| 姓名：郭良宏 |
 |
| 性别：男 |
| 职称：研究员 |
| 邮箱：lhguo@ucas.ac.cn |
| 研究方向：环境毒理学，环境健康科学，生物分析化学 |
教育经历：
1980.09 - 1985.07 中国科学技术大学应用化学系，本科
1985.09 - 1987.09 武汉大学化学系，硕士研究生
1987.10 - 1990.12 英国牛津大学化学系，博士研究生
1991.01 - 1995.06 美国Rochester大学化学系，博士后
工作经历：
1995.07- 2001.12 美国IGEN International公司，Senior Research Scientist
2002.01- 2004.06 北京博奥生物公司，化学与材料部主任
2004.07- 2019.08 中国科学院生态环境研究中心，研究员，研究组长，国家重点实验室副主任
2019.09- 2024.08 中国计量大学环境与健康科学研究院，院长，研究员
2024.09至今 国科大杭州高等研究院，研究员
承担科研项目：
(1) 国家科技部国家重点研发计划课题：“基于蛋白纳米活性材料和人源类器官的饮用水生殖和代谢毒性污染物鉴定技术”，2023.12 - 2027.11，课题负责人
(2) 国家基金委区域创新发展联合基金重点项目：“基于生物活性等效浓度评估杭州地区含氟有机物污染的健康风险”， 2021.01-2024.12，主持
(3) 浙江省重点研发计划项目：“高端体外诊断检验仪器及试剂研发-高通量电化学发光免疫检测仪及其配套试剂盒的研发”， 2021.01-2024.11，主持
(4) 国家基金委重大研究计划重点项目：“基于颗粒物模型研究PM2.5氧化应激效应的分子机制”， 2016.01-2019.12，主持
(5) 中国科学院前沿科学重点研究项目：“多溴联苯醚生殖发育毒性的关键生物通路”，2016.07-2021.06，主持
(6) 国家基金委重大科研仪器设备研制项目：“高通量多功能成组毒理学分析系统”，2016.01-2020.12，技术骨干
(7) 中国科学院战略性先导科技专项（B类）项目：“污染物的毒性与健康危害机制”，2014.07-2019.06，项目负责人
(8) 国家基金委面上项目：“DNA损伤的电化学发光传感检测方法与应用研究”，2014.01-2017.12，主持
(9) 国家基金委创新研究群体：“持久性有毒污染物的环境过程与毒理效应”，2013.01-2016.12，群体成员
(10) 科技部国家高技术研究发展计划（863）课题：“生活垃圾焚烧厂排放污染物生物检测传感器和生物活性检测技术”，2012.01-2014.12，技术骨干。
(11) 科技部国家重大科学研究计划：“纳米材料的水处理器件化方法及其应用基础研究”，2010.10-2015.08，首席科学家。
(12) 国家基金委面上项目：“基于酪氨酸电化学的蛋白质磷酸化检测”，2009.01-2011.12，50万，主持
(13) 国家基金委杰出青年基金项目：“生物分析化学”，2009.01-2012.12，主持
(14) 国家基金委重大项目课题：“典型持久性污染物的累积代谢及其与生物分子的相互作用”，2009.01-2012.12，课题负责人
(15) 中国科学院重大科研装备研制项目：“环境化合物遗传毒性快速检测仪”， 2008.03-2010.06，主持
(16) 科技部国家高技术研究发展计划（863）课题：“重大环境污染事件特征污染物实验室检测技术系统”，2007.11-2010.11，技术骨干
(17) 科技部国家高技术研究发展计划（863）项目：“环境中具有遗传毒性化学污染物的光电化学快速筛查技术”，2007.01-2009.12，主持
(18) 国家基金委创新研究群体：“持久性有毒污染物形态、环境过程与毒理效应”， 2007.01-2012.12，群体成员。
(19) 国家基金委面上项目：“电化学方法研究环境化合物与核酸的相互作用及其基因毒理”，2007.01-2009.12，主持
(20) 中国科学院“百人计划”项目：“生物分析与生态毒理”，2004.06-2007.05，主持
社会任职：
2014 英国皇家化学会会士 (FRSC)
2023 中国环境科学学会新污染物治理专业委员会常务委员
2016 中国化学会环境化学专业委员会委员
2015 中国化学会分析质谱专业委员会委员
2011 中国毒理学会分析毒理专业委员会常务委员
2008 中国环境科学学会环境医学与健康分会委员
2008 中国仪器仪表学会分析仪器分会电化学分析专业委员会委员
2016 - 2021 《环境化学》主编
2013 - 2019 英国皇家化学会期刊Environmental Science: Processes and Impacts 副主编
2011 - 《分析化学》编委
2011 - 《生态毒理学》编委
2009 - 2015 《环境化学》常务副主编
获奖及荣誉：
2010 中国科学院优秀研究生导师奖
2013 中国科学院杰出科技成就奖 （主要完成人）
2013 国家百千万人才工程“有突出贡献中青年专家”
2015 中国分析测试协会科学技术奖二等奖（排名第二）
2015 国务院政府特殊津贴
2015 中国科学院人事局“特聘研究员”
代表论著：
(1) DongMing Cai, Jinjian Ding, Fangfang Li, Guoqiang Zhuang, Minjie Li*, Liang- Hong Guo*
“Sulfonamide disinfection byproducts exhibited severe toxicity to human commensal bacteria”
Water Research, 2024, 256, 121551.
