教育经历

1998/9–2002/7, 香港科技大学, 生物学, 博士, 导师: 钱培元教授

1998/9–2002/7, 香港科技大学, 生物学, 硕士, 导师: 钱培元教授

1994/9–1998/7, 中国海洋大学, 海洋生物学, 学士, 导师: 初建松教授

工作经历

2009/7-至今, 中国科学院生态环境研究中心, 环境化学与生态毒理学国家重点实验室, 研究员，博士生导师

2003/1-2009/7, 美国加州大学(University of California, Davis), 环境毒理学系, 项目科学家

2003/1-2006/12, 美国加州大学(University of California, Davis), 博士后, 合作导师: Michael S. Denison

社会任职：

Environmental Health Perspectives 杂志，区域主编

Environmental Health Perspectives 杂志中文版，常务顾问

Toxicological Sciences 杂志，编委会成员

《环境化学》 杂志，编委会成员

中国毒理学会分析毒理学分会专业委员会委员

承担科研项目：

1. 国家基金委国家重大科研仪器研制项目，21527901，高通量多功能成组毒理学分析系统，2016/01-2020/12，9800万元，在研，参与。

2. 国家自然科学基金委杰青，化学环境污染与健康，2016/01-2020/12，400万元，在研，课题负责人。

3. 中国科学院战略性先导科技专项(B 类)，XDB14030401，典型污染物的环境暴露与健康危害机制，2014/01-2018/12，500万元，在研，课题负责人。

4. 国家自然科学基金委面上项目，21277168，二恶英免疫毒理效应分子作用靶点及机理研究，2013/01-2016/12，80 万元，已结题，主持。

5. 国家环境保护公益性科研专项项目，201309029，超高灵敏二恶英类生物检测方法的开发与应用，2013/01-2015/12，493 万元，已结题，主持。

6. 国家自然科学基金委面上项目，21177150，二恶英类污染物神经毒理作用新机制的研究，2012/01-2015/12，65 万元，已结题，主持。

7. 中国科学院知识创新工程重要方向项目，KZCX2-EW-411，二恶英类污染物免疫毒性的分子机理研究，2011/01-2013/12，150 万元，已结题，主持。

8. 国家重点基础研究计划项目（973）课题，2010CB933502， 纳米材料与技术在水中污染物选择性消除中的应用基础研究，2010/01-2014/12，770 万元，已结题，主持。

9. 国家自然科学基金委创新群体项目，20921063，持久性有毒化学污染物形态，环境过程与毒理效应，2010/1-2012/12，550 万元，已结题，参加（群体成员）。

获奖及荣誉：

1. 中科院杰出科技成就奖（2013年）

2. 获“国家杰出青年科学基金”（2015年）

代表性论文：

1. Tao WQ, Tian JJ, Xu T, Xu L, Xie Heidi, Zhou ZG, Guo ZL, Fu HL, Yin XJ, Chen YS, Xu HM, Zhang SY, Zhang WL, Ma C, Ji F, Yang J, Zhao B. Metabolic profiling study on potential toxicity in male mice treated with Dechlorane 602 using UHPLC-ESI-IT-TOF-MS. Environmental Pollution. (In Press).

2. Hualing Fu, Li Wang, Jiajia Wang, Bennett Brian D, Jianliang Li, Bin Zhao, Guang Hu. Dioxin and AHR impairs mesoderm gene expression and cardiac differentiation in human embryonic stem cells. Science of The Total Environment, 2019, 651, 1038-1046.

3. SongYan Zhang， ShuaiZhang Li, ZhiGuang Zhou, HuaLing Fu, Li Xu, Heidi Qunhui Xie, Bin Zhao. Development and Application of a Novel Bioassay System for Dioxin Determination and Aryl Hydrocarbon Receptor Activation Evaluation in Ambient-Air Samples. Environmental Science & Technology, 2018, 52, 2926-2933.

