教育经历：

2017.9-2021.7 中国科学院动物研究所 博士学位 导师：戴家银研究员

2014.9-2017.6 上海海洋大学 硕士学位 导师：陈松林院士

2009.9-2013.6 烟台大学 学士学位

工作经历：

2023.9-今 国科大杭州高等研究院 环境学院 助理研究员

2021.7-2023.9 国科大杭州高等研究院，环境学院，博士后 合作导师：胡立刚教授

承担科研项目：

1. 国家自然科学基金青年基金项目, 22206036：基于胆汁排出途径的大鼠肝脏中铅代谢分子机制研究 （2023.1-2025.12） 30万 主持

2. 中国博士后科学基金面上项目, 2021M703404, 肝肠循环在铅的代谢中的作用机制研究, 2022-01 至今, 8万元, 在研, 主持

3. 国家自然科学基金重大项目, 22193052, 生命过程中外源污染物的暴露途径和归趋, 2022-01-01 至 2026-12-31, 431万元, 在研, 参与

获奖及荣誉：

1. 2019 博士研究生国家奖学金 国科大三好学生标兵

2. 2020 地奥奖学金

3. 2021 中科院院长优秀奖

代表论著：

1. Guo, H.; Tang, Y.; Li, Y.; Tian, H.; Zhang, T.; Li, Y.; Liu, L.; He, B.; Hu, L.; Jiang, G. Endocytosis-Mediated Transport of Pb in Rat Blood Cells. Environ. Sci. Technol. 2023. 57(23), 8514–8523

2. Guo, H.; Chen, J.; Zhang, H.; Yao, J.; Sheng, N.; Li, Q.; Guo, Y.; Wu, C.; Xie, W.; Dai, J., Exposure to GenX and Its Novel Analogs Disrupts Hepatic Bile Acid Metabolism in Male Mice. Environ. Sci. Technol. 2022, 56 (10), 6133-6143.

3. Guo, H.; Wang, J.; Yao, J.; Sun, S.; Sheng, N.; Zhang, X.; Guo, X.; Guo, Y.; Sun, Y.; Dai, J., Comparative Hepatotoxicity of Novel PFOA Alternatives (Perfluoropolyether Carboxylic Acids) on Male Mice. Environ. Sci. Technol. 2019, 53, (7), 3929-3937.

4. Guo, H.; Zhang, H.; Sheng, N.; Wang, J.; Chen, J.; Dai, J., Perfluorooctanoic acid (PFOA) exposure induces splenic atrophy via overactivation of macrophages in male mice. J. Hazard. Mater. 2021, 407.

5. Guo, H.; Sheng, N.; Guo, Y.; Wu, C.; Xie, W.; Dai, J., Exposure to GenX and its novel analogs disrupts fatty acid metabolism in male mice. Environ. Pollut. 2021, 291.

6. Guo, H.; Wei, M.; Liu, Y.; Zhu, Y.; Xu, W.; Meng, L.; Wang, N.; Shao, C.; Lu, S.; Gao, F.; Cui, Z.; Wei, Z.; Zhao, F.; Chen, S., Molecular cloning and expression analysis of the aqp1aa gene in half-smooth tongue sole (Cynoglossus semilaevis). Plos One 2017, 12, (4).

7. Gui, W.; Guo, H.; Wang, J.; Wang, C.; Guo, Y.; Zhang, K.; Dai, J.; Zhao, Y. * Nafion by-product 2 disturbs lipid homeostasis in zebrafish embryo. Environ. Pollut. 2023, 322.

8. Gui, W.; Guo, H.; Chen, X.; Wang, J.; Guo, Y.; Zhang, H.; Zhou, X.; Zhao, Y.; Dai, J.* Emerging polyfluorinated compound Nafion by-product 2 disturbs intestinal homeostasis in zebrafish (Danio rerio). Ecotoxicol. Environ. Saf. 2023, 249, 114368-114368.

9. Gui, W.; Guo, H.; Wang, C.; Li, M.; Jin, Y.; Zhang, K.; Dai, J.; Zhao, Y. Comparative developmental toxicities of zebrafish towards structurally diverse per- and polyfluoroalkyl substances. Sci. Total Environ. 2023, 902, 166569.

10. Sun, S.; Guo, H.; Wang, J.; Dai, J.* Hepatotoxicity of perfluorooctanoic acid and two emerging alternatives based on a 3D spheroid model. Environ. Pollut. 2019, 246, 955-962.

11. Shi, G.; Guo, H.; Sheng, N.; Cui, Q.; Pan, Y.; Wang, J.; Guo, Y.; Dai, J.* Two-generational reproductive toxicity assessment of 6:2 chlorinated polyfluorinated ether sulfonate (F-53B, a novel alternative to perfluorooctane sulfonate) in zebrafish. Environ. Pollut. 2018, 243, 1517-1527.