(2) Fangfang Li, Lu Chen, Bi-Xia Peng, Yuyang Lei, Minjie Li*, Liang-Hong Guo*
“Perfluorooctane sulfonate promotes the migration of colorectal cancer cells by inducing epithelial-mesenchymal transition”
Journal of Environmental Sciences, 2024, 145, 1-12.
(3) 江建明，李敏杰，叶铖，罗海威，洪文俊*，郭良宏*
全氟和多氟烷基物质在人体生物样本中的检测方法与暴露水平研究进展,
《环境化学》，2024.
(4) Bihong Zhang, Zhiquan An, Minjie Li*, Liang-Hong Guo*
“Synthesis, functionalization and photoelectrochemical immunosensing application of WO3-based semiconductor materials”
TrAC-Trends in Analytic Chemistry, 2023, 165, 117149.
(5) Lu Chen, Xicha Lin, Sha Shi, Minjie Li, Monika Mortimer, Wendi Fang, Fangfang Li*, Liang-Hong Guo*
“Activation of estrogen-related receptor: An alternative mechanism of hexafluoropropylene oxide homologs estrogenic effects”
Science of the Total Environment, 2023, 901, 166257.
(6) Danhong Shen, Linyu Shen, Bihong Zhang, Minjie Li, Jinjian Ding*, Liang-Hong Guo*
“Efficient defluorination of perfluorooctanoic acid enabled by single-atom Cu/reduced graphene oxide electrocatalytic anode and peroxymonosulfate”
Chemical Engineering Journal, 2023, 475, 146118.
(7) Bin Xu, Zhiquan An, Minjie Li, Bihong Zhang*, Liang-Hong Guo*
“Photocatalytic degradation of tetrabromobisphenol A by Z-scheme WO3/ ZnIn2S4 heterojunction: Efficiency, mechanism and toxicity evaluation”
Journal of Environmental Chemical Engineering, 2023. 11, 111522.
(8) Hai-Wei Luo, Jian-Ming Jiang, Xun Wang, Minjie Li, Jin-Jian Ding, Wen-Jun Hong*, Liang-Hong Guo*
“Contaminant occurrence, water quality criteria and tiered ecological risk assessment in water: A case study of antifouling biocides in the Qiantang River and its estuary, Eastern China”
Marine Pollution Bulletin, 2023, 194, 115311.
(9) Lu Chen, Yue Xie, Minjie Li, Monika Mortimer, Fangfang Li*, Liang-Hong Guo*
“Toxicological mechanisms of emerging per-/poly-fluoroalkyl substances: Focusing on transcriptional activity and gene expression disruption”
Toxicology, 2023, 494, 153566.
(10) Wen‑Jun Hong, Xun Wang, Jin‑Jian Ding, Jian‑Ming Jiang, Min‑Jie Li, Shaoyang Ji, Nan Sang, Liang‑Hong Guo*
“Seasonal variation, source apportionment, and cancer risk assessment of PM2.5‑bound phthalates: a case study in Taiyuan, China”
Air Quality, Atmosphere & Health, 2023. (https://doi.org/10.1007/s11869-023-01454-6)
(11) Yue Xie, Qi Zhang, Lu Chena, Fangfang Li, Minjie Li*, Liang-Hong Guo*
“Emerging organophosphate ester resorcinol bis(diphenyl phosphate) exerts estrogenic effects via estrogen receptor pathways”
Toxicology, 2023, 499, 153649.
(12) Zhi Li, Tingyu Lu, Minjie Li, Monika Mortimer*, Liang-Hong Guo*
“Direct and gut microbiota-mediated toxicities of environmental antibiotics to fish and aquatic invertebrates”
Chemosphere, 2023, 329:138692.
(13) Tingyu Lu, Monika Mortimer, Fangfang Li, Zhi Li, Lu Chen, Minjie Li,* Liang-Hong Guo*
“Putative adverse outcome pathways of the male reproductive toxicity derived from toxicological studies of perfluoroalkyl acids”
Science of the Total Environment, 2023, 873:162439.