4. Hualing Fu, Yingjie Xia, Yangsheng Chen, Tuan Xu, Li Xu, Zhiling Guo, Haiming Xu, Qunhui Xie, Bin Zhao. Acetylcholinesterase Is a Potential Biomarker for a Broad Spectrum of Organic Environmental Pollutants. Environmental Science & Technology, 2018, 52, 8065-8074.

5. Bing Yan, Sijin Liu, Bin Zhao, Xiangdong Li, Qiang Fu, Guibin Jiang. China’s Fight for Clean Air and Human Health. Environmental Science & Technology, 2018, 52, 8063-8064.

6. Zhiling Guo, Qunhui Xie, Peng Zhang, Yali Luo, Tuan Xu, Yiyun Liu, Hualing Fu, Li Xu, Valsami-Jones E, Boksa P, Bin Zhao. Dioxins as potential risk factors for autism spectrum disorder. Environment International, 2018, 121, 905-915.

7. Qunhui Xie, Yingjie Xia, Tuan Xu, Yangsheng Chen, Hualing Fu, Yunping Li, Yali Luo, Li Xu, Karl W K Tsim, Bin Zhao. 2,3,7,8-Tetrachlorodibenzo-p-dioxin induces alterations in myogenic differentiation of C2C12 cells. Environmental Pollution, 2018, 235, 965-973.

8. Wenjing Tian, Hualing Fu, Tuan Xu, Li Xu, Zhiling Guo, Jijing Tian, Wuqun Tao, Qunhui Xie Bin Zhao. SLC6A19 is a novel putative gene, induced by dioxins via AhR in human hepatoma HepG2 cells. Environmental Pollution, 2018, 237, 508-514.

9. Tuan Xu, Qunhui Xie, Yunping Li, Yingjie Xia, Rui Sha, Lingyun Wang, Yangsheng Chen, Li Xu, Bin Zhao. Dioxin induces expression of hsa-mi R-146b-5p in human neuroblastoma cells. Journal of Environmental Sciences, 2018, 63, 260-267.

10. 马慧，宋博宇，张嵩岩，谢群慧，徐丽，曹征宇，赵斌. 基于荧光素酶报告基因的二英类生物检测法的发展与应用. 中国科学:化学, 2018, 48, 43-52.

11. Tuan Xu, Qunhui Xie, Yunping Li, Yingjie Xia, Yangsheng Chen, Li Xu, Lingyun Wang, Bin Zhao. CDC42 expression is altered by dioxin exposure and mediated by multilevel regulations via AhR in human neuroblastoma cells. Scientific Reports, 2017, 7, 10103.

12. Lingyun Wang, Gangdou Ding, Zhiguang Zhou, Xun Liu, Yixiao Wang, Heidi Qunhui Xie, Tuan Xu, Pu Wang, Bin Zhao. Level and characteristics of polychlorinated dibenzo-p-dioxins and dibenzofurans in feed and feed additives. Journal of Environmental Sciences, 2017, 51, 324-331 .

13. Lingyun Wang, Gangdou Ding, Xun Liu, Yixiao Wang, Heidi Qunhui Xie, Tuan Xu, Zhiguang Zhou, Bin Zhao. Patterns and dietary intake of Polychlorinated Dibenzo-p-Dioxins and Polychlorinated Dibenzofurans in food products in China. Journal of Environmental Sciences, 2016, 51, 165-172.

14. Panhong Zhang, Henriette Selck, Stine Rosendal Tangaa, Chengfang Pang, Bin Zhao. Bioaccumulation and effects of sediment-associated gold- and graphene oxide nanoparticles on Tubifex tubifex. Journal of Environmental Sciences, 2017, 51, 138-145.

15. Yuying Liu, Xiaoyu Liang, Xiaonan Yin, Jiadi Lv, Ke Tang, Jingwei Ma, Tiantian Ji, Huafeng Zhang, Wenqian Dong, Xun Jin, Degao Chen, Yanchun Li, Songyan Zhang, Heidi Q. Xie, Bin Zhao, Tong Zhao, Jinzhi Lu, Zhuo-Wei Hu, Xuetao Cao, F. Xiao-Feng Qin, Bo Huang. Blockade of IDO-kynurenine-AhR metabolic circuitry abrogates IFN-γ-induced immunologic dormancy of tumor-repopulating cells. Nature Communication, 2017, 8, 15207.

