浸润的作用机制，（2023/01-2026/12），52万元，参与。

5. 国家自然科学基金面上项目，82273661，含铁添加剂柴油机尾气吸入致心肺发育毒性研究及机制探索，（2023/01-2026/12），52万元，参与。

6. 国家自然科学基金面上项目，21777187，基于脂肪酸膜受体GPR40信号通路探讨全氟烷基化合物的胰岛素分泌功能干扰效应及其分子作用机制，（2018/01-2021/12），65万元，已结题，参与。

代表论著：

1. Lanchao Sun, Xinya Liu, Jingyue Du, Huizi Yang, Yongfeng Lin, Dianke Yu, Chuanhai Li*, Yuxin Zheng. Adipogenic Effects of Cresyl Diphenyl Phosphate (Triphenyl Phosphate Alternative) through Peroxisome Proliferator-Activated Receptor Gamma Pathway: A Comprehensive Study Integrating In Vitro, In Vivo, and In Silico from Molecule to Health Risk, Environmental Science & Technology, 2024, 58(42), 18631-18641.

2. Chuan-Hai Li, Ya-Li Shi, Min-Jie Li, Liang-Hong Guo, Ya-Qi Cai. Receptor-Bound Perfluoroalkyl Carboxylic Acids Dictate Their Activity on Human and Mouse Peroxisome Proliferator-Activated Receptor γ [J]. Environmental science & technology, 2020, 54 (15), 9529-9536.

3. Chuan-Hai Li, Xiao-Min Ren, Ting Ruan, Lin-Ying Cao, Yan Xin, Liang-Hong Guo, and Guibin Jiang. Chlorinated polyfluorinated ether sulfonates exhibit higher activity toward peroxisome proliferator-activated receptors signaling pathways than perfluorooctanesulfonate [J]. Environmental science & technology, 2018, 52 (5), 3232–3239.

4. Chuan-Hai Li, Xiao-Min Ren, Liang-Hong Guo. Adipogenic Activity of Oligomeric Hexafluoropropylene Oxide (Perfluorooctanoic Acid Alternative) through Peroxisome Proliferator-Activated Receptor γ Pathway [J]. Environmental science & technology, 2019, 53 (6), 3287-3295.

5. Xinya Liu, Lanchao Sun, Yongfeng Lin, Jingyue Du, Huizi Yang, Chunahai Li*. Cresyl diphenyl phosphate (a novel organophosphate ester) induces hepatic steatosis by directly binding to liver X receptor α: From molecule action to risk assessment, Environment International, 2024, 194, 109168.

6. Donghui Zhang, Xinya Liu, Lanchao Sun, Daochuan Li, Jingyue Du, Huizi Yang, Dianke Yu, Chuanhai Li*. Fine particulate matter disrupts bile acid homeostasis in hepatocytes via binding to and activating farnesoid X receptor. Toxicology, 2024, 506, 153850.

7. Lanchao Sun, Chuanhai Li*. A High-Throughput Screening Approach for Evaluating the Binding Affinity of Environmental Pollutants to Nuclear Receptors. J. Vis. Exp. 2024, 211, e67327.

8. Heming Han, Hao Liu, Bo Zhang, Yue Li, Chuanhai Li*, Hui Cao*. Competitive relationships due to similar nutrient preferences reshape soil bacterial metacommunities. Science of the Total Environment, 2024, 933, 172956.

9. Chuanhai Li, Lidan Jiang, Donghui Zhang, Yuan Qi, Xinyi Wang, Yuan Jin, Xinya Liu, Yongfeng Lin, Jiao Luo, Lin Xu, Kunming Zhao, Dianke Yu. Human health risk assessment of 6:2 Cl-PFESA through quantitative in vitro to in vivo extrapolation by integrating cell-based assays, an epigenetic key event, and physiologically based pharmacokinetic modeling. Environment international, 2023, 173, 107846.

10. Xinya Liu, Lanchao Sun, Shangning Wu, Penghao Wang, Zhaoze Wang, Mengfan Zhai, Jiayi Xu, Donghui Zhang, Dianke Yu, Chuanhai Li*. Toxicity and risk priority ranking of polybrominated diphenyl ethers (PBDEs): A relative receptor-bound concentration approach. Science of the total environment, 2023, 892, 164714.

11. Donghui Zhang, Xinya Liu, Yuan Qi, Yongfeng Lin, Kunming Zhao, Yuan Jin, Jiao Luo, Lin Xu, Dianke Yu, Chuanhai Li*. Binding, activity and risk assessment of bisphenols toward farnesoid X receptor pathway: In vitro and in silico study. Science of the total environment, 2023, 869, 161701.

12. Chuanhai Li, Lidan Jiang, Yuan Qi, Donghui Zhang, Xinya Liu, Wenchao Han, Wanli Ma, Lin Xu, Yuan Jin, Jiao Luo, Kunming Zhao, Dianke Yu. Integration of metabolomics and proteomics reveals the underlying hepatotoxic mechanism of perfluorooctane sulfonate (PFOS) and 6:2 chlorinated polyfluoroalkyl ether sulfonic acid (6:2 Cl-PFESA) in primary human hepatocytes. Ecotoxicology and environmental safety, 2023, 249, 114361.

13. Chuanhai Li, Donghui Zhang, Lidan Jiang, Yuan Qi, Lianghong Guo. Binding and activity of bisphenol analogues to human peroxisome proliferator-activated receptor β/δ [J]. Ecotoxicology and environmental safety, 2021, 226, 112849.

14. Chuanhai Li, Lidan Jiang, Yuan Jin, Donghui Zhang, Jing Chen, Yuan Qi, Rongrong Fan, Jiao Luo, Lin Xu, Wanli Ma, Kunming Zhao, Dianke Yu. Lipid metabolism disorders effects of 6:2 chlorinated polyfluorinated ether sulfonate through Hsa-miRNA-532-3p/Acyl-CoA oxidase 1(ACOX1) pathway [J]. Ecotoxicology and environmental safety, 2021, 228, 113011.

15. Chuan-Hai Li, Xiao-Min Ren, Lin-Ying Cao, Wei-Ping Qin, Liang-Hong Guo. Investigation of binding and activity of perfluoroalkyl substances to human peroxisome proliferator-activated receptor β/δ[J]. Environmental Science: Processes & Impacts, 2019, 21(11): 1908-1914.