乐敏
邮件:myue@ucas.acn.cn
研究领域:病原生物学,基因组学,传染性疾病与公共卫生
招生专业:生物学,生物信息学
博士/博导,国家级人才计划(第十三批/2017),浙江省海外高层次人才引进计划特聘专家(2018),浙江省杰出青年基金获得者(2019);2010.7-2017.2美国宾夕法尼亚大学工作(博士后和副研究员);一直致力于病原基因组与生物安全研究。聚焦人兽共患病菌——沙门菌,利用微生物组等大数据分析并结合系统生物学手段,解析了病菌流行传播规律,揭示了病菌跨种感染与持续感染机制,构建了病原大数据预警与风险评估平台。承担国家重点研发计划课题和国家基金等十余项,以通讯作者在Natl Sci Rev,Nat Commun(两篇),EMBO Mol Med,Clinical Infect Dis(两篇),mBio等发表论文80余篇(其中IF5>10论文12篇),引用>3200次,高被引论文五篇;申报/授权国家发明专利共五件,制定团体标准2套。曾获Publons全球同行评议奖、美国微生物学会少数族裔杰出导师奖和二十四届费城感染与免疫大会报告奖等奖项,入选2022年全球前2%顶尖科学家榜单(World's Top 2% Scientists 2022)【美国斯坦福大学和Elsevier联合发布】。受邀参加国际国内会议主旨/特邀报告二十余次。曾参加美国农业科研中心基金、Medjaden青年基金、长江学者、国家重点研发计划项目等评审;担任PLoS Pathogens,mSystems,Foodborne Pathog Dis,Front Microbiol,Front Vet Sci,Microorganisms和Animal Dis等杂志学术编委或副主编,作为审稿人为BMJ,Lancet Microbe,Cell Rep,Emerg Infect Dis,Glob Chang Biol,Microb Genom,Vet Microbiol 等80余本国际学术期刊审稿500余次。受聘联合国FAO/WHO专家JEMRA(2023-2027)参与全球沙门菌风险评估修订。曾为中国科协提交两份有关人兽共患致病菌和细菌耐药性的内参报告。
个人经历及教育背景:
2024.03- 国科大杭州高等研究院生命与健康科学学院 研究员
2024.01-2024.02 浙江大学医学院 研究员
2016.08-2023.12 浙江大学动物科学学院 研究员
2014.08-2016.07 宾夕法尼亚大学(美国) 副研究员
2010.07-2014.07 宾夕法尼亚大学兽医学院(Dieter M. Schifferli 教授) 博士后
2005.09-2010.06 华中农业大学农业微生物学国家重点实验室(陈焕春 院士)博士研究生
2006.10-2008.12 中国医学科学院北京协和医学院病原生物学研究所(金奇 研究员) 交流访问学生
2001.09-2005.06 华中农业大学动物医学院 大学本科
承担项目:
浙江省自然科学基金 重点项目,浙江省科技厅LZ24C180002
国家重点研发计划子课题,科技部-2022YFC2604201
杭州市科学技术局,杭州市重点研发计划项目2022ZDSJ0135
海南省自然科学基金(海南省科技计划三亚崖州湾科技城联合项目)2021JJLH0083
浙江省重点研发计划-2022C02024
浙江省重大项目-2021C02008
国家自然科学基金- 31972166
浙江省重点研发计划-2020C02032
国家重点研发计划,科技部-2018YFD0500501
国家重点研发计划,科技部- 2017YFC1600103
国家级青年人才项目
相关横向课题五项等
代表性论文(从85篇通讯作者论文中筛选)
https://scholar.google.com/citations?hl=fr&user=FgvtTGwAAAAJ&view_op=list_works&sortby=pubdate)
1. Zhou X#, Kang X#, Chen J, Song Y, Jia C, Teng L, Tang Y, Jiang Z, Peng X, Tao X, Xu Y, Huang L, Xu X, Xu Y, Zhang T, Yu S, Gong J, Wang S, Liu Y, Zhu G, Kehrenberg C, Weill FX, Barrow P, Li Y, Zhao G, Yue M* (20230902) Genome degradation promotes Salmonella pathoadaptation by remodeling fimbriae-mediated proinflammatory response. National Science Review 10(10): nwad228. DOI: 10.1093/nsr/nwad228. Published by Oxford University Press
BioArt Highlight [NSR | “以退为进”实现“双赢”,乐敏课题组揭示病原菌宿主适应新机制]
腾讯网-科研进展 [浙大乐敏课题组以鸡白痢沙门菌为模型提出病原菌宿主适应“以退为进”新机制]
ZJU Highlight [动科学院乐敏课题组揭示病原菌宿主适应“以退为进”新机制]
2. Feng Y#, Pan H#, Zheng B#, Li F, Teng L, Jiang Z, Feng M, Zhou X, Peng X, Xu X, Wang H, Wu B, Xiao Y, Baker S, Zhao G, Yue M* (20231006) An integrated nationwide genomics study reveals transmission modes of typhoid fever in China. mBio 14(5):e0133323. DOI: 10.1128/mbio.01333-23.