16. Zhiling Guo, Changjian Xie, Peng Zhang, Junzhe Zhang, Guohua Wang, Xiao He, Yuhui Ma, Bin Zhao, Zhiyong Zhang. Toxicity and transformation of graphene oxide and reduced graphene oxide in bacteria biofilm. Science of the Total Environment, 2017, 580, 1300-1308 .

17. Yin Liu, Gaoxing Su, Fei Wang, Jianbo Jia, Shuhuan Li, Linlin Zhao, Yali Shi, Yaqi Cai, Hao Zhu, Bin Zhao, Guibin Jiang, Hongyu Zhou, Bing Yan. Elucidation of the Molecular Determinants for Optimal Perfluorooctanesulfonate Adsorption Using a Combinatorial Nanoparticle Library Approach. Environmental Science & Technology, 2017, 51, 7120-7127.

18. Shuaizhang Li, Ruili Huang, Samuel Solomon, Yitong Liu, Bin Zhao, Michael F. Santillo, Menghang Xia. Development and Validation of Cell-Based Assays in Quantitative High-throughput Formats for Identification of Acetylcholinesterase Inhibitors. Biochemical Journal, 2016, 12, 1600715.

19. Shuaizhang Li; Jinghua Zhao; Ruili Huang; Toni Steiner; Maureen Bourner; Michael Mitchell; David C Thompson; Bin Zhao; Menghang Xia. Development and Application of Human Renal Proximal Tubule Epithelial Cells for Assessment of Compound Toxicity. Curr Chem Genom Transl Med, 2017, 11, 19-30.

20. Li Xu, Bin Zhao. Global Environmental Health: An interview with Sally Perreault Darney. National Science Review, 2016, 3, 459-462.

21. Yongyi Wei, Yang Li, Jianbo Jia, Yiguo Jiang, Bin Zhao, Qiu Zhang, Bing Yan. Aggravated hepatotoxicity occurs in aged mice but not in young mice after oralexposure to zinc oxide nanoparticles. NanoImpact, 2016, 3-4, 1-11.

22. Jijing Tian, Guoxiang Yang, Huan-Yuan Chen, Daniel K. Hsu, Alexey Tomilov, Kristin A. Olson, Ali Dehnad, Sarah R. Fish, Gino Cortopassi, Bin Zhao, Fu-Tong Liu, Eric Gershwin, Natalie J. Torok, Joy X. Jiang. Galectin-3 regulates inflammasome activation in cholestatic liver injury. FASEB J, 2016, 30, 4202-4213 .

23. Wuqun Tao, Baodong Liu, Zhiguang Zhou*, Bin Zhao*, Tongyu Wei. 2016. Simultaneous determination of catechins and theaflavins in teas by Ultra-high performance liquid chromatography and triple quadrupole mass spectrometry. Jouranal of Pharmaceutical and Biomedical Analysis, 131, 140-145.

24. Zhiling Guo, Qin Hu, Jijing Tian, Li Yan, Chuanyong Jing, Heidi Qunhui Xie, Wenjun Bao, Robert Rice, Bin Zhao*, Guibin Jiang. Proteomic Profiling Reveals Candidate Markers for Arsenic-Induced Skin Keratosis. Environmental Pollution, 2016, 218, 34-38.

25. Li Xu, Yangsheng Chen, Heidi Xie, Tuan Xu, Hualing Fu, Songyan Zhang, Karl Tsim, Cathy Bi, Bin Zhao. 2,3,7,8-tetrachlorodibenzo-p-dioxin suppress AChE activity in NGF induced differentiated PC12 cells. Chemico-Biological Interactions, 2016, 259, 282-285.