(14) Minjie Li, Liang-Hong Guo*
“Chemo/biosensors towards effect-directed analysis: An overview of current status and future development”
TrAC Trends in Analytical Chemistry, 2023, 158, 116824.
(15) Yirong Zhang, Wenqian Huang, Minjie Li, Fangfang Li, Lingxiangyu Li, Monika Mortimer*, Liang-Hong Guo*
“Food-related engineered nanoparticles and food grade TiO2 impact the metabolism of a human commensal bacterial strain in physiologically relevant conditions”
Environ. Sci.: Nano, 2023, 10, 251.
(16) Lei, Yuyang; Li, Fangfang; Mortimer, Monika; Li, Zhi; Peng, Bi-Xia; Li, Minjie*; Guo, Liang-Hong*; Zhuang, Guoqiang
“Antibiotics disrupt lipid metabolism in zebrafish (Danio rerio) larvae and 3T3-L1 preadipocytes”
Science of the Total Environment, 2023, 858, 159755.
(17) Luo, Hai-Wei; Lin, Min; Bai, Xin-Xin; Xu, Bin; Li, Minjie; Ding, Jin-Jian; Hong, Wen-Jun*; Guo, Liang-Hong*
“Water quality criteria derivation and tiered ecological risk evaluation of antifouling biocides in marine environment”
Marine Pollution Bulletin, 2023, 187, 114500.
(18) 沈琳玉，沈丹红，陈康，李敏杰，丁锦建，张碧红*，郭良宏*
“高效降解环境新污染物四环素的复合光催化剂：从材料设计到降解机制研究”
《环境化学》，2023, 42, 859-2875.
(19) 沈丹红，姚建国，林敏，沈琳玉，陈康，李敏杰，丁锦建*，郭良宏*
“典型全氟烷基酸的光/电催化降解：性能提升策略与反应机制研究”
《环境化学》，2023, 42, 2714-2729.
(20) Zhang, Bihong; Li, Fangfang; Shen, Linyu; Chen, Lu; Xia, Zhiqiang; Ding, Jinjian; Li, Minjie*; Guo, Liang-Hong*
“A cathodic photoelectrochemical immunoassay with dual signal amplification for the ultrasensitive detection of DNA damage biomarkers”
Biosensors & Bioelectronics, 2022, 224, 115052.
(21) Muhammad Abdullahi, Xiaojing Li,* Mohamed Abou-Elwafa Abdallah, William Stubbings, Norman Yan, Marianne Barnard, Liang-Hong Guo, John K. Colbourne, Luisa Orsini
“Daphnia as a Sentinel Species for Environmental Health Protection: A Perspective on Biomonitoring and Bioremediation of Chemical Pollution”
Environmental Science & Technology, 2022, 56, 14237-14248.
(22) Wenqian Huang, Yirong Zhang, Zhi Li, Minjie Li, Fangfang Li, Monika Mortimer*, Liang-Hong Guo*
“Silver and Hyaluronic Acid-Coated Gold Nanoparticles Modulate the Metabolism of a Model Human Gut Bacterium Lactobacillus casei”
Nanomaterials, 2022, 12, 3377.
(23) Peng, Bi-Xia; Li, Fangfang; Mortimer, Monika; Xiao, Xiang; Ni, Ya; Lei, Yuyang; Li, Minjie*; Guo, Liang-Hong*
“Perfluorooctanoic acid alternatives hexafluoropropylene oxides exert male reproductive toxicity by disrupting blood-testis barrier”
Science of the Total Environment, 2022, 846, 157313.
(24) Chen, Kang; Xu, Bin; Shen, Linyu; Shen, Danhong; Li, Minjie*; Guo, Liang-Hong*
“Functions and performance of ionic liquids in enhancing electrocatalytic hydrogen evolution reactions: a comprehensive review”
RSC Advances, 2022, 12, 19452-19469.
(25) Qin, Weiping; Ren, Xiaomin; Zhao, Lixia; Guo, Lianghong*
“Exposure to perfluorooctane sulfonate reduced cell viability and insulin release capacity of beta cells”
Journal of Environmental Sciences, 2022, 115, 162-172.
(26) 蔡东明，欧阳洁，丁锦建，林敏，章维维，李敏杰*，郭良宏*
“抗生素消毒副产物的分析检测及毒性效应研究进展”
《分析化学》，2022，3，327 ~340。
(27) 罗海威，林敏，白欣欣，徐彬，李敏杰，丁锦建，洪文俊*，郭良宏*
“船舶防污杀生剂的水生生物毒性和近海海域分布特征研究进展”
《环境化学》，2022，11，3493-3513.
(28) Zhu, Jianqiao; Zhao, Lixia; Guo, Lianghong*
“Dechloranes exhibit binding potency and activity to thyroid hormone receptors”
Journal of Environmental Sciences, 2022, 112, 16-24.