Published by American Society for Microbiology.
iMeta Highlight [跨学科/单位联合揭示我国伤寒的“双重”传播模式]
ASM微生物 Highlight [跨学科/单位的基因组学综合研究揭示中国伤寒的“双重”传播模式]
入选ASM Journals’ Diversity, Equity, and Inclusion (DEI) Article Collection
3. Jia C#, Wang Z#, Huang C, Teng L, Zhou H, An H, Liao S, Liu Y, Huang L, Tang B, Yue M* (20231019) Mobilome-driven partitions of the resistome in Salmonella. mSystems 8(6):e0088323. DOI: 10.1128/msystems.00883-23.
Published by American Society for Microbiology.
iMeta Highlight [浙大乐敏组揭示沙门菌可移动元件介导驱动耐药性传播的关键因素]
4. Li Y#, Teng L#, Xu X#, Li X, Peng X, Zhou X, Du J, Tang Y, Jiang Z, Wang Z, Jia C, Müller A, Kehrenberg C, Wang H, Wu B, Weill FX, Yue M* (20221108) A non-typhoidal Salmonella serovar domestication accompanying enhanced niche adaptation. EMBO Molecular Medicine 14(11):e16366.DOI: 10.15252/emmm.202216366.
Published by Wiley-Blackwell & European Molecular Biology Organization
5. Li Y#, Ed-Dra A#, Tang B#, Kang X#, Müller A, Kehrenberg C, Jia C, Pan H, Yang H, Yue M* (20220915) Higher tolerance of predominant Salmonella serovars circulating in the antibiotic-free feed farms to environmental stresses. Journal of Hazardous Materials 438:129476. DOI: 10.1016/j.jhazmat.2022.129476. ESI highly cited paper
Published by Elsevier
6. Peng X#, Ed-Dra A#, Yue M* (20220613) Application of Whole Genome Sequencing for the Risk Assessment of Probiotic Lactic Acid Bacteria. Critical Reviews in Food Science and Nutrition 13:1-19. DOI: 10.1080/10408398.2022.2087174. ESI highly cited paper / hot paper
Published by Taylor & Francis
7. Zhou X#, Kang X#, Zhou K, Yue M* (20220813) A global dataset for prevalence of Salmonella Gallinarum between 1945 and 2021. Scientific Data 9(1):495. DOI:10.1038/s41597-022-01605-x. ESI highly cited paper
Published by Nature Portfolio
8. Paudyal N, Yue M* (20190702) Antibiotic resistance in the “dark matter”. Clinical Infectious Diseases 69(2):379-380. DOI: 10.1093/cid/ciz007.
Published by Oxford University Press & Infectious Diseases Society of America
9. Liu Y, Peng Na, Yao Y, Zhang X, Peng X, Zhao L, Wang J, Peng L, Wang Z, Mochizuki K*, Yue M*, Yang S* (20220623) Breaking the Nanoparticle’s Dispersible Limit via Rotatable Surface Ligands. Nature Communications 13(1):3581. DOI: 10.1038/s41467-022-31275-7.