26. Qunhui Xie, Tuan Xu, Yangsheng Chen, Yunping Li, Yingjie Xia, Sherry L. Xu, Lingyun Wang, Karl W. K. Tsim, Bin Zhao. New perspectives for multi-level regulations of neuronal acetylcholinesterase by dioxins. Chemico-Biological Interactions, 2016, 259, 286-290.

27. Yu Feng, Jijing Tian, Heidi Qunhui Xie, Jianwen She, Sherry Li Xu, Tuan Xu, Wenjing Tian, Hualing Fu, Shuaizhang Li, Wuqun Tao, Lingyun Wang, Yangsheng Chen, Songyan Zhang, Wanglong Zhang, Tai L. Guo, Bin Zhao. Acute exposure to chlorinated flame retardant Dechlorane 602 suppressed Th1 and enhanced Th2 immune responses in mice. Environmental Health Perspectives, 2016, 124, 1406-1413.

28. Yu Feng, Jijing Tian, Tuan Xu, Heidi Qunhui Xie, Irina Krylova, Bin Zhao. Chronic TCDD exposure results in the suppression of cellular and humoral immunity and induces lymphomagenic transdifferentiation in mouse B cells. Journal of Environmental Sciences, 2016, 39, 218-227.

29. Wenjing Tian, Xinhui Pei, Heidi Qunhui Xie, Sherry Li Xu, Jijing Tian, Qin Hu, Haiming Xu, Yangsheng Chen, Hualing Fu, Zhengyu Cao, Bin Zhao. Development and characterization of monoclonal antibodies to human aryl hydrocarbon receptor. Journal of Environmental Sciences, 2016, 39, 165-174.

30. Zhiguang Zhou, Yue Ren, Jiazhi Chu, Nan Li, Sen Zhen, Hu Zhao, Shuang Fan, Hui Zhang, Pengjun Xu, Li Qi, Shuting Liang, Bin Zhao. The occurrence and impact of polychlorinated dibenzo-p-dioxins/dibenzofurans in the air and soil around a municipal solid waste incinerator. Journal of Environmental Sciences, 2016, 44, 244-251.

31. Xichun Li, Ruy Zhang, Bin Zhao, Christoph Lossin, Zhengyu Cao. Cardiotoxicity screening: a review of rapid throughput in vitro approaches. Archives of Toxicology, 2016, 90, 1803-1816.

32. Yi Zhang, Yabin Wang, Aijuan Liu, Sherry Li Xu, Bin Zhao, Yi Zhang, Hanfa Zou, Wenyi Wang, Hao Zhu and Bing Yan. Modulation of Carbon Nanotube's Perturbation to the Metabolic Activity of CYP3A4 in the Liver. Advanced Functional Materials, 2016, 26, 841-850 .

33. Jijing Tian, Yu Feng, Hualing Fu, Heidi Qunhui Xie, Joy Xiaosong Jiang, Bin Zhao. The Aryl Hydrocarbon Receptor: A Key Bridging Molecule of External and Internal Chemical Signals and Physiological Functions. Environmental Science and Technology, 2015, 49, 9518-9531.

34. Jing Ma, Xi Chen, Yanan Liu, Qunhui Xie, Yawen Sun, Jingshan Chen, Ling Leng, Huan Yan， Bin Zhao, Naijun Tang. Ancestral TCDD exposure promotes epigenetic transgenerational inheritance of imprinted gene Igf2: Methylation status and DNMTs. Toxicology and Applied Pharmacology, 2015, 289(2):193-202.

35. Wuqun Tao, Zhiguang Zho, Li Shen, Bin Zhao. Determination of Dechlorane compounds in Soil and Fish at Guiyu, an Electronic Waste Recycling Site in South China. Environmental Pollution, 2015, 206, 361-368.

36. Nobuko Serizawa, Jijing Tian, Hiroo Fukada, Kornelia Baghy, Fiona Scott, Xiangling Chen, Zsofia Kiss, Kristin Olson, Dan Hsu, Fu-Tong Liu, Natalie J T？r？k, Bin Zhao, Joy Jiang. Galectin 3 Regulates HCC cell invasion by RhoA and MLCK activation. Lab Invest., 2015, 95, 1145-1156.