(29) Li, Chuan-Hai; Zhang, Dong-Hui; Jiang, Li-Dan; Qi, Yuan; Guo, Liang-Hong*
“Binding and activity of bisphenol analogues to human peroxisome proliferator-activated receptor beta/delta”
Ecotoxicology and Environmental Safety, 2021, 226, 112849.
(30) Liu, Chang; Qie, Yu; Zhao, Lixia; Li, Minjie; Guo, Liang-Hong*
“A High-Throughput Platform for the Rapid Quantification of Phosphorylated Histone H2AX in Cell Lysates Based on Microplate Electrochemiluminescence Immunosensor Array”
ACS Sensors, 2021, 6, 3724-3732.
(31) 雷雨洋，李方方，欧阳洁，李敏杰*，郭良宏*
“浙江地区抗生素残留的环境分布特征及来源分析”
《化学进展》，2021，33，1414-1425
(32) Liu, Chang; Qie, Yu; Qin, Weiping; Zhao, Keda; Zhu, Jianqiao; Zhao, Lixia; Li, Minjie; Guo, Liang-Hong*
“Emerging immunoassay technologies for the rapid detection of exosomes”
Sensors & Actuators B-Chemical, 2021, 345, 130336.
(33) Wei, Fang; Mortimer, Monika; Cheng, Hefa; Sang, Nan*; Guo, Liang-Hong*
“Parabens as chemicals of emerging concern in the environment and humans: A review”
Science of the Total Environment, 2021, 778, 146150.
(34) Qie, Yu; Qin, Weiping; Zhao, Keda; Liu, Chang; Zhao, Lixia; Guo, Liang-Hong*
“Environmental Estrogens and Their Biological Effects through GPER Mediated Signal Pathways”
Environmental Pollution, 2021, 278, 116826.
(35) Zhao, Keda; Li, Minjie; Zhao, Lixia; Sang, Nan; Guo, Liang-Hong*
“The identification of the major contributors in atmospheric particulate matter to oxidative stress using surrogate particles”
Environmental Science: Nano, 2021, 8, 527-542.
(36) 彭碧霞，洪文俊，李方方，李敏杰*，郭良宏*
“浙江杭嘉湖地区水环境中全氟烷基化合物的污染特征及健康风险评估”
《环境化学》, 2021, 40, 3001-3014.
(37) 陈世存，陶芳*，丁锦建，洪文俊，郭良宏*
“新型有机磷阻燃剂环境污染物的研究进展”
《环境化学》, 2021, 40, 949-963.
(38) Huang, Wenqian; Tao, Fang; Li, Fangfang; Mortimer, Monika*; Guo, Liang-Hong*
“Antibacterial nanomaterials for environmental and consumer product applications”
NanoImpact, 2020, 20, 100268.
(39) Zheng, Xiyue; Ren, Xiao-Min; Zhao, Lixia; Guo, Liang-Hong*
“Binding and activation of estrogen related receptor gamma as possible molecular initiating events of hydroxylated benzophenones endocrine disruption toxicity”
Environmental Pollution, 2020, 263, 114656.
(40) Yirong Zhang, Monika Mortimer*, Liang-Hong Guo*
“Interplay between Engineered Nanomaterials and Microbiota”
Environ. Sci.: Nano, 2020, 7, 2454–2485.
(41) Chuan-Hai Li, Ya-Li Shi, Minjie Li, Liang-Hong Guo*, Ya-Qi Cai
Receptor-Bound Perfluoroalkyl Carboxylic Acids Dictate Their Activity on Human and Mouse Peroxisome Proliferator-Activated Receptor γ
Environ. Sci. Technol. 2020, 54, 9529−9536.
(42) Fadare, Oluniyi O; Wan, Bin*; Liu, Keyang; Yang, Yu; Zhao, Lixia; Guo, Liang-Hong*
“Eco-Corona vs Protein Corona: Effects of Humic Substances on Corona Formation and Nanoplastic Particle Toxicity in Daphnia magna”
Environmental Science & Technology, 2020, 54, 8001-8009.
(43) Yan Xin, Bin Wan, Bolan Yu, Yong Fan, De Chen, Liang-Hong Guo*
“Chlorinated Polyfluoroalkylether Sulfonic Acids Exhibit Stronger Estrogenic Effects than Perfluorooctane Sulfonate by Activating Nuclear Estrogen Receptor Pathways”
Environ. Sci. Technol. 2020, 54, 3455−3464.
(44) Wei-Ping Qin, Lin-Ying Cao, Chuan-Hai Li, Liang-Hong Guo*, John Colbourne, Xiao-Min Ren*
“Perfluoroalkyl Substances Stimulate Insulin Secretion by Islet β Cells via G Protein-Coupled Receptor 40”
Environ. Sci. Technol. 2020, 54, 3428−3436.