Published by Nature Portfolio
【Editors’ Highlights: selected as 50 best papers in the field in NC】
Highlighted News: Adaptable, Smart Nanoparticles that can Disperse in Liquids
10. Huang L#, Zhou H#, Chen J, Jia C, Siddique A, Wu B, Wang H, Tang B, He F, Zhao G, Yue M* (20240523) Impact of COVID-19-related Nonpharmaceutical Interventions on Diarrheal Diseases and Zoonotic Salmonella. hLife 2(5):246-256. DOI: 10.1016/j.hlife.2024.03.005.
Published by Elsevier
当期封面论文(Vol.2|Issue 5|May 2024)
BioArtMED highlight [乐敏课题组《hLife》《mLife》研究成果揭示沙门菌中国流行新趋势]
学术论著:
6. Jia C, Wang Z, Zhou H, Liu Y, Yue M*. Chapter 13. Salmonella Phylogenomic. Phylogenomics: Foundations, Methods, and Pathogen Analysis (ISBN: 9780323998864), Elsevier/Academic Press; 2nd edition (December 15, 2023)
5. Pan H, Yue M*. Chapter 32 Salmonella. Molecular detection of foodborne pathogens 2nd edition, 2022 in press
4. Yue M*. Chapter 26 Enterobacter. Molecular detection of foodborne pathogens 2nd edition, 2022 in press.
3. Nambiar R, Yue M*. Chapter 15. Persistence Phenotype. Page 433-460. Stress Response of Foodborne Pathogens (ISBN 978-3-030-90577-4), Springer Nature Press. 2022. DOI: 10.1007/978-3-030-90578-1_15.
2. Zhu C, Yue M, Zhu G. From the known to the unknown: a comparative analysis of Salmonella enterica fim and its ortholog sfm in Escherichia coli. In: Shulin Liu Editor. Salmonella and Escherichia coli: Genomic and Pathogenic Evolution. In Press
1. Bei W, Chen H, Zhou R, Fu S, Yue M. Advance in Genome of Haemophilus parasuis. Ziduo Liu Editor. China Microbial Genome Research p107-115 (Oct 2012) (Book chapter in Chinese).
学术兼职等
联合国粮农组织/世界卫生组织 微生物风险评估委员会委员(2023-2027)
常务理事(2022-2026),中国畜牧兽医学会兽医食品卫生学分会
委员(2021.10-2026.10),中国微生物学会兽医微生物学专业委员会
理事(2022-2026),中国畜牧兽医学会兽医公共卫生学分会
固定人员(2020.7-2025.6),传染病诊治国家重点实验室
学术期刊:
编委(2024-),PLoS Pathogens (IF5=6.7); Academic Editor
编委(2023-2026),mSystems (IF5=7.3); Board of Editors
编委(2022-),Microorganisms (IF5=4.8); Editorial Board Member
编委(2022-),Animal Research and One Health; Editorial Board Member
编委(2022-),Frontiers in Marine Science (IF5=4.7); Review Editor
副主编(2022-),Frontiers in Microbiology (IF5=6.2); Associate Editor
编委(2021-2023),Animal Diseases; Editorial Broad Member
编委(2017-),Foodborne Pathogens and Disease (IF5=3.2); Editorial Broad Member
编委(2018-),Frontiers in Microbiology (IF5=6.2); Review Editor
编委(2018-2020),Frontiers in Nutrition; Review Editor
编委(2019-2020),Frontiers in Veterinary Science; Review Editor
副主编(2020-),Frontiers in Veterinary Science (IF5=3.5); Associate Editor
已培养博士/硕士二十余名,团队具有积极拼搏,奋发向上良好氛围。
考生寄语:仰望星空,脚踏实地,潜心专研,全力以赴。
https://scholar.google.com/citations?hl=fr&user=FgvtTGwAAAAJ&view_op=list_works&sortby=pubdate