37. Chengfang Pang, Andrea Brunelli, Conghui Zhu, Danail Hristozov, Ying Liu, Elena Semenzin, Wenwen Wang, Wuqun Tao, Jingnan Liang, Antonio Marcomini, Chunying Chen*, Bin Zhao. Demonstrating approaches to chemically modify the surface of Ag nanoparticles in order to influence their cytotoxicity and biodistribution after single dose acute intravenous administration. Nanotoxicology, 2015, 1-11.

38. Shuaizhang Li, Wen Zhang, Xuejiao Yin, Shilei Xing, Qunhui Xie, Zhengyu Cao, Bin Zhao. Mouse ATP-binding cassette (ABC) transporters conferring multi-drug resistance. Anti-Cancer Agents in Medicinal Chemistry, 2015, 15, 423-432.

39. 管玉峰，赵斌，佘建文。人体生物监测的现状、挑战与展望。Environmental Health Perspectives (Chinese) (环境健康展望中文版)，2015, 121, 3-4.

40. Haiming Xu, Heidi Xie, Wuqun Tao, Zhiguang Zhou, Shuaizhang Li, Bin Zhao. Dioxin and dioxin like compounds suppress acetylcholinesterase activity via transcriptional down-regulations in vitro. Journal of Molecular Neuroscience, 2014, 53, 417-423.

41. Conghui Zhu, Heidi Xie, Bin Zhao. The Role of AhR in Autoimmune Regulation and Its Potential as a Therapeutic Target against CD4 T Cell Mediated Inflammatory Disorder. International Journal of Molecular Sciences, 2014, 15, 10116-10135.

42. Shuaizhang Li, Xinhui Pei, Wen Zhang, Heidi Xie, Bin Zhao. Functional Analysis of the Dioxin Response Elements (DREs) of the Murine CYP1A1 Gene Promoter: Beyond the Core DRE Sequence. International Journal of Molecular Sciences, 2014, 15, 6475-6487.

43. Zhiguang Zhou, Bin Zhao, Li Qi, Pengjun Xu, Yue Ren, Nan Li, Senzheng Hu Zhao, Shuang Fan, Ting Zhang, Aimin Liu, Yeru Huang, Li Shen. Distribution of Polychlorinated Dibenzo-p-dioxins and Dibenzofurans in the Atmosphere of Beijing, China. Aerosol and Air Quality Research, 2014, 14, 1269-1278.

44. Zhiguang Zhou, Bin Zhao, Hiroyuki Kojima, Shinji Takeuchi, Yoko Takagi, Norio Tateishi, Mitsuru Iida, Takuya Shiozaki, Pengjun Xu, Li Qi, Yue Ren, Nan Li, Sen Zheng , Hu Zhao, Shuang Fan, Ting Zhang, Aimin Liu, Yeru Huang. Simple and rapid determination of PCDD/Fs in flue gases from various waste incinerators in China using DR-EcoScreen cells. Chemosphere, 2014, 102, 24-30.

45. Qin Hu, Robert H. Rice, Qin Qin, Brett S. Phinney, Richard A. Eigenheer, Wenjun Bao, Bin Zhao. Proteomic Analysis of Human Keratinocyte Response to 2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD) Exposure. Journal of Proteome Research, 2013, 12, 5340-5347.

46. Bin Zhao. Perspectives of the Development Strategies for a Future Toxicity Testing System in China: Challenges and Opportunities. Environmental Health Perspectives, 2013, 121, 264-265.

47. Qin Hu, Guochun He, Jing Zhao, Anatoly Soshilov, Michael S. Denison, Aiqian Zhang, Huijun Yin, Qunhui Xie, Bin Zhao. Ginsenosides Are Novel Naturally-Occurring Aryl Hydrocarbon Receptor Ligands. PLoS ONE, 2013, 8, e66258.

