教育经历：

2017.9-2021.7 中国科学院动物研究所 博士学位 导师：戴家银研究员

2014.9-2017.6 上海海洋大学 硕士学位 导师：陈松林院士

2009.9-2013.6 烟台大学 学士学位

工作经历：

2021.7-今 国科大杭州高等研究院，环境学院，博士后

承担科研项目：

1. 中国博士后科学基金面上项目, 2021M703404, 肝肠循环在铅的代谢中的作用机制研究, 2022-01 至今, 8万元, 在研, 主持

2. 国家自然科学基金重大项目, 22193052, 生命过程中外源污染物的暴露途径和归趋, 2022-01-01 至 2026-12-31, 431万元, 在研, 参与

奖励与荣誉：

1. 2019 博士研究生国家奖学金 国科大三好学生标兵

2. 2020 地奥奖学金

3. 2021 中科院院长优秀奖

代表论著：

1. Guo, H.; Wang, J.; Yao, J.; Sun, S.; Sheng, N.; Zhang, X.; Guo, X.; Guo, Y.; Sun, Y.; Dai, J., Comparative Hepatotoxicity of Novel PFOA Alternatives (Perfluoropolyether Carboxylic Acids) on Male Mice. Environ. Sci. Technol. 2019, 53, (7), 3929-3937.

2. Guo, H.; Chen, J.; Zhang, H.; Yao, J.; Sheng, N.; Li, Q.; Guo, Y.; Wu, C.; Xie, W.; Dai, J., Exposure to GenX and Its Novel Analogs Disrupts Hepatic Bile Acid Metabolism in Male Mice. Environ. Sci. Technol. 2021.

3. Guo, H.; Zhang, H.; Sheng, N.; Wang, J.; Chen, J.; Dai, J., Perfluorooctanoic acid (PFOA) exposure induces splenic atrophy via overactivation of macrophages in male mice. J. Hazard. Mater. 2021, 407.

4. Guo, H.; Sheng, N.; Guo, Y.; Wu, C.; Xie, W.; Dai, J., Exposure to GenX and its novel analogs disrupts fatty acid metabolism in male mice. Environ. Pollut. 2021, 291.

5. Guo, H.; Wei, M.; Liu, Y.; Zhu, Y.; Xu, W.; Meng, L.; Wang, N.; Shao, C.; Lu, S.; Gao, F.; Cui, Z.; Wei, Z.; Zhao, F.; Chen, S., Molecular cloning and expression analysis of the aqp1aa gene in half-smooth tongue sole (Cynoglossus semilaevis). Plos One 2017, 12, (4).

6. Shi, G.; Guo, H.; Sheng, N.; Cui, Q.; Pan, Y.; Wang, J.; Guo, Y.; Dai, J., Two-generational reproductive toxicity assessment of 6:2 chlorinated polyfluorinated ether sulfonate (F-53B, a novel alternative to perfluorooctane sulfonate) in zebrafish. Environ. Pollut. 2018, 243, 1517-1527.

7. Sun, S.; Guo, H.; Wang, J.; Dai, J., Hepatotoxicity of perfluorooctanoic acid and two emerging alternatives based on a 3D spheroid model. Environ. Pollut. 2019, 246, 955-962.

8. Shi, G.; Wang, J.; Guo, H.; Sheng, N.; Cui, Q.; Pan, Y.; Guo, Y.; Sun, Y.; Dai, J., Parental exposure to 6:2 chlorinated polyfluorinated ether sulfonate (F-53B) induced transgenerational thyroid hormone disruption in zebrafish. Sci. Total Environ. 2019, 665, 855-863.

9. Chen, J.; Li, H.; Yao, J.; Guo, H.; Zhang, H.; Guo, Y.; Sheng, N.; Wang, J.; Dai, J., Chronic exposure to PFO4DA and PFO5DoDA, two perfluoroalkyl ether carboxylic acids (PFECAs), suppresses hepatic stress signals and disturbs glucose and lipid metabolism in male mice. J. Hazard. Mater. 2021, 411.

10. Shi, G.; Cui, Q.; Wang, J.; Guo, H.; Pan, Y.; Sheng, N.; Guo, Y.; Dai, J., Chronic exposure to 6:2 chlorinated polyfluorinated ether sulfonate acid (F-53B) induced hepatotoxic effects in adult zebrafish and disrupted the PPAR signaling pathway in their offspring. Environ. Pollut. 2019, 249, 550-559.

11. Sun, S.; Wang, J.; Yao, J.; Guo, H.; Dai, J., Transcriptome analysis of 3D primary mouse liver spheroids shows that long-term exposure to hexafluoropropylene oxide trimer acid disrupts hepatic bile acid metabolism. Sci. Total Environ 2021, 151509-151509.