48. Marjorie A. Phillips, Qin Qin, Qin Hu, Bin Zhao, and Robert H. Rice. Arsenite Suppression of BMP Signaling in Human Keratinocytes. Toxicology and Applied Pharmacology, 2013, 269, 290-296.

49. Heidi Xie, Haiming Xu, Hualing Fu, Qin Hu, Wenjing Tian, Xinhui Pei, Bin Zhao. AhR-Mediated Effects of Dioxin on Neuronal Acetylcholinesterase Expression in Vitro. Environmental Health Perspectives, 2013, 121, 613-618.

50. 赵斌，谢群慧. 二恶英类持久性有机污染物与老年痴呆可能存在相关性. Environmental Health Perspectives (Chinese Ed.), 2013, 121, 3-4.

51. Bin Zhao, Jessica E. S. Bohonowych, Alicia Timme-Laragy, Dawoon Jung, Alessandra A. Affatato, Robert H. Rice, Richard T. Di Giulio and Michael S. Denison. Common Commercial and Consumer Products Contain Activators of the Aryl hydrocarbon (Dioxin) Receptor. PLoS ONE, 2013, 8, e56860.

52. Wenjing Tian, Heidi Qunhui Xie, Hualing Fu, Xinhui Pei, Bin Zhao. Immuno-analysis Methods for the Detection of Dioxins and Related Chemicals. Sensors, 2012, 12, 16710-16731.

53. Zhipu Luo, Xiaoli Shi, Qin Hu, Bin Zhao, Mingdong Huang. Structural Evidence of Perfluorooctane Sulfonate Transport by Human Serum Albumin. Chemical Research in Toxicology, 2012, 25, 990-992.

54. Chang Wang, Thanh Wang, Wei Liu, Ting Ruan, Qunfang Zhou, Jiyan Liu, Aiqian Zhang, Bin Zhao, Guibin Jiang. The In Vitro Estrogenic Activities of Polyfluorinated Iodine Alkanes. Environmental Health Perspectives, 2012, 120, 119-125.

55. Michael Denison, Anatoly Soshilov, Guochun He, Danica DeGroot, Bin Zhao. Exactly the same but different: promiscuity and diversity in the molecular mechanisms of Action of the Aryl Hydrocarbon (Dioxin) Receptor. Toxicological Sciences, 2011, 124, 1-12.

56. Guochun He, Tomoaki Tsutsumi, Bin Zhao, David S. Baston, Jing Zhao, Sharon Heath-Pagliuso, Michael S. Denison. Third generation of Ah receptor-responsive luciferease reporter plasmids: amplification of dioxin responsive elements dramatically increases CALUX bioassay sensitivity and responsiveness. Toxicological Sciences. 2011, 123, 511-522.

57. Guochun He, Bin Zhao, Michael S. Denison. Identification of Benzothiazole Derivatives and Polycyclic Aromatic Hydrocarbons as Aryl Hydrocarbon Receptor Agonists Present in Tire Extracts. Environmental Toxicology and Chemistry, 2011, 30, 1915-1925.

58. Yu Wang, Dazhou Yang, Abraham Chang, William K. Chan, Bin Zhao, Michael S. Denison, Liang Xue. Synthesis of a ligand–quencher conjugate for the ligand binding study of the aryl hydrocarbon receptor using a FRET assay. Med Chem Res, 2011, 21, 711-721.

59. Bin Zhao. Research progress and perspectives of health effects induced by persistent organic pollutants on immunological system (持久性有机污染物免疫健康效应的研究现状及展望). Environmental Health Perspectives (Chinese) (环境健康展望中文版). 2011, 119, 3-4.

60. Bin Zhao, Minghui Zheng, Guibin Jiang. Dioxin Emissions and Human Exposure in China: A Brief History of Policy and Research. Environmental Health Perspectives, 2011, 119, A112-113.

61. Bin Zhao, Danica Degroot, Ai Hayashi, Guochun He, Michael Denison. CH223191 is a ligand-selective antagonist of the Ah (Dioxin) receptor. Toxicological Sciences, 2010, 117, 393